You Searched For: PD+98059

Catalog Number: (75791-904)

Supplier: Prosci

Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Catalog Number: (75791-760)

Supplier: Prosci

Description: CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

Catalog Number: (103294-696)

Supplier: Novus Biologicals

Description: The PD-1 Antibody (913425) [DyLight 488] from Novus Biologicals is a mouse monoclonal antibody to PD-1. This antibody reacts with human. The PD-1 Antibody (913425) [DyLight 488] has been validated for the following applications: Flow Cytometry.

Supplier: Thermo Scientific Chemicals

Description: Dipotassium hexabromopalladate ≥99.999% (metals basis) Pd ≥ 15.5%, Premion®

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Supplier: MilliporeSigma

Description: Bis(Triphenylphosphine)Palladium(Ii) Chloride (15.2% Pd) for Synthesis Cas Number:13965-03-2 500Mg

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Catalog Number: (10092-020)

Supplier: Proteintech

Description: Anti-PD-ECGF Rabbit Polyclonal Antibody

Supplier: Thermo Scientific Chemicals

Description: Allylpalladium(II) chloride dimer (≥ 56,0% Pd)

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Supplier: Thermo Scientific Chemicals

Description: Uses: Hydrogenolysis of benzyl-nitrogen bonds
Sold on a dry weight basis. Unit weight excludes water weight

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Supplier: AFG Bioscience

Description: Anti-Ribosome-inactivating protein PD-L1/PD-L2 Rabbit Recombinant Antibody (FITC (Fluorescein Isothiocyanate))

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Supplier: Peprotech

Description: Programmed cell death protein 1 (PD-1), or CD279, is a type I inhibitory transmembrane receptor of the CD28 receptor family that, along with its B7 family ligands, programmed death ligand 1 (PD-L1) and programmed death ligand 2 (PD-L2), belongs to the immunoglobulin superfamily. While other CD28 family members are expressed predominantly in T cells, PD-1 is widely expressed and found in multiple lymphocytes including T cells, B cells, myeloid, and NKT cells upon activation. PD-1 is a negative regulator of immune response, and is referred to as an inhibitory immune checkpoint molecule. Ligation with PD-L1 or PD-L2 results in inhibited activation, proliferation, and cytokine secretion (e.g. IFN-gamma, IL-10) in T cells, ultimately dampening immune response. Despite the strong homology between PD-L1 and PD-L2, each ligand appears to display distinct lymphokine expression patterns and potency. Blockage of PD-1 ligation by monoclonal antibodies has been proven to be an effective anti-tumor treatment by allowing the immune response to remain active and attack the tumorigenic cells that otherwise would have escaped detection. PD-1 and its ligands have been implicated in numerous autoimmune diseases, inflammatory liver disease and cancers. The naturally occurring human PD-1 monomer consists of a 150 amino acid extracellular domain, a 21 amino acid transmembrane domain, and a 97 amino acid cytoplasmic domain. PeproTech's CHO cell-derived Recombinant Human PD-1 Fc is a glycosylated, disulfide-linked homodimer of 501 amino acid residues whose monomer consists of the 268-amino-acid length mature PD-1 sequence fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of monomeric CHO cell-derived Recombinant Human PD-1 Fc is 55.3 kDa, however, due to glycosylation, it migrates at an apparent molecular weight of approximately 180-200 kDa by SDS-PAGE analysis under non-reducing conditions.

Catalog Number: (76236-264)

Supplier: Rockland Immunochemical

Description: Human PD-L1 - B7-H1 AccuSignal ELISA Kit

Supplier: Diagnostic Biosystems

Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

Catalog Number: (CA76634-554)

Supplier: Diagnostic Biosystems

Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

Catalog Number: (76236-266)

Supplier: Rockland Immunochemical

Description: Mouse PD-L1 - B7-H1 AccuSignal ELISA Kit

Supplier: ANTIBODIES.COM LLC

Description: Recombinant Human PD-L1 (from HEK293 cells)

Catalog Number: (CA8.14573.8500)

Supplier: MilliporeSigma

Description: Palladium(II) nitrate dihydrate (40% Pd), Cas: 32916-07-7, Chemical Formula: Pd(NO3)2.2 H2O, for synthesis, Size: 500 mg

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