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Catalog Number: (10496-316)
Supplier: Bioss
Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.


Catalog Number: (CA101444-748)
Supplier: New England Biolabs (NEB)
Description: Taq 5X Master Mix is an optimized ready-to-use solution containing Taq DNA Polymerase, dNTPs, MgCl2, KCl and stabilizers


Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00149674 Soluble in water, methanol, ethanol
Supplier: Ward's Science
Description: Learn the history of the discovery of DNA and DNA structure, the nature of genetic inheritance, and the tole of DNA and proteins in genetic expression.

Catalog Number: (CA611-905-002)
Supplier: Rockland Immunochemical
Description: Secondary Chicken Anti-IgG (H&L) Reacts with Rabbit (Lapine)


Catalog Number: (76534-356)
Supplier: Antyila Scientific
Description: Built-in vent releases built-up pressure, prevents leaking.


Catalog Number: (470121-766)
Supplier: Edvotek
Description: Applying what was learned in Lab 1, students study the movement of water within the plant, then prepare and study sections of fresh plant stem tissueRequired, but not included: microscope(s), slides and coverslips, ring stands and clamps, 100 W light source, fan, scale or balance, spray bottle, 10 ml pipets, spatulas, razor or scalpel blades, potting soil, petroleum jelly, 50% ethanol, mounting media, and large plastic bags. For 10 student groups.


Catalog Number: (SXS-1890)
Supplier: SPEX CERTIPREP LLC
Description: Single-Component organic standards.


Catalog Number: (TCH1043-1G)
Supplier: TCI America
Description: CAS Number: 24342-68-5
MDL Number: MFCD06797107
Molecular Formula: C19H32O7
Molecular Weight: 372.46
Purity/Analysis Method: >93.0% (GC)
Form: Clear Liquid

Catalog Number: (76108-370)
Supplier: Bioss
Description: The FAH family contains two highly homologous 314 amino acid proteins, designated FAHD2A (fumarylacetoacetate hydrolase domain-containing protein 2A) and FAHD2B (fumarylacetoacetate hydrolase domain-containing protein 2A). FAHD2A and B utilize calcium and magnesium as cofactors, and may possess hydrolase activity. The genes encoding FAHD2A/B map to human chromosome 2, the second largest human chromosome, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome, is also associated with mutations to chromosome 2.


Supplier: Biotium
Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium
Description: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Catalog Number: (TCT1997-5G)
Supplier: TCI America
Description: CAS Number: 86259-87-2
MDL Number: MFCD06797175
Molecular Formula: C15H24O5
Molecular Weight: 284.35
Purity/Analysis Method: >95.0% (GC)
Form: Clear Liquid
Color: Very Pale Yellow
Specific Gravity (20/20): 1.10

Supplier: Thermo Scientific Chemicals
Description: 2-Iodoethanol 99% stabilized
Catalog Number: (76110-648)
Supplier: Bioss
Description: FIGNL1 is a 674 amino acid protein belonging to the AAA ATPase family. FIGNL1 exists as a hexamer that undergoes alternative splicing to produce two isoforms. FIGNL1 utilizes magnesium as a cofactor and is phosphorylated upon DNA damage, probably by ATM or ATR. FIGNL1 is suggested to regulate osteoblast proliferation and differentiation. FIGNL1 is encoded by a gene located on human chromosome 7, which consists about 158 million bases, encodes over 1000 genes and makes up about 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia.


Catalog Number: (89417-830)
Supplier: Prosci
Description: ATP2C2 Antibody: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.


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