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Product Image-89147-008

MMP-3 inhibitor ≥95% (by HPLC)

Catalog Number: (89147-008)
Supplier: Enzo Life Sciences
Description: Inhibitor of matrix metalloproteinase 3 (MMP-3) (IC50=5µM).
Image Unavailable-N-1405.0005BA

MMP inhibitor I

Supplier: Bachem Americas
Description: Sequence: 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH
Synonym(s): MMP Inhibitor 1

Image Unavailable-89158-008

CL-82198 (MMP-13 inhibitor) ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: A novel and selective inhibitor of MMP-13 (89% at 33 µM). Acts via binding to the S1' pocket of MMP-13 without metal chelation.

Image Unavailable-75791-486

Human Recombinant TIMP-4 (from Cells)

Catalog Number: (75791-486)
Supplier: Prosci
Description: Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Image Unavailable-89161-606

NNGH ≥99% (by TLC)

Supplier: Enzo Life Sciences
Description: MMP inhibitor

Image Unavailable-89158-076

SB-3CT ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: Competitive, mechanism-based inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9). It possesses Ki values in the nanomolar range against the gelatinases (14nM for MMP-2; 600nM for MMP-9), but in the micromolar range against other metalloproteinases (206µM for MMP-1, 15µM for MMP-3, 96µM for MMP-7, and 4µM for ADAM17/TACE). This inhibitor has also been used in vitro, in vivo, and in tissue culture. In vivo, it is metabolized to an even more potent gelatinase inhibitor.

Product Image-89156-416

MMP Inhibitor Profiling Kit, Colorimetric, Enzo Life Sciences

Catalog Number: (89156-416)
Supplier: Enzo Life Sciences
Description: A QUANTIZYME® Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a chromogenic substrate1,2 detected at 412nm. Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.
Image Unavailable-75789-506

Human Recombinant TIMP2 (from Cells)

Catalog Number: (75789-506)
Supplier: Prosci
Description: Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Product Image-89156-418

MMP Inhibitor Profiling Kit, Fluorometric, Enzo Life Sciences

Catalog Number: (89156-418)
Supplier: Enzo Life Sciences
Description: A QUANTIZYME® Assay System Complete assay system designed to examine the specificity of inhibitors against a panel of ten matrix metalloproteinase enzymes. The assays are performed in a convenient 96-well microplate format using a sensitive fluorogenic substrate . Included are active MMP enzymes, assay buffer, a prototypic control inhibitor (NNGH3), and a detailed instruction booklet.
Image Unavailable-103010-412

SensoLyte® Generic MMP Assay Kit (Colorimetric), AnaSpec Inc.

Catalog Number: (103010-412)
Supplier: Anaspec Inc
Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components
Product Image-89158-002

GM-6001

Supplier: Enzo Life Sciences
Description: MMP inhibitor

Image Unavailable-89161-702

PF-356231 ≥98% (by TLC)

Catalog Number: (89161-702)
Supplier: Enzo Life Sciences
Description: Specific non-chelating small-molecule inhibitor of MMP-12 (IC50 = 14 nM). At higher concentrations it inhibits other MMPs, but spares MMP-1, making it a valuable tool for investigation of MMP activity and function.
Image Unavailable-103001-348

Human Recombinant MMP-12 (from E. coli)

Supplier: Anaspec Inc
Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is involved in smoke-induced emphysema, tumor and other diseases. MMP-12 is secreted as a 54-kDa zymogen and becomes the mature 45-kDa active form after proteolytic cleavage. MMP-12 has a broad range of substrates, including α-1 proteinase inhibitor, α-2 antiplasmin, plasminogen activator inhibitor-2, collagen IV, laminin, fibronectin, elastin, but not interstitial collagens.

The sequence (Accession # NP_002417) corresponding to the catalytic domain (aa 106-267) of Human MMP-12 was expressed in E. coli. The recombinant human MMP-12 was purified from bacterial lysate and refolded using proprietary technique. The molecular weight of the recombinant Human MMP-12 Catalytic Domain is 18 kDa.

Product Image-89156-462

Matrix Metalloproteinase-7 (MMP-7) Colorimetric Drug Discovery Kit, Enzo Life Sciences

Catalog Number: (89156-462)
Supplier: Enzo Life Sciences
Description: A QuantiZymeTM Assay SystemThe MMP-7 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-7 (MMP-7, matrilysin) using a thiopeptide as a chromogenic substrate.
Product Image-89161-004

Cathepsin D&E Fluorogenic Substrate

Catalog Number: (89161-004)
Supplier: Enzo Life Sciences
Description: Quenched fluorogenic substrate for cathepsin D (kcat/Km=1.09 x 10 M-1s-1) and cathepsin E (kcat/Km=1.56 x 10 M-1s-1). Mca fluorescence is quenched by the Dnp group until cleavage separates them. Activity of the two enzymes on this substrate can be distinguished by the use of Ascaris pepsin inhibitor, which inhibits cathepsin E, but not cathepsin D. This substrate is also cleaved by MMP-2, MMP-3, MMP-9, but not MMP-1 nor MMP-13. This substrate is useful for inhibitor screening and kinetic analysis. Ex.: 320-340 nm, Em.: 393-420 nm. Mca-Pro-Leu-OH (BML-P127) can be used to calibrate for Mca fluorescence.
Image Unavailable-75789-500

Human Recombinant TIMP1 (from Cells)

Catalog Number: (75789-500)
Supplier: Prosci
Description: Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16. TIMP-1 does not act on MMP-14.
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