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Supplier: Abcam
Description: Rabbit monoclonal [EPR6283(2)] to HGFA Inhibitor 2 - BSA and Azide free.

New Product

Catalog Number: (10425-638)
Supplier: Bioss
Description: Matrix Metalloproteinase 28, also known as epilysin, was first cloned from human skin keratinocytes and described to reflect its role in the remodeling of the epidermis. It was found in testis, as well as heart, brain, placenta, lung, prostate, intestine, and colon. MMP28 was later cloned from human lung and found in lung, kidney, brain, skeletal muscle, and several tumor cell lines. At least three MMP28 transcripts of 2.6, 2.0, and 1.2 kb have been reported possibly representing alternatively spliced forms of MMP28. There are two human sequences (isoform1 and isoform 2) which encode proteins of 520 and 393 amino acids with predicted masses of 58.9 and 44.5 kDa respectively. The mouse sequence contains two inserts of 41 and 39 amino acids respectively, relative to the human sequence. Mouse epilysin has a predicted molecular mass of approx. 70 kDa. Mouse and human epilysin are highly conserved and share 97% identical residues. Epilysin (MMP-28) contains the key domains of the other MMPs: a signal peptide, conserved cysteine-containing prodomain (with a furin cleavage site), conserved histidine-containing catalytic domain, hinge domain, and hemopexin domain. MMP28 has a furin cleavage site, similar to MMP11, and is cleaved by the prohormone convertase family of enzymes. Sequence identity between MMP28 and the other MMPs is low overall. MMP28 is most closely related to MMP19 (39% sequence identity). Recombinant MMP28 degrades casein.


Catalog Number: (76715-512)
Supplier: AFG Bioscience
Description: Human Inhibitor of growth Protein 4(ING4) ELISA Kit


Catalog Number: (76699-028)
Supplier: AFG Bioscience
Description: Human Inhibitor of growth Protein 1(ING1) ELISA Kit


Catalog Number: (10207-782)
Supplier: Boster Biological Technology
Description: Sandwich ELISA kit of Quantitative Detection for Human MMP-2


Catalog Number: (10205-834)
Supplier: Boster Biological Technology
Description: Sandwich ELISA kit of Quantitative Detection for Rat MMP-2


Catalog Number: (10207-790)
Supplier: Boster Biological Technology
Description: Sandwich ELISA kit of Quantitative Detection for Human MMP-7


Catalog Number: (89277-398)
Supplier: Genetex
Description: Rabbit Antibody to MMP - 11 ( C - Terminal )


Catalog Number: (89155-994)
Supplier: Enzo Life Sciences
Description: Synthetic peptide inhibitors that irreversibly inhibit the activity of each of the caspase-family proteases. YVAD is the recognition sequence for caspase-1, VDVAD is the recognition sequence for caspase-2, DEVD is the recognition sequence for caspase-3, VEID is the recognition sequence for caspase-6, IETD is the recognition sequence for caspase-8, LEHD is the recognition sequence for caspase-9, and VAD is the recognition sequence for a caspase(s) that functions upstream of most other caspases.


Catalog Number: (10403-746)
Supplier: Bioss
Description: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.


Catalog Number: (ABCA_AB313834-100U)
Supplier: Abcam
Description: Rabbit monoclonal [HL1196] to C1 inhibitor - BSA and Azide free.

New Product


Catalog Number: (89160-342)
Supplier: Enzo Life Sciences


Catalog Number: (75878-184)
Supplier: BIOASSAY SYSTEMS
Description: A general inhibitor for protein phosphotyrosyl phosphatases.


Supplier: AFG Bioscience
Description: Anti-Major pepsin inhibitor 3 Rabbit Recombinant Polyclonal Antibody

New Product

Catalog Number: (76101-104)
Supplier: Bioss
Description: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.


Supplier: Thermo Scientific Chemicals
Description: Powder
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