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Image Unavailable-76100-034

Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)

Catalog Number: (76100-034)
Supplier: Bioss
Description: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Image Unavailable-CAAA11252-14

Neodymium(III) chloride hydrate ≥99.99% (REO, rare earth oxide basis), REacton®

Supplier: Thermo Scientific Chemicals
Description: Neodymium(III) chloride hydrate is used for production of neodymium metal. It also finds application in lasers and fiber amplifiers. It serves as dopants for silica based as well as plastic fibers. It plays an important role of additives in organic light emitting diodes resulting in improved LED emission spectrum. In addition, it is used in catalysis of polymerization of various dienes. It is used to modify titanium dioxide for use as a photocatalyst. Its coating on aluminum and its alloy protect them from corrosion. It is also extensively used as fluorescent labels for organic molecules.

Certificates

Image Unavailable-700013-134

Dextran, M.W. ~ 250,000, powder

Catalog Number: (700013-134)
Supplier: Spectrum Chemicals
Description: Dextran, 250,000, Powder is a complex branched glucan that is synthesized by certain lactic acid bacteria from sucrose. Commonly used in microsurgery to decrease the risk of vascular thrombosis, these agents are also used as effective osmotic agents and can treat hypovolemia. In the laboratory, Dextran is used to apply osmotic pressure to biological molecules and can, when applied with a fluorescent molecule, be used to create concentration gradients of diffusible molecules.

Certificates Small Business Enterprise


Product Image-89166-434

MonitorTM 2000 Germicidal Cabinet, Sellstrom Mfg Co

Catalog Number: (89166-434)
Supplier: Sellstrom
Description: Monitor 2000 germicidal cabinet sanitize goggles/safety glasses for next use and specially designed for educational and medical industry applications. It sanitizes eyewear surfaces from germs, bacteria, mold, fungus contaminants and features tamper-resistant latches with two keys provided. Also it kills 99.4% of germs during the timer-controlled cycle - third-party tested.

Small Business Enterprise


Image Unavailable-95035-988

Sodium thiosulfate pentahydrate ≥99%, crystals USP, Ph. Eur., BP, JP

Supplier: Spectrum Chemicals
Description: Sodium Thiosulfate, Pentahydrate, Crystal, USP, EP, BP, JP is used as a bleach neutralizer.

Certificates Small Business Enterprise

Image Unavailable-75811-938

L(+)-Potassium sodium tartrate tetrahydrate ≥99.0%, powder FCC

Catalog Number: (75811-938)
Supplier: Spectrum Chemicals
Description: Sodium Potassium Tartrate, Tetrahydrate, Powder, FCC is used as a sequestrant and stabilizer. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Image Unavailable-76100-036

Anti-hHR23b Rabbit Polyclonal Antibody (ALEXA FLUOR® 750)

Catalog Number: (76100-036)
Supplier: Bioss
Description: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Product Image-470165-022

ENG Box Electricity

Catalog Number: (470165-022)
Supplier: KIDDER MFG. CO. LTD
Description: This kit on its own allows a student to experiment with series and parallel circuits, switches and solar power and potentially build their own board game that utilizes the led’s and buzzers.
Image Unavailable-77663-974

FO-6000 Replacement Bulb

Catalog Number: (77663-974)
Supplier: WORLD PRECISION INSTRUMENTS LLC
Description: Spectrum lamp, Replacement lamp for FO-6000

New Product


Product Image-89022-940

ESD Shallow Textured Bottom Tray, MFG Tray

Catalog Number: (89022-940)
Supplier: Molded Fiber Glass Tray
Description: Used in the assembly of circuit boards, computers, medical device, and other types of electronic or static sensitive assembly
Product Image-470358-032

Kidder Farm in a Box Grow Kit

Catalog Number: (470358-032)
Supplier: KIDDER MFG. CO. LTD
Description: <p>Students build their own plant center!</p>

New Product


Image Unavailable-75810-952

Copper(II) sulfate pentahydrate ≥98.5%, granular USP

Supplier: Spectrum Chemicals
Description: Cupric Sulfate, Pentahydrate, Granular, USP is a mineral supplement. 

Product Image-470024-814

Loading Dye

Catalog Number: (470024-814)
Supplier: Ward's Science
Description: Solution used for tracking DNA during agarose electrophoresis; prepared with ultra-pure water and reagent-grade chemicals. 10X concentration.

SDS


Image Unavailable-10841-962

2-Methoxy-1-methylethyl acetate (PGMEA) ≥99%

Catalog Number: (10841-962)
Supplier: Spectrum Chemicals
Description: Propylene Glycol Methyl Ether Acetate is a glycol type solvent used in inks, coatings, and cleaners.
Image Unavailable-75810-820

L(+)-Cysteine hydrochloride monohydrate ≥98.0% FCC

Catalog Number: (75810-820)
Supplier: Spectrum Chemicals
Description: L-Cysteine Monohydrochloride, Monohydrate, FCC - The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Image Unavailable-75811-942

L(+)-Potassium sodium tartrate tetrahydrate ≥99.0%, granular FCC

Supplier: Spectrum Chemicals
Description: Sodium Potassium Tartrate, Tetrahydrate, Granular, FCC is used as a sequestrant and stabilizer. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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