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Catalog Number: (10429-068)
Supplier: Bioss
Description: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.


Catalog Number: (89417-470)
Supplier: Prosci
Description: SIRT3 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence, lifespan extension and several age-related diseases. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death.


Catalog Number: (10221-846)
Supplier: YSI
Description: Rugged and reliable, the YSI Pro10 provides everything you need in a handheld instrument for the measurement of either pH or ORP along with temperature.


Catalog Number: (CAPIPA5-13605)
Supplier: Thermo Scientific
Description: HPX is a plasma glycoprotein that binds heme with high affinity. The protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress.


Supplier: VWR
Description: These buffer solutions are for calibrating pH meters
Supplier: Thermo Fisher Scientific
Description: Get premium performance and ultimate flexibility with the Orion™ Versa Star Pro™ Benchtop Multiparameter Meter with pH/ISE Module for pH, ion concentration, and temperature.

Catalog Number: (10342-364)
Supplier: Bioss
Description: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.


Catalog Number: (10342-206)
Supplier: Bioss
Description: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.


Supplier: Binder
Description: <p>The KBF series is a proven specialist for reliable ICH stability tests in the pharmaceutical industry: the KBF masters all long-term tests, accelerated tests and stress tests. It fulfills all important ICH requirements, from precision to programming and documentation. With flexible water supply options for all installation locations.</p>

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Supplier: Thermo Fisher Scientific
Description: Get premium performance and flexibility with the Orion™ Versa Star Pro™ Meter with pH and Conductivity Modules for simultaneous pH, conductivity, and temperature analysis.

Catalog Number: (MFLX07571-02)
Supplier: Avantor Fluid Handling
Description: Sample depths down to 7.9 meters (26 feet).

UL Listed ISO9001 CE Compliant CSA Certified 2 year warranty


Catalog Number: (10122-576)
Supplier: YSI
Description: The YSI TruLab® line includes the 1110 (single channel), 1310 and 1310P (single channel) and 1320 and 1320P (dual channel) instruments providing easy-to-use and calibrate instruments ideal for the laboratory.


Catalog Number: (10430-428)
Supplier: Bioss
Description: The Rho family of proteins mediates cytoskeleton organization and cell motility responses. This family contains twenty different members divided into five groups, the Rho-like, Rac-like, Cdc42-like, Rnd and RhoBTB subfamilies. Rho proteins have GTPase activity and bind GTP in their active form and GDP in their inactive form. In their active form they interact with downstream proteins. However, the Rnd subfamily of proteins containing the Rnd1, Rnd2 and RhoE(Rnd3), binds GTP but not GDP and has no GTPase activity. While Rho proteins are required for stress fibre formation in cultured fibroblasts, epithelial and endothelial cells, overexpression of Rnd3 or Rnd1 in the same cells may cause an opposite effect (i.e. decrease in stress fibre). Thus, the Rnd3 protein may act as an antagonist for the Rho proteins either by directly binding to Rho or to other downstream proteins.


Supplier: Mettler Toledo

Catalog Number: (10813-728)
Supplier: Prosci
Description: May act as a mediator of stress-activated signals.


Supplier: Mettler Toledo
Description: SevenExcellence stands for convenient, easy-to-understand operation combined with high measurement accuracy and outstanding reliability.

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