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Product Image-89408-324

Low Profile Roller, IBI Scientific

Supplier: IBI Scientific
Description: The IBI Low Profile Roller is a lightweight unit designed as a compact, space saving, non-dedicated instrument

Product Image-470110-996

General Fossil Collection

Catalog Number: (470110-996)
Supplier: SCOTT RESOURCES 2, LLC SE
Description: Educators introduce students to ancient plant and animal life with the General Fossil Collection.
Product Image-56617-339

Overpack and Salvage Drums, UN and DOT, Eagle Mfg

Supplier: Eagle Manufacturing
Description: Designed for use with hazardous materials, Packing Groups I, II, and III.

Product Image-MFLX06383-97

Union Fittings, Hose Barb, Straight, PFA

Supplier: ANDON SPECIALTIES INC.
Description: Quick and easy assembly without tools.

Image Unavailable-CAAAAA12123-0E

Calcium bis(dihydrogenorthophosphate) hydrate 97%

Supplier: Thermo Scientific Chemicals
Description: Applications: pH control reagent, stabilizer for plastics, mfg. of glass
Loses H2O at 100°, dec. at 200°

Certificates

Product Image-470014-892

Economy Buret Clamps

Supplier: C & A Scientific
Description: This zinc-plated stamped steel clamp has a plastic coated round jaw.

Image Unavailable-75789-266

Human Recombinant Fc gamma RIIa (from Cells)

Catalog Number: (75789-266)
Supplier: Prosci
Description: Receptors for the Fc region of IgG (Fc gamma R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human Fc gamma Rs are divided into three classes designated Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16), which generate multiple isoforms, are recognized. The activating­ type receptor either has or associates non­covalently with an accessory subunit that has an immunoreceptor tyrosine­based activation motif (ITAM) in its cytoplasmic domain. Fc gamma RI binds IgG with high affinity and functions during early immune responses, whereas Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human Fc gamma RII (A, B, and C) and one for mouse (Fc gamma RIIB), encoding type I transmembrane proteins with ITAM motifs (Fc gamma RII A and C) or ITIM motifs (Fc gamma RIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a), Fc gamma RII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcR gamma , CD32a (Fc gamma RII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fc gamma RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.
Product Image-94007-932

Accessories for NMC CPM100 Lebel And Sign Printing System

Supplier: ACCUFORM MANUFACTURING, INC
Description: Weeding Tool For CPM100

Product Image-470002-900

Ward's® Advanced Zoology Dissecting Set

Catalog Number: (470002-900)
Supplier: Dunrite Instruments
Description: More tools for a finer dissection.
Product Image-470039-454

Three-Oscilloscope Probe Kit

Supplier: CAL TEST ELECTRONICS SE
Description: Designed for use with general purpose oscilloscopes.

Image Unavailable-89366-728

Anti-RFP Mouse Monoclonal Antibody

Catalog Number: (89366-728)
Supplier: Genetex
Description: ince the molecular cloning of GFP cDNA and demonstration of GFP as a functional transgene, GFP has become a powerful tool with exciting applications in developmental, cell and molecular biology. RFP is the recent discovered protein that has the similar function and applications as GFP. Either GFP or RFP fluorescence is not species specific and can be expressed in bacteria, yeast, plant and mammalian cells. GFP or RFP can fuse with proteins of interest without interfering significantly with their assembly and function.
Product Image-MFLX34030-88

Adapter Fittings, Hose Barb to Female NPT Threaded, Straight

Supplier: MICROMOLD PRODUCTS, INC.
Description: No tools needed for assembly.

CE certificate

Product Image-470334-810

Bone Shears

Supplier: AFTAB AHMED SE
Description: Easily snip through bones.

Product Image-100500-256

Paraffin wax blended with synthetic polymers, Polyfin™ embedding agent for histology

Catalog Number: (100500-256)
Supplier: Electron Microscopy Sciences
Description: Polyfin is a mixture of highly refined paraffins and co-polymer alloys in a convenient wax pellet.

Minority or Woman-Owned Business Enterprise


Product Image-470151-150

Rocks, Minerals, And Gemstones of the United States, GEOSCIENCE INDUSTRIES INC SE

Catalog Number: (470151-150)
Supplier: Geoscience Industries
Description: Collection of rocks, minerals and gemstones typical of those found in the United States and North America.
Product Image-10418-050

Anti-PRKCQ Rabbit Polyclonal Antibody

Catalog Number: (10418-050)
Supplier: Bioss
Description: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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