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PolarPack® Therapeutic Gel Packs, Flexible Gel Ice Packs, Sonoco ThermoSafe

Supplier: Sonoco Thermosafe
Description: Cold and warm pack therapy used by physical therapists, hospitals, and physicians as a therapeutic compress to treat areas of pain and inflammation.

Product available on GSA Advantage®

Image Unavailable-76099-058

Anti-Complement C4 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76099-058)
Supplier: Bioss
Description: Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Product Image-CA10500-564

Transform, Nitrile Exam Gloves, Supermax Healthcare Canada

Supplier: SUPERMAX HEALTHCARE CANADA CA
Description: Optimal stretchability, just like latex.

Product Image-77591-904

FARRAR® Lab Grade Upright and Undercounter Freezers (–30 °C)

Supplier: TRANE TECHNOLOGIES HOLDCO INC.
Description: FARRAR Lab grade freezers are the ideal solution when temperature excursions, reaching/maintaining set point temperature and ice management are a challenge.

New Product

Image Unavailable-10230-980

Anti-CASP10 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10230-980)
Supplier: Bioss
Description: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.
Product Image-CA45001-088

Water, Cell Culture Grade, tested to USP specifications for injection, sterile, Corning®

Supplier: Corning
Description: Cell culture grade water is high-quality water suitable for use as a solvent in the preparation of cell culture media and laboratory reagents.

Certificates

Image Unavailable-10230-982

Anti-CASP10 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10230-982)
Supplier: Bioss
Description: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.
Image Unavailable-10230-984

Anti-CASP10 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10230-984)
Supplier: Bioss
Description: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.
Product Image-10804-964

Protector® Pass-Through Laboratory Hoods, Labconco®

Supplier: Labconco
Description: Laboratory hoods feature sashes on two sides that, when mounted in an island or peninsular configuration, provide unobstructed viewing from either side during chemistry demonstrations or observing students using the hood

UL Listed Environmentally Preferable CSA Certified Product available on GSA Advantage®

Image Unavailable-103307-138

Freeze Substitution Kit, Electron Microscopy Sciences

Supplier: Electron Microscopy Sciences
Description: For dehydration and fixation of rapidly frozen cells.

Product Image-80067-980

Straight Drying Tubes, Chemglass

Supplier: Chemglass
Description: Vertical drying tubes with a beaded top and [ST] lower inner joint.

Small Business Enterprise

Product Image-75999-324

VWR® Bead Sterilizers

Supplier: VWR International
Description: Research sterilizer for needles, forceps, tweezers, and other laboratory tools.

Product Image-21573-153

VWR® Talon® Suspension Clamp

Catalog Number: (21573-153)
Supplier: VWR International
Description: Clamp holds thermometers, potash bulbs, or drying tubes 114 mm (4<sup>1</sup>/<sub>2</sub>") from the support rod.

Product available on GSA Advantage®


Image Unavailable-10230-890

Anti-CASP10 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10230-890)
Supplier: Bioss
Description: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.
Product Image-56614-110

ESD Safe Spray Cleaner, R & R Lotion

Supplier: R & R Lotion
Description: ESD safe screen and workstation cleaner is designed for general-purpose use, and helps remove oils and dirt from surfaces without leaving streaks.

Small Business Enterprise

Product Image-RC9191000330E3

Water USP, not sterile

Supplier: Ricca Chemical
Description: The bulk water for this product is manufactured by a continuous process that has been validated under cGMP to produce high purity Water meeting, as a minimum, the specifications below at time of packaging.
This water is not filled in a sterile environment or into sterile containers. This water is not sterile and should not be used for injection or parenteral solution preparation.

SDS Certificates Small Business Enterprise

Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
You must log in to order restricted items. We request that you provide the required business documentation to purchase this product for the first time.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
  • Government issued document with your organization's Resale Tax ID Number
  • Any other Government ID that includes the business name and address


VWR will not lift restrictions for residential shipping addresses.

-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is currently unavailable but limited stock may be available in our extended warehouse network. Please call 1-800-932-5000 and a VWR Customer Service Representative will help you.
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