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Supplier: G-Biosciences
Description: Suitable for molecular biology applications, which demand a high quality of water and assurance that the water is free from DNase and RNase contamination. Case of 4/ 1 Gallon cubes.
Catalog Number: (102886-584)
Supplier: R&D Systems
Description: Human LRP-5 Intracellular Domain Monoclonal antibody (Clone 747619), Isotype: Mouse IgG2B, Immunogen: E. coli-derived recombinant, Application: Western Blot, 100 UG


Catalog Number: (10230-890)
Supplier: Bioss
Description: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.


Catalog Number: (76491-624)
Supplier: VWR International
Description: Contains blue organic liquid against white back glass.


Catalog Number: (10231-012)
Supplier: Bioss
Description: Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.


Catalog Number: (10081-580)
Supplier: Proteintech
Description: Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN- inducible gene expression in response to viral infection. IRFs IRFs predominantly express in lymphoid tissues and play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3γ/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E). IRF-8/ICSCP is expressed predominately in hematopoietic cells and is further increased upon treatment with interferon (2111015,1460054). IRF-8 can function as a transcription repressor of ICS-containing promoters (1460054). Expression of IRF-8 can lead to the down-regulation of the anti-apoptotic protein Bcl-2 (14656881). Originally described as being induced by IFN-γ, IRF-8 expression is also elevated by IRF-α as well as IL-12 in NK and T cells (14581002). IRF-8 deficient mice have enhanced susceptibility to various pathogens and impaired production of interferons, as well as deregulated hematopoiesis that resembles chronic myelogenous leukemia (9120398). IRF-8 also regulates bone metabolism by suppressing osteoclast formation (19718038).This antibody specifically recognizes the 48kd IRF8 protein.


Supplier: Taylor-Wharton
Description: Taylor-Wharton/Worthington CryoStorage Systems are designed for applications where extremely low temperature storage of biological products is required

Supplier: Cytiva
Description: Water for Injection (WFI) quality water supports cell culture growth and biomanufacturing processes.

Catalog Number: (10084-098)
Supplier: Proteintech
Description: Caspase 9, apoptosis-related cysteine protease (CASP9,synonyms: MCH6, APAF3, APAF-3, ICE-LAP6, CASPASE-9c)is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Capase 9 is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.


Catalog Number: (89302-878)
Supplier: Genetex
Description: Rabbit polyclonal to Myosin 1C (MYO1C) (C-term)


Supplier: Thermco
Description: These high precision liquid-in-glass mercury thermometers are hand blown, which bear graduations, numbers and letters etched into the glass and filled with and inert gas above the mercury column

SDS

Supplier: Ricca Chemical
Description: The bulk water for this product is manufactured by a continuous process that has been validated under cGMP to produce high purity Water meeting, as a minimum, the specifications below at time of packaging.
This water is not filled in a sterile environment or into sterile containers. This water is not sterile and should not be used for injection or parenteral solution preparation.
Supplier: WORLD PRECISION INSTRUMENTS LLC
Description: The Meyhoefer curette has an ice cream scoop-shaped tip with semi-sharp edges designed for scraping. In ophthalmology, it may be used to scrape chalazion from the eyelids. It is perfect for incising cysts, large and small.

New Product

Supplier: Corning
Description: Cell culture grade water is high-quality water suitable for use as a solvent in the preparation of cell culture media and laboratory reagents.
Catalog Number: (60996-012)
Supplier: VWR International
Description: High-impact polystyrene rack has holes to fit 72 pegs.

Catalog Number: (76474-088)
Supplier: VWR International
Description: Versatile rack made of durable, easy to clean PS.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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