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Image Unavailable-10467-534

Anti-KCNMB1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10467-534)
Supplier: Bioss
Description: Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.
Image Unavailable-10375-154

Anti-Nesfatin-1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10375-154)
Supplier: Bioss
Description: Calcium-binding protein. May have a role in calcium homeostasis. Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).
Image Unavailable-102996-086

Human Parathyroid Hormone (1-34), Biotinylated, Biotin

Catalog Number: (102996-086)
Supplier: Anaspec Inc
Description: Parathyroid hormone (PTH) regulates the metabolism of calcium and phosphate. PTH and PTH-related polypeptide (PTHrP) play important roles in calcium homeostasis of bone, kidney, breast, and placenta; they signal via the PTH/PTHrP and PTH2 receptors. PTH(1–34) administration suppresses cardiovascular calcification and down-regulates aortic osteogenic programs driven by diabetes and dyslipidemia.
Sequence: Biotin-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF
MW: 4344.1 Da
% Peak area by HPLC: 95
Storage condition: -20° C
Product Image-10797-908

Human Recombinant S100B (from E. coli)

Catalog Number: (10797-908)
Supplier: Prosci
Description: S-100 protein beta chain (S100B),a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction,S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore,S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Image Unavailable-76118-448

Anti-MRGPRX1/3/4 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76118-448)
Supplier: Bioss
Description: There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.
Product Image-CAJT1792-4

Copper(II) chloride dihydrate 99.0-101.0%, BAKER ANALYZED® ACS, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: Crystals. Lot analysis on label.

Certificates

Product Image-10103-934

Anti-CAPN10 Rabbit Polyclonal Antibody

Catalog Number: (10103-934)
Supplier: Prosci
Description: CAPN10 is the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and located within the NIDDM1 region. Multiple alternative transcript variants encoding different isoforms have been described for this gene.
Image Unavailable-CAAAA12517-30

Phenothiazine 98+%

Supplier: Thermo Scientific Chemicals
Description: Acts on type I calcium/calmodulin dependent phosphodiesterase

Certificates

Image Unavailable-10664-982

Anti-ITPR1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10664-982)
Supplier: Bioss
Description: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Product Image-10095-270

Anti-STATH Rabbit Polyclonal Antibody

Catalog Number: (10095-270)
Supplier: Proteintech
Description: STATH belongs to the histatin/statherin family. STATH is a salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
Image Unavailable-CA1.03999.9025

Formaldehyde ≥37% in aqueous solution stabilized for histology acid-, calcium carbonate-free, Sigma-Aldrich®

Supplier: MilliporeSigma
Description: Formaldehyde Solution Min. 37% Free From Acid Stabilized with about 10% Methanol and Calcium Carbonate for Histology

SDS Certificates

Image Unavailable-CAAAJ63895-14

Clotrimazole

Supplier: Thermo Scientific Chemicals
Description: Specific inhibitor of calcium-activated potassium channels

Certificates

Image Unavailable-10390-054

Anti-ADCY5 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10390-054)
Supplier: Bioss
Description: This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Image Unavailable-10665-616

Anti-EFHD1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10665-616)
Supplier: Bioss
Description: The EF-hand domain is a twelve amino acid loop motif that is commonly found in proteins that participate in calcium-binding events within the cell. EF-hand domains generally exist in a pair that, together, form a stable four-helix bundle that enables the binding of calcium ions. Swiprosin-2, also known as EFHD1 (EF-hand domain-containing protein D1), SWS2, PP3051 or MST133, is a 239 amino acid protein that contains two EF-hand domains and is expressed in a wide variety of tissues, including brain, liver, heart, kidney, testis, ovaries and spleen. Expression of Swiprosin-2, a possible calcium-binding protein, is upregulated during neuronal differentiation, suggesting a role for Swiprosin-2 in brain development and maturation.
Product Image-76333-998

Anti-VISL1 Mouse Monoclonal Antibody [clone: 2D11]

Catalog Number: (76333-998)
Supplier: Biosensis
Description: Visinin (sometimes known as hippocalcin-like protein 3, HLP3, HPCAL3, HUVISL1, VLP-1, VILIP and VILIP-1) was originally isolated biochemically from chicken retina as a major protein of about 24kDa on SDS-PAGE (1). Following cloning and sequencing of visinin, several visinin like proteins were discovered by homology screening (2, 3). One of these, Visinin-like protein 1 is a small Calcium binding protein which is very abundant in the nervous system and is found only in neurons, though different neurons have different levels of expression (4, 5). It is particularly concentrated in cerebellar Purkinje cells, and tends to be most abundant in perikarya and dendrites. The protein belongs to the large superfamly of calmodulin and paravalbumin type proteins which function by binding Calcium ions. Calcium binding alters the confomation of these proteins and allow them to interact with other binding partners, the properties of which they may alter. Visinin-like protein 1 has four "EF hand" domains, which are negatively charged helix-turn-helix peptides which are responsible for Calcium binding. Visinin-like protein 1 is 191 amino acids in size and has a molecular weight on SDS-PAGE of 22kDa. The protein has recently been suggested to be a useful biomarker of Alzheimer's disease and traumatic brain injury (6, 7, 8).
Image Unavailable-77437-450

Anti-PLA2G4E Rabbit Polyclonal Antibody

Catalog Number: (77437-450)
Supplier: Bioss
Description: PLA2G4E is a calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position.
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