You Searched For: Boc-L-Lys-MCA


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Supplier: Bachem Americas
Description: Sequence: Boc-Lys(Tfa)-AMC

Catalog Number: (I-1570.0050BA)
Supplier: Bachem Americas
Description: Sequence: Boc-Leu-Lys-Arg-AMC


Supplier: Bachem Americas
Description: Sequence: Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂

Supplier: Bachem Americas
Description: Sequence: Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH₂
Synonym(s): Mca-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (667-676)-Lys(Dnp)-Arg-Arg amide

Catalog Number: (M-2455.0001BA)
Supplier: Bachem Americas
Description: FRET substrate for cathepsin D and E.


Catalog Number: (M-2420.0001BA)
Supplier: Bachem Americas
Description: Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP, SEVNLDAEF.


Catalog Number: (M-2485.0001BA)
Supplier: Bachem Americas
Description: Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP. The kinetic parameters of Mca-SEVNLDAEFK(Dnp) amide at pH 4.5 are Km = 4.5 µM and kcat = 0.25 min⁻¹.


Supplier: Bachem Americas
Description: Substrate V, Mca-RPPGFSAFK(Dnp), is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1) a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10⁷ M⁻¹s⁻¹ and 1.7 x 10⁶ M⁻¹s⁻¹ for the hydrolysis by neprilysin. This FRET substrate was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km= 218000 M⁻¹s⁻¹ and very slowly by gelatinase B (MMP-9) (kcat/Km= 10100 M⁻¹s⁻¹). There was no hydrolysis by MMP-1 and MMP-2. Mca-RPPGFSAFK(Dnp) has also found use as substrate for insulin-degrading enzyme (IDE) and ACE2.

Catalog Number: (M-2195.0001BA)
Supplier: Bachem Americas
Description: Specific highly fluorescent FRET substrate for the determination of caspase-1 (ICE) and caspase-1-like enzyme activities. Cleavage of Mca-YVADAPK(Dnp) at the P1 Asp residue results in a continuous fluorescent assay monitored at an emission wavelength of 392 nm. Caspase-3 (apopain, CPP-32) is only weakly active on this substrate. Both caspase-1 and caspase-3 are involved in apoptosis. A specific substrate for renal ACE 2.


Supplier: Bachem Americas
Description: Sequence: Boc-Leu-Gly-Arg-AMC

Supplier: Bachem Americas
Description: FRET substrate for angiotensin-converting enzyme 2 (ACE2). Mca-APK(Dnp)-OH is used for monitoring the activity of the enzyme in plasma, urine, heart, and lungs.

Supplier: Bachem Americas
Description: Sequence: Mca-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH₂
Synonym(s): NFF-3

Catalog Number: (I-1545.0050BA)
Supplier: Bachem Americas
Description: Sequence: Boc-Glu(OBzl)-Gly-Arg-AMC · HCl


Catalog Number: (77461-434)
Supplier: AAT BIOQUEST INC
Description: TF2-HQKLVFFAK-TQ2 [TF2-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-TQ2] has much stronger fluoresce upon protease cleavage than the commonly used FRET peptide MCA-HQKLVFFA (K-DNP), a secretase FRET peptide substrate.

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Supplier: Bachem Americas
Description: See also M-2460 and M-2465.

Supplier: Bachem Americas
Description: This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.

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