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Anti-HSP90 Rat Monoclonal Antibody [clone: 16F1]

Catalog Number: (89359-692)
Supplier: Genetex
Description: The 90kDa molecular chaperone family comprises several proteins including the 90kDa heat shock protein, Hsp90 and the 94kDa glucose regulated protein, grp94 which are major molecular chaperones of the cytosol and of the endoplasmic reticulum. In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and hsp90s which are encoded by separate genes. The amino acid sequence of human and yeast Hsp90a is 85% and 90% homologous to that of Hsp90s respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N terminal and C terminal regions which have been shown to contain independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.
Image Unavailable-89359-690

Anti-HSP90 Mouse Monoclonal Antibody [clone: AC88]

Catalog Number: (89359-690)
Supplier: Genetex
Description: The 90kDa molecular chaperone family comprises several proteins including the 90kDa heat shock protein, Hsp90 and the 94kDa glucose regulated protein, grp94 which are major molecular chaperones of the cytosol and of the endoplasmic reticulum. In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and hsp90s which are encoded by separate genes. The amino acid sequence of human and yeast Hsp90a is 85% and 90% homologous to that of Hsp90s respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N terminal and C terminal regions which have been shown to contain independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.
Product Image-16003-838

ErgoSCRUB® Scrubbing Handles and ScrubDISK® Pads, Foamtec International

Supplier: Foamtec International
Description: Ergonomically correct, disposable, and reusable scrubbing handles and pads for cleaning critical surfaces on process equipment in the semiconductor, flat-panel display, optical component, and hard disk drive industries.

Certificates

Product Image-47728-204

Interactive CD-ROM Courseware, American Compliance Systems

Catalog Number: (47728-204)
Supplier: American Compliance Systems
Description: Courses from The Interactive CD-ROM Training Library™ provide safety, health, and regulatory compliance training using a combination of audio, full-motion video, text, and colorful graphics.
Product Image-MFLX06368-55

Masterflex® Transfer Tubing, High-Purity PFA-450, Avantor®

Supplier: VWR International
Description: Won't crack under stress.

Product Image-77618-930

VWR® 700 Portable Dissolved Oxygen Meters

Supplier: VWR International
Description: The VWR-DO700 meter provide accurate and reliable measurements of dissolved oxygen concentration and dissolved oxygen saturation.

New Product

Product Image-MFLX32461-18

Masterflex® Direct-Read Variable-Area Flowmeters with Valve, English Units, Avantor®

Supplier: VWR International
Description: Meter with valve provides flow control through a highly durable meter body.

Product Image-76152-030

VWR® Turbidity Meter

Catalog Number: (76152-030)
Supplier: VWR International
Description: Autoranging from 0 to 1000 NTUs, the meter generates an accurate turbidity reading in seconds.
Product Image-77618-944

VWR® 950 Benchtop Dissolved Oxygen Meters

Supplier: VWR International
Description: <p>The VWR-DO950 meter provide accurate and reliable measurements of dissolved oxygen concentration and dissolved oxygen saturation.</p>

New Product

Product Image-23226-505

VWR® Traceable® Bench/Portable Conductivity Meter

Catalog Number: (23226-505)
Supplier: VWR International
Description: Designed to measure conductivity in water analysis, biology, chromatography, food, electronics, dairies, and PC-board rinsing, the conductivity meter provides results in conductivity (micromhos/cm and microsiemens/cm), resistivity (megohms), and dissolved solids (parts per million).

Certificates


Product Image-23226-504

Accessories for VWR® Bench/Portable Conductivity Meter

Catalog Number: (23226-504)
Supplier: VWR International
Description: Conductivity Meter

Certificates


Product Image-77618-978

VWR® 750 Benchtop Conductivity Meters

Supplier: VWR International
Description: The VWR-EC750 meter provide accurate and reliable measurements of conductivity, resistivity, TDS, salinity and temperature within one versatile meter.

New Product

Product Image-77618-940

VWR® 901 Portable Dissolved Oxygen Meter (Optical)

Catalog Number: (77618-940)
Supplier: VWR International
Description: The VWR-DO901 meter provide accurate and reliable measurements of dissolved oxygen concentration and dissolved oxygen saturation with an optical DO electrode.

New Product


Product Image-MFLX32755-18

Aalborg® Paddle Wheel Flowmeters for Monitoring and Control

Supplier: VWR International
Description: Meters provide visual and remote flow indication for numerous applications.

ISO9001

Product Image-89094-958

VWR® Traceable® Expanded Range Conductivity Meter

Catalog Number: (89094-958)
Supplier: VWR International
Description: Accurate answers in five seconds with a meter that automatically selects proper range and displays the exact answer.
Product Image-77618-986

VWR® 900 Portable Conductivity Meters

Supplier: VWR International
Description: The VWR-EC900 meter provide accurate and reliable measurements of conductivity, resistivity, TDS, salinity and temperature in any environment.

New Product

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
You must log in to order restricted items. We request that you provide the required business documentation to purchase this product for the first time.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
  • Government issued document with your organization's Resale Tax ID Number
  • Any other Government ID that includes the business name and address


VWR will not lift restrictions for residential shipping addresses.

-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is currently unavailable but limited stock may be available in our extended warehouse network. Please call 1-800-932-5000 and a VWR Customer Service Representative will help you.
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