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Catalog Number: (10073-244)
Supplier: Prosci
Description: Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine and serves as a marker of noradrenergic cells. The expression of DBH is elevated during stress.


Catalog Number: (76047-262)
Supplier: VWR International
Description: VWR® TraceableLIVE® is the simple, efficient, and reliable way to stay connected to critical environments, wherever you go.


Supplier: VWR International
Description: Isostatically molded in pure, FDA approved, PTFE. Machined base for good heat transfer. Molded-in pouring spout. Totally chemically resistant and inert. For use with 100ml Beaker, 65mm Diameter

Catalog Number: (10068-878)
Supplier: Prosci
Description: Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span


Catalog Number: (10070-264)
Supplier: Prosci
Description: Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span


Catalog Number: (89417-502)
Supplier: Prosci
Description: FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.


Catalog Number: (89417-504)
Supplier: Prosci
Description: FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.


Catalog Number: (470106-452)
Supplier: SI Manufacturing
Description: Four meter sticks in one and made of flexible plastic.


Supplier: YSI
Description: The EC300M offers convenient measurement of conductivity, specific conductance, salinity, total dissolved solids, and temperature in many field applications. Compared to the EcoSense® EC300A the EC300M features extended memory and simple data transfer with a micro-USB port.

Catalog Number: (10094-274)
Supplier: Proteintech
Description: Selenium (Se) is an essential trace element required for the biosynthesis of selenoproteins, and selenocysteine insertion sequence (SECIS) binding protein 2 (SECISBP2, or SBP2) represents a key trans-acting factor for the cotranslational insertion of selenocysteine into selenoproteins. Defects in SBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) associated with a reduction in type II iodothyronine deiodinase activity. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Cells depleted of SBP2 have increased levels of ROS, which lead to cellular oxidative stress manifested as DNA lesions, stress granules, and lipid peroxidation, induction of caspase- and cytochrome c-dependent apoptosis, indicating that SBP2 is required for protection against ROS-induced cellular damage and cell survival.


Catalog Number: (10086-638)
Supplier: Proteintech
Description: ERO1LB is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. It acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Glutathione may be required to regulate its activity in the endoplasmic reticulum. It may be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. It is required for the folding of cell, thereby being a source of oxidative stress. This antibody has no cross reaction to ERO1L.


Catalog Number: (470002-836)
Supplier: Skywill Far East Industries
Description: This plastic meter stick folds into fourths on three hinges.


Catalog Number: (10209-962)
Supplier: Boster Biological Technology
Description: Rabbit IgG polyclonal antibody for Stress-70 protein, mitochondrial(HSPA9) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.


Supplier: VWR International
Description: The VWR® Advanced Melting Point Apparatus is used in determining the purity of a sample and is optimized to quickly and efficiently heat up to 3 samples at one time.

Environmentally Preferable Product available on GSA Advantage®

Supplier: Chemglass
Description: Cylindrical style addition funnels feature a PTFE adjustable bore metering plug.

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Catalog Number: (CA470349-858)
Supplier: Hanna
Description: Top Seller! Designed to bring simplicity to pH testing during the any process, the HI98100 Hanna Checker® Plus pH Tester is designed for direct measurement. A replaceable electrode extends the life of your digital pH tester.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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