You Searched For: 3,6-Dibromothieno[3,2-b]thiophene

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Anti-IKBKE Mouse Monoclonal Antibody [clone: 6B4B5]

Catalog Number: (10070-598)

Supplier: Prosci

Description: Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degra-dation of IκB. IκB kinase beta(IKKbeta), previously designated CHUK, interacts with IκB-betaand specifically phosphorylates IκB-betaon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKbeta, IKKbetaand IKKgamma(also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKbetaand IKKbeta. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFbeta, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of IκBbetaon Ser32 and Ser36, and in NFκB activation, suggesting that IKK-i may act as an IκB kinase in the immune system.