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Catalog Number: (CAPIPA5-12888)
Supplier: Thermo Scientific
Description: PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.


Catalog Number: (76082-728)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.


Catalog Number: (76080-702)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.


Catalog Number: (10073-194)
Supplier: Prosci
Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.


Catalog Number: (76262-946)
Supplier: Rockland Immunochemical
Description: PIK3CB is a catalytic subunit of phosphoinositide-3-kinase beta. PIK3CB catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process. PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Furthermore, PI3KCB down regulation can suppress cell growth in malignant gliomas. Anti-PIK3C beta Antibody is suitable for researcher in Cancer, Immunology and Nuclear Signaling research.


Catalog Number: (KT885450-0025)
Supplier: DWK Life Sciences (KIMBLE)
Description: These tissue grinders combine both conical and cylindrical surfaces to effectively reduce tissue and produce a uniform homogenate. Grinding efficiency is greatly improved when this tube is used.


Supplier: TCI America
Description: [Substrate for beta-D-Glucosidase]
CAS Number: 2492-87-7
MDL Number: MFCD00006593
Molecular Formula: C12H15NO8
Molecular Weight: 301.25
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Melting point (°C): 167
Specific rotation [a]20/D: -102.5 deg (C=1, H2O)
Storage Temperature: 0-10°C
Supplier: Spectrum Chemicals
Description: Sucrose Octaacetate, NF is FDA approved for use as an food additive, Its bitter taste makes it ideal as a bitterant and aversive agent. It is used in pharmaceutical product containing ethanol to denature the ethanol and is industrially used as an ingredient in herbicides in an inert form. Spectrum Chemical NF products, including all NF Sucrose products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities. Storage temperature - HYGROSCOPIC: Keep tightly closed.
Catalog Number: (10417-334)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.


Catalog Number: (10417-336)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.


Catalog Number: (TCT1961-5G)
Supplier: TCI America
Description: (stabilized with CaCO3)
CAS Number: 572-09-8
MDL Number: MFCD00063254
Molecular Formula: C14H19BrO9
Molecular Weight: 411.20
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Color: White
Melting point (°C): 89
Specific rotation [a]20/D: 198 deg (C=3, CHCl3)
Storage Temperature: <0°C

SDS


Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00000892 Beilstein Registry No.: 471699
Catalog Number: (10451-386)
Supplier: Bioss
Description: FANK1 (fibronectin type III and ankyrin repeat domains 1), also known as HSD13, is a 345 amino acid nuclear and cytoplasmic testis-specific protein found primarily in pachytene spermatocytes and round spermatids. Containing six ANK repeats and a single fibronectin type-III domain, FANK1 undergoes alternative splicing events to form three isoforms. Possessing DNA binding activity, FANK1 is suggested to act as a transcription factor and may regulate gene expression during spermatogenesis. The gene encoding FANK1 maps to human chromosome 10, which contains over 800 genes and 135 million nucleotides, making up nearly 4.5% of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome.


Supplier: Eagle Group
Description: 14 Gauge Type 304 stainless steel top with 4¹/₂" backsplash at rear of table.

Supplier: Thermo Scientific
Description: Thermo Scientific Pierce Agaroses are highly purified and carefully blended formulations of regular that provide uniform lot-to-lot consistency for preparation of electrophoresis gels.
Catalog Number: (80089-092)
Supplier: Abgent
Description: Primary Rabbit Anti-NRG3 (Center) Reacts with Human


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