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Catalog Number: (10071-846)

Supplier: Prosci

Description: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

Catalog Number: (10071-842)

Supplier: Prosci

Description: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

Catalog Number: (10852-662)

Supplier: Sper Scientific

Description: Fits standard test tubes 16x50 mm or larger.

Catalog Number: (76263-572)

Supplier: BioFit

Description: MVMT™ stands for Movement, for ergonomic seating. The chairs are developed to address the unique ergonomic needs and working postures of users in technical environments specifically for healthcare, laboratory, cleanroom and standing-desk applications.

Catalog Number: (10102-846)

Supplier: Prosci

Description: CYBB is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H (+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD).Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Catalog Number: (10487-864)

Supplier: Bioss

Description: TM4-B, also known as TSPAN16 (tetraspanin-16) or TM4SF16 (transmembrane 4 superfamily member 16), is a 245 amino acid multi-pass membrane protein that belongs to the tetraspanin (TM4SF) family. Members of the TM4SF family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TM4-B is broadly expressed in most human tissues and cell lines including neural and bone marrow derived tissues. The gene that encodes TM4-B contains nearly 31,000 bases and maps to human chromosome 19p13.2. Chromosome 19 consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs).

Supplier: Bachem Americas

Description: Sequence: H-Glu-pNA

Catalog Number: (10094-838)

Supplier: Proteintech

Description: SMAD2, also named as MADH2 and MADR2, belongs to the dwarfin/SMAD family, contains 1 MH1 (MAD homology 1) domain and 1 MH2 (MAD homology 2) domain. SMAD2 is a receptor-regulated SMAD(R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. This protein may act as a tumor suppressor in colorectal carcinoma. It is phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255. In response to TGF-beta, It is phosphorylated on Ser-465/467 by TGF-beta and activin type 1 receptor kinases, and then able to interact with SMURF2, recruiting other proteins, such as SNON, for degradation. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, it is phosphorylated on Ser-240 by CaMK2. It is phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. In response to TGF-beta, it is ubiquitinated by NEDD4L, which promotes its degradation. In response to TGF-beta signaling, it is acetylated on Lys-19 by coactivators, which increases transcriptional activity. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human SMAD2.

Supplier: TCI America

Description: CAS Number: 7512-17-6
MDL Number: MFCD00136044
Molecular Formula: C8H15NO6
Molecular Weight: 221.21
Purity/Analysis Method: >98.0% (HPLC,N)
Form: Crystal
Melting point (°C): 205
Specific rotation [a]20/D: 40.5 deg (C=1, H2O)

Certificates

Catalog Number: (TCM1934-25G)

Supplier: TCI America

Description: CAS Number: 35450-36-3
MDL Number: MFCD00051594
Molecular Formula: C9H9BrO3
Molecular Weight: 245.07
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 162
Flash Point (°C): 110
Specific Gravity (20/20): 1.52

SDS Certificates

Catalog Number: (10096-186)

Supplier: Proteintech

Description: TOMM70A (or TOM70) is a mitochondrial import receptor responsible for the import of cytosol synthesized precursor proteins into the mitochondria. Tom70 is a member of the tetratricopeptide repeat (TPR) co-chaperone family and contains a conserved TPR clamp domain for interaction with Hsc70 and Hsp90. Recently overexpression of TOM70 has been linked to chemoresistance to drugs in breast cancer cell lines. It is also believed that Tom70 is significantly associated with breast cancer relapse and may predict the recurrence of ovarian cancer.

Supplier: Heathrow Scientific

Description: This magnetic induction stirrer is motor-less, using advanced coil technology that produces the strongest magnetic coupling and has no moving parts making this unit 100% wear-free and maintenance free. The magnetic coil technology works on the inductive principle with alternative current (AC) as its driving force.

Catalog Number: (H-1604.1000BA)

Supplier: Bachem Americas

Description: These synthetic oligopeptides correspond to a region of high amino-acid sequence similarity between uteroglobin and lipocortin I. They possess a potent anti-inflammatory activity in vivo and are strong inhibitors of phospholipase A₂ (PLA₂) in vitro. The name 'antiflammins' is proposed for these peptides, which are a valuable model for the development of novel anti-inflammatory agents of therapeutic importance. See also Cortistatin-29, H-6458, and Thymic Factor, H-4865.

Catalog Number: (E-1905.0050BA)

Supplier: Bachem Americas

Description: Sequence: H-Glu(OMe)-OMe · HCl

Catalog Number: (10097-228)

Supplier: Proteintech

Description: YWHAZ (also known as 14-3-3 zeta) is a member of 14-3-3 proteins which were the first phosphoserine/phosphothreonine-binding proteins to be discovered. 14-3-3 family members interact with a wide spectrum of proteins and possess diverse functions. Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers. 14-3-3 proteins display the highest expression levels in the brain, and have been implicated in several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This antibody was raised against the full-length YWHAZ.

Catalog Number: (10085-368)

Supplier: Proteintech

Description: Chemokines direct the trafficking of white blood cells in immune surveillance, playing a key role in inflammatory and infectious diseases such as AIDS. The human CX3C chemokine carries the chemokine domain on top of an extended mucin-like stalk. CX3CL1 is synthesized as a 50-75kDa precursor and undergoes glycosylation to yield two mature forms: a 100kDa cell membrane bound form and an 85kDa soluble form which is released from the cell surface.The soluble CX3C chemokine has potent chemoattractant activity for T cells and monocytes, and the cell-surface-bound protein, which is induced by primary proinflammatory signals in activated primary endothelial cells, promotes strong adhesion of those leukocytes.