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Zymoclean™ Gel DNA Recovery Kits, Zymo Research

Supplier: Zymo Research

Description: The Zymoclean Gel DNA Recovery Kits provide for the rapid purification of high quality DNA from TAE/TBE-bufffered agarose gels.

Anti-BRSK2 Rabbit Polyclonal Antibody

Catalog Number: (10749-884)

Supplier: Prosci

Description: BRSK2 Antibody: BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.

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VWR® Disposable Scalpels with Measurements

Catalog Number: (76457-500)

Supplier: VWR International

Description: VWR® Sterile Disposable Scalpels are mounted on plastic handles with fluted finger-grips.

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Dithiothreitol (DTT, Cleland's reagent) ≥99.0%, Biotech Reagent, J.T.Baker®

Catalog Number: (CAJTF781-5)

Supplier: VWR International

Description: White crystals. Keep material refrigerated between 2 to 8°C.

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Anti-HAP1 Rabbit Polyclonal Antibody

Catalog Number: (89416-268)

Supplier: Prosci

Description: HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

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VWR® Basic Reach-In Freezers with Natural Refrigerant

Catalog Number: (10018-870)

Supplier: VWR International

Description: Upright freezers with 1-, 2-, or 3-doors, these freezers maintain –10 °F (–23.3 °C).

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Human Recombinant IL-17AF (from E. coli)

Supplier: VWR International

Description: Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses.

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Accessories for VWR® Chromatography Refrigerators with Glass Doors

Supplier: VWR International

Description: Full shelf kit for 651 L refrigerators, 22.56×23.25", 10 lbs, additional full white wire shelf can be ordered for any GDM-23 model

VWR® Reach-In Refrigerators with Solid Doors and Natural Refrigerant

Catalog Number: (10791-630)

Supplier: VWR International

Description: Units feature a stainless steel front exterior with white aluminum interior and stainless steel floor.

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VWR® Extra Shelves for VWR® Standard Chromatography Units

Catalog Number: (76520-078)

Supplier: VWR International

Description: Includes an extra wire frame shelf made to fit VWR® Standard Series Chromatography units.

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VWR® Carbon Steel Scalpel Blades

Catalog Number: (76457-464)

Supplier: VWR International

Description: VWR® Carbon Steel Scalpel Blades are made from high quality carbon steel and sharpened to perfection.

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Anti-PSEN1 Rabbit Polyclonal Antibody

Catalog Number: (10748-676)

Supplier: Prosci

Description: Presenilin1 Antibody: Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimer's disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease. Multiple isoforms of presenilin1 are known to exist. This antibody has no cross-reactivity to presenilin2.