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Supplier: Enzo Life Sciences
Description: Immunosuppressant.

Catalog Number: (10070-930)
Supplier: Prosci
Description: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.


Catalog Number: (89415-366)
Supplier: Prosci
Description: IRAK-2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.


Supplier: Thermo Scientific Chemicals
Description: trans-4-Cyanocyclohexylamine hydrochloride, 97%
Supplier: Thermo Scientific Chemicals
Description: Fieser: 14,201 16,204
Supplier: Enzo Life Sciences
Description: Precursor to 1α,25-dihydroxyvitamin D₃

Catalog Number: (10749-636)
Supplier: Prosci
Description: SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.


Catalog Number: (TCA1107-025ML)
Supplier: TCI America
Description: CAS Number: 2623-23-6
MDL Number: MFCD00001482
Molecular Formula: C12H22O2
Molecular Weight: 198.31
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 228
Flash Point (°C): 98
Specific Gravity (20/20): 0.93
Specific rotation [a]20/D: -79.5 deg (neat)

Supplier: Thermo Scientific Chemicals
Description: A lipotropic agent
Catalog Number: (89415-454)
Supplier: Prosci
Description: IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.


Catalog Number: (89149-418)
Supplier: Enzo Life Sciences
Description: Specific Na+/K+-ATPase inhibitor.


Supplier: Thermo Scientific Chemicals
Description: Potent inhibitor of protein synthesis in bacteria
Catalog Number: (89150-300)
Supplier: Enzo Life Sciences
Description: White to off-white crystalline powder


Catalog Number: (76100-420)
Supplier: Bioss
Description: This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.


Supplier: Enzo Life Sciences
Description: A potent, irreversible inhibitor of various plant β-glucosidases and mammalian glucocerebrosidase. Has been employed in in vitro and animal models for Gaucher’s disease. It raises intracellular levels of glucosylceramide by inhibiting glucosylceramidase.

Supplier: TCI America
Description: CAS Number: 14073-97-3
MDL Number: MFCD00001634
Molecular Formula: C10H18O
Molecular Weight: 154.25
Purity/Analysis Method: >90.0% (GC)
Form: Clear Liquid
Boiling point (°C): 88
Flash Point (°C): 72
Specific Gravity (20/20): 0.89
Specific rotation [a]20/D: -19.5 deg (neat)
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