FLUOR DE LYS® HDAC8 Fluorometric Drug Discovery Kit, Enzo Life Sciences

Supplier: Enzo Life Sciences

FLUOR DE LYS® HDAC8 Fluorometric Drug Discovery Kit, Enzo Life Sciences

FLUOR DE LYS® HDAC8 Fluorometric Drug Discovery Kit, Enzo Life Sciences

BML-AK518-0001

89156-514EA 1370 CAD

89156-514

FLUOR DE LYS® HDAC8 Fluorometric Drug Discovery Kit, Enzo Life Sciences

Assays Enzyme Assays

A Fluor de Lys® fluorescent assay system

Useful for inhibitor screening or characterizing enzyme kinetics
Includes optimal substrate selected from a panel of acetylated sites in p53 and histones
Supplied with enough recombinant enzyme for 96 assays (1 x 96-well plate)

The HDAC8 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC8 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or activators or kinetic assay of the enzyme under varying conditions. The Fluor de Lys® HDAC8 assay is based on the Fluor de Lys® Substrate and Fluor de Lys® Developer combination. The assay procedure has two steps. First, the Fluor de Lys® Substrate, which comprises an acetylated lysine side chain, is incubated with HDAC6. Deacetylation of the substrate sensitizes the substrate so that, in the second step, treatment with the Fluor de Lys®Developer produces a fluorophore.

Delivery information: Kit contains HDAC8 (human) (recombinant), Fluor de Lys®-HDAC8 substrate and developer II, Assay buffer, Trichostatin A (HDAC inhibitor), White and clear 1/2-vol. 96-well plates.

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