You Searched For: Thermo Scientific

Catalog Number: (CAPI77680)

Supplier: Thermo Scientific

Description: Purified (unconjugated) Thermo Scientific Pierce Recombinant Protein L is useful as the basis for preparing various kinds of probes or affinity media for detection or purification of mouse and human antibodies in immunoassays and antibody purification protocols.

SDS

Catalog Number: (CAPIMA5-14572)

Supplier: Thermo Scientific

Description: MA5-14572 targets CD23 in IHC (P), Western blot and FACS applications and shows reactivity with Human and Mouse samples. The MA5-14572 immunogen is recombinant protein encoding human CD23 48-248aa. CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma.

Catalog Number: (CAPIPA5-18167)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology. Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Catalog Number: (CAPIPA5-18170)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, human, porcine and rat based on sequence homology.

Catalog Number: (CAPIPA5-18160)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Catalog Number: (CAPIPA5-18157)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. STXBP6 binds components of the SNARE complex and may be involved in regulating SNARE complex formation .

Catalog Number: (CAPIPA5-18165)

Supplier: Thermo Scientific

Description: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11. 23

Catalog Number: (CAPIPA5-18163)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with bovine and canine based on sequence homology. The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.

Catalog Number: (CAPIPA5-14559)

Supplier: Thermo Scientific

Description: PTPN7 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN7 is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP has been shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating the molecules related to MAP kinase pathway.

Catalog Number: (CAPIPA5-12447)

Supplier: Thermo Scientific

Description: NPM1 is a ubiquitously expressed nucleolar protein that shuttles between the nucleus and cytoplasm. It is implicated in multiple functions, including ribosomal protein assembly and transport, control of centrosome duplication, and regulation of the tumor suppressor ARF. NPM1 mutations that relocalize NPM1 from the nucleus into the cytoplasm are associated with development of acute myeloid leukemia.

Catalog Number: (CAPIMA1104HRP)

Supplier: Thermo Scientific

Description: This Antibody detects Oct4/Pou5F1 in huThis Antibody detects a band at 40 kDa in huIt has been linked to tumor formation.

Catalog Number: (CAPIMA1016D488)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse, rat and cow based on sequence homology. The protein encoded by this gene is a member of the cyclin-dependent protein kinase family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.

Catalog Number: (CAPIMA1144D550)

Supplier: Thermo Scientific

Description: Immunofluorescence of MA1-144-D550 shows positive staining of SSEA-5 in human embryonal carcinoma NCCIT cells. Stage-Specific Embryonic Antigen-5 (SSEA-5) is an oligosaccharide that can be part of glycosphingolipids and glycoproteins. It contains the motif Fuc1-2Gal-beta1-3GlcNAc-beta, which is characteristic of H-1 antigens. SSEA-5 is found in the inner cell mass of the human blastocyst during embryogenesis, on undifferentiated human embryonic stem cells and on the surface of induced pluripotent cells. SSEA-5 was found to proceed the loss of other known stem cell markers and the combination of SSEA-5 with either CD9 and CD90 or CD50 and CD200 was superior in identifying and eliminating rare undifferentiated human ES cells from differentiated cell populations than the use of other established stem cell markers.

Catalog Number: (CAPIMA1017HRP)

Supplier: Thermo Scientific

Description: This Antibody has been successfully used in ICC/IF applications with human and mouse samples. This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Catalog Number: (CAPIPA525803)

Supplier: Thermo Scientific

Description: Host: Rabbit Species Reactivity: Human (Hu) Mouse (Ms) Immunogen: Synthetic peptide from the Central region of human ACSF3 conjugated to KLH.

Catalog Number: (CAPIPA5-13649)

Supplier: Thermo Scientific

Description: This antibody is predicted to react with mouse based on sequence homology. PAX4 is a member of the paired box (PAX) family of transcription factors. These proteins play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.