You Searched For: STEMCELL Technologies

Catalog Number: (MSPP-02002)

Supplier: STEMCELL Technologies

Description: For detection and measurement of human interferon-gamma.

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Catalog Number: (MSPP-60141)

Supplier: STEMCELL Technologies

Description: Rabbit polyclonal antibody against mouse SHIP, unconjugated.

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Catalog Number: (MSPP-60016)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD4, unconjugated.

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Catalog Number: (MSPP-781001006)

Supplier: STEMCELL Technologies

Description: RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall <i>et al.</i>). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv <i>et al.</i>; Maghazachi <i>et al.</i>). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi <i>et al.</i>).

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Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG1, antibody against mouse IFN-gamma, APC-conjugated.

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Supplier: STEMCELL Technologies

Description: Interleukin 13 (IL-13) is a cytokine important in type 2 immune responses and is expressed by T helper type 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) (Pulendran and Artis). IL-13 binds a receptor composed of IL-4Ra and IL-13Ra1 or IL-13Ra2 (Wynn 2003). IL-13 receptor is expressed on B cells and promotes B cell proliferation, induces class switching to IgG4 and IgE, and functions in the recruitment and activation of IgE-producing B cells (Hershey). The receptor is also expressed on basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells (Hershey). Signaling through the IL-13 receptor activates the JAK/STAT and IRS-1/IRS-2 pathways. <i>in vivo</i>, IL-13 has a role in resistance to extracellular helminth parasites by regulating gastrointestinal parasite expulsion, as well as in airway hyperresponsiveness, allergic inflammation, tissue remodeling, tumor cell growth, and fibrosis (Wynn 2015). Secreted IL-13 is a protein consisting of 112 amino acids with a molecular mass of 10 kDa (Hershey). Human IL-13 is not species-specific but has greater activity on human cells compared to mouse cells (Hershey).

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Catalog Number: (MSPP-60096)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD33, unconjugated.

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Catalog Number: (MSPP-100-1464)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal antibody against human, cynomolgus IL-2, FITC-conjugated.

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Catalog Number: (MSPP-780331006)

Supplier: STEMCELL Technologies

Description: Interleukin 17A (IL-17A) is the founding member of the family of cytokines that includes Interleukin 17B through Interleukin 17F. It is a potent proinflammatory cytokine that plays a key role in defense against pathogens. IL-17A and IL-17F signal as homodimers or heterodimers through the same receptor, and activate NF-kB, MAPK, and C/EBP pathways (Gaffen). IL-17A receptor is expressed on a variety of cell types, including hematopoietic cell compartments. IL-17A is produced by T helper 17 cells, CD8+ T cells, γδ T cells, natural killer T cells, B cells, neutrophils, innate lymphoid cells and mesenchymal stromal cells (MSCs; Zenobia and amp; Hajishengallis; Mojsilovic <i>et al.</i>). IL-17A receptor is expressed at particularly high levels on stromal cells, including MSCs. IL-17A increases the frequency and the average size of colony-forming units-fibroblast derived from bone marrow, as well as the proliferation of bone marrow-derived MSCs. IL-17A suppresses osteogenic differentiation and bone formation of bone marrow-derived MSCs. The action of IL-17A on hematopoiesis is deeply reliant on the microenvironment and the induction of other regulators. In healthy mouse bone marrow, IL-17A stimulates myeloid and early stage erythroid progenitor cells but inhibits late stage erythroid progenitor cells (Mojsilovic <i>et al.</i>).

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Catalog Number: (MSPP-100-0443)

Supplier: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal IgG antibody against mouse CD11c, FITC-conjugated.

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Catalog Number: (MSPP-100-1610)

Supplier: STEMCELL Technologies

Description: Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, unconjugated.

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Catalog Number: (MSPP-780271006)

Supplier: STEMCELL Technologies

Description: Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits. IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ. The IL-12 receptor is expressed on T, NK, and dendritic cells. Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford <i>et al.</i>). It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann and Rüde). Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford <i>et al.</i>).

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Catalog Number: (MSPP-60019)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against human, mouse, cat CD45R (B220), unconjugated.

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Catalog Number: (MSPP-60005)

Supplier: STEMCELL Technologies

Description: Mouse monoclonal IgG1 antibody against human, chimpanzee CD19, unconjugated.

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Catalog Number: (MSPP-60017)

Supplier: STEMCELL Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD4, unconjugated.

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Catalog Number: (MSPP-18004)

Supplier: STEMCELL Technologies

Description: The EasySep™ Multistand allows the separation of up to four samples at one time.

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