You Searched For: Genscript

Catalog Number: (89495-090)

Supplier: Genscript

Description: THE™ NWSHPQFEK Tag antibody [Biotin], mAb, Mouse recognizes N-terminal and C-terminal Strep II tagged fusion proteins.

Catalog Number: (77007-620)

Supplier: Genscript

Description: Omalizumab with trade name Xolair, is an FDA-approved drug for the treatment of moderate to severe persistent asthma in adults and adolescents (12 years of age and above). It is a recombinant humanized monoclonal antibody. It selectively binds to human immunoglobulin E (IgE). Omalizumab inhibits the binding of IgE to the high-affinity IgE receptor (FcεRI) on the surface of mast cells and basophils. Anti-Omalizumab Antibody (10G3), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Omalizumab.

Catalog Number: (77007-606)

Supplier: Genscript

Description: Ustekinumab with trade name Stelara, is an FDA-approved drug to Crohn's disease, Ulcerative Colitis, Plaque Psoriasis and Psoriatic Arthritis, targeting both interleukins (IL)-12 and IL-23. Ustekinumab is a fully human immunoglobulin G1 kappa mAb that binds to IL-12 and IL-23. Ustekinumab binds to the p40 subunit common to IL-12 and IL-23 and prevents their interaction with the IL-12 receptor β1 subunit of the IL-12 and IL-23 receptor complexes, thereby disrupting the proinflammatory pathway. GenScript Anti-Ustekinumab Antibody, pAb, Rabbit is produced from sera of a rabbit immunized with Ustekinumab.

Catalog Number: (77007-548)

Supplier: Genscript

Description: CD4 (cluster of differentiation 4) is a single glycoprotein with a molecular weight of 59 kDa. CD4 antigen is expressed on the surface of T helper cells, monocytes and macrophages. CD4 recognizes antigens associated with MHC class II molecules, and participates in cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary receptor for HIV, binding to HIV gp120. CD4+ T helper cells bind and activate B cells to create immunoglobulins.

Catalog Number: (77007-496)

Supplier: Genscript

Description: Adeno-associated virus type 2 (AAV2) is a valuable vector for gene therapy. It is one member of the human parvovirus family which depends on co-infection with helper viruses such as adenovirus or herpes virus for efficient reproduction. The AAV2 capsid (intact particle) comprises three types of subunits, VP1, VP2, and VP3, a total of 60 copies in a ratio of 1:1:8 (VP1:VP2:VP3). For the application of AAV2 vector in gene therapy, the determination of total capsid titer is essential, accurate characterization and quantification of purified AAV2 particle product represent a critical step for clinical application. GenScript Anti-AAV2 (intact particle) Antibody (2C4), mAb, Mouse is produced from cell culture <i>in vitro</i> under conditions free from animal-derived components.

Catalog Number: (77007-564)

Supplier: Genscript

Description: Palivizumab with trade name Synagis, is an FDA-approved drug for the prevention of respiratory syncytial virus (RSV) infections. It is a recombinant humanized IgG1 kappa isotype monoclonal antibody. Palivizumab binds the RSV envelope fusion protein (RSV F) on the surface of the virus and blocking a critical step in the membrane fusion process. Anti-Palivizumab Antibody (2F12), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Palivizumab.

Catalog Number: (77007-600)

Supplier: Genscript

Description: A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Catalog Number: (77007-546)

Supplier: Genscript

Description: Etanercept with trade name Enbrel, is an FDA-approved drug to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. Etanercept is a fusion protein made from the combination of two naturally occurring soluble human 75-kilodalton TNF receptors linked to an Fc portion of an IgG1. Etanercept treats autoimmune diseases by interfering with tumor necrosis factor-alpha (TNF alpha, a soluble inflammatory cytokine) by acting as a TNFalpha inhibitor.Anti-Etanercept Antibody (4H5), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Etanercept.

Catalog Number: (77007-480)

Supplier: Genscript

Description: A camelid single-domain antibody (sdAb, called Nanobody by Ablynx, the developer) is a peptide chain of about 110 amino acids long, comprising one variable domain of a heavy-chain antibody, these are called VHH fragments. Like a whole antibody, it is able to bind selectively to a specific antigen. Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic uses due to their small size, simple production, and high affinity. However, their sequences may increase the risk of immunogenicity and anti-drug antibody (ADA) development in humans, and thus, sdAbs are routinely humanized during development.

Catalog Number: (77007-502)

Supplier: Genscript

Description: CD3 is a member of the immunoglobulin superfamily, expressed on T cells. It is composed of four distinct chains (ε, γ, δ, ζ). CD3 antigen can form a complex with the T cell receptor (TCR) to generate an activation signal in T cells, which plays an important role in TCR signal transduction and both cytotoxic T cell ( CD8 + naïve T cells) and T helper cells (CD4+ naive T cells) activation.

Catalog Number: (77007-628)

Supplier: Genscript

Description: Eculizumab with trade name Soliris, is an FDA-approved drug to treat paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and neuromyelitis optica. Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5. Eculizumab specifically binds to the terminal complement component 5, or C5. Binding to this protein prevents the activation of a complement terminal complex, which is used to treat a number of autoimmune conditions. Anti-Eculizumab Antibody (4F6), mAb, Mouse is produced from a hybridoma resulting from the fusion of partner and B-lymphocytes obtained from a mouse immunized with Eculizumab.

Catalog Number: (76198-914)

Supplier: Genscript

Description: GenScript MonoRab™ DYKDDDDK tag antibody [HRP], mAb, rabbit specifically recognizes DYKDDDDK tags placed at C-terminal, N-terminal and internal regions of DYKDDDDK fusion proteins.

Supplier: Genscript

Description: Electrophoresis system, Combined gel staining and blot processing system

Catalog Number: (76197-322)

Supplier: Genscript

Description: GenScript MonoRab™ Rabbit Anti-Camelid VHH Antibody [iFluor555], mAb is specific for Camelid VHH antibody (Alpaca, Llama and Camel). The monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken, goat or human immunoglobulins.

Catalog Number: (76197-320)

Supplier: Genscript

Description: GenScript MonoRab™ Rabbit Anti-Camelid VHH Antibody [iFluor488], mAb is specific for Camelid VHH Antibody (Alpaca, Llama and Camel). The monoclonal antibody has no cross-reactivity with mouse, rat, rabbit, chicken, goat or human immunoglobulins.

Catalog Number: (76197-354)

Supplier: Genscript

Description: The product is specific for Bevacizumab but can't block vascular endothelial growth factor 165 (VEGF 165). The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A01896-40, MonoRabTM Anti- Bevacizumab Antibody (46E3)[Biotin], mAb, Rabbit.