You Searched For: Enzo Life Sciences

Supplier: Enzo Life Sciences

Description: Potent and selective serotonin uptake inhibitor

Catalog Number: (89160-692)

Supplier: Enzo Life Sciences

Description: Sodium channel blocker. Clinically useful local anesthetic.

Catalog Number: (89160-830)

Supplier: Enzo Life Sciences

Description: Serotonin receptor ligand.

Supplier: Enzo Life Sciences

Description: Bilobalide is a terpenoid isolated from <i>Ginkgo biloba</i>. It has been proposed to exert trophic and protective effects on neurons. It increases the sensitivity of mouse pancreatic β cells to glucose and displays protective effects during hypoxia.

Catalog Number: (89160-688)

Supplier: Enzo Life Sciences

Description: Na+ channel blocker, K+ channel activator

Catalog Number: (89162-246)

Supplier: Enzo Life Sciences

Description: A proline-arginine-rich peptide antibiotic. PR39 inhibits DNA and protein synthesis and the degradation of HIF-1alpha. It has been reported to bind to the alpha7 subunit of the 26S proteasome, blocking degradation of the NK-κB inhibitor, IκBα by the ubiquitin-proteasome pathway without affecting overall proteasome activity. More recent studies have demonstrated it to be an efficient inhibitor of all activities of the 20S proteasome.

Catalog Number: (89162-354)

Supplier: Enzo Life Sciences

Description: Host: Mouse, Isotype: IgG1

Catalog Number: (89161-768)

Supplier: Enzo Life Sciences

Description: PP2A inhibitor

Supplier: Enzo Life Sciences

Description: The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM).

Supplier: Enzo Life Sciences

Description: The tumor suppressor CYLD is a deubiquitinylating enzyme (DUB) that antagonises NF-κB and JNK signaling by disassembly of Lys63-linked ubiquitin chains synthesised in response to cytokine stimulation. The DUB activity of CYLD is mediated by its C-terminal ubiquitin specific protease (USP) domain, pathogenic truncations and mutations of which are associated with the hypertrophic skin tumor cylindromatosis through disruption of the USP domain and subsequent loss of CYLD catalytic activity.

Supplier: Enzo Life Sciences

Description: The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation. The catalytic core of this unusually large (2000kDa, 450Å in length) complex is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. 20S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome.A second activator which can associate with the 20S proteasome in the absence of ATP is known as PA28 or the 11S regulator. The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (now referred to as PA28γ). These subunits, with an apparent relative molecular weight of approximately 29kDa, form ringlike heteromeric complexes of ~200kDa possibly with an α3β3 stoichiometry. Electron microscopic studies have shown PA28 to be a ring shaped particle which, like the 19S, caps the 20S proteasome, by binding to the α-rings, at both or either end. The complex may, however, be readily dissociated. The finding that PA28 modulates the proteasome-catalysed production of antigenic peptides presented to the immune system on MHC class I molecules indicates a cellular function of this activator in antigen processing.

Supplier: Enzo Life Sciences

Description: PP2A inhibitor

Supplier: Enzo Life Sciences

Description: Highly selective plasma kallikrein inhibitor (Ki = 0.81 µM). Can be used for affinity purification of kalikrein. Suppresses collagen-induced arthritis in a mouse model. Synergizes with NO donors producing antithrombotic effects ex vivo.

Supplier: Enzo Life Sciences

Description: Caspase inhibitor

Supplier: Enzo Life Sciences

Description: Host: Rabbit

Catalog Number: (89162-776)

Supplier: Enzo Life Sciences

Description: Host: Mouse, Isotype: IgG2b