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Supplier: VWR International
Description: Mini-dome protrusions inhibit suction blockage.

Catalog Number: (76118-502)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.


Catalog Number: (89087-696)
Supplier: VWR International
Description: These films are 240 µm thick white vinyl with adhesive, for use with white microplates.

Catalog Number: (76491-690)
Supplier: VWR International
Description: Choice of vibration, sound, and/or light alarms make this timer ideal for use in high noise locations.


Supplier: VWR International
Description: Ensure a tight seal in your sanitary fluid line.
Supplier: VWR International
Description: VWR® Made in USA sterile sleeves are an ideal option for single-use needs. Made with the specially formulated alliance breathable microporous fabric.
Catalog Number: (76470-704)
Supplier: VWR International
Description: VWR® Made in USA Sterile Sleeves are an ideal option for single-use needs. Made with the specially formulated Alliance breathable microporous fabric.


Catalog Number: (76470-786)
Supplier: VWR International
Description: VWR® Made in USA SMS Sleeves are an ideal option for single-use needs.


Catalog Number: (34107-923)
Supplier: Thermo Fisher Scientific
Description: This reference half-cell electrode helps to precisely measure with ion-selective electrodes. Ideal for ISE determinations and routine pH measurements with Orion™ 910100 electrodes.


Catalog Number: (10451-520)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.


Supplier: VWR International
Description: Aluminium foils, 75.7 µm thick, for use with 96- or 384-well plates. Fit inside the rim of raised rim plates. These foils have one partial-width end tab. Available non sterile only.
Supplier: VWR International
Description: Sterile PETG containers with weldable tubing provide the maximum amount of flexibility and reliability.
Supplier: VWR International
Description: Ion chromatography (IC) is an analytical process for the separation of ions based on charge affinity. IC can be used for a variety of different kinds of charged analytes from single elements to large proteins.

SDS

Supplier: AVANTOR FLUID HANDLING, LLC
Description: Avantor's high-pressure single-use transfer hose with Avantor SterilEnz™ connections maintain the durability of high-pressure hose products while providing the benefits and flexibility of single-use assemblies.
Supplier: VWR International
Description: Shoe covers are manufactured using a unique flash spinning process that creates an excellent barrier against nonhazardous liquids and microorganisms as well as dry particles down to 0.5µm.
Catalog Number: (36934-176)
Supplier: VWR International
Description: Non-invasive, no-touch measurements are ideal for food preparation, life sciences, pharmaceuticals, petroleum products, cleanrooms, electronics, and field use.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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