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Product Image-10749-850

Anti-SCO1 Rabbit Polyclonal Antibody

Catalog Number: (10749-850)
Supplier: Prosci
Description: SCO1 Antibody: Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody. This SCO1 antibody has no cross-reactivity to SCO2.
Product Image-76460-432

Mini LABOPORT™ N96 Diaphragm Vacuum Pump, KNF

Catalog Number: (76460-432)
Supplier: KNF Neuberger Inc.
Description: Very compact, chemically resistant and oil-free diaphragm vacuum pump with manual speed control for adjusting the pump capacity to your specific application.
Product Image-76460-434

LABOPORT™ N820G and N840G Vacuum Diaphragm Pumps, KNF

Supplier: KNF Neuberger Inc.
Description: Ideal for a range of lab applications such as rotary evaporation, degassing and vacuum ovens.

Product Image-89416-206

Anti-SCO1 Rabbit Polyclonal Antibody

Catalog Number: (89416-206)
Supplier: Prosci
Description: SCO1 Antibody: Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody. This SCO1 antibody has no cross-reactivity to SCO2.
Product Image-82004-054

Mini LABOPORT™ UN816KTP Diaphragm Vacuum Pumps, KNF

Supplier: KNF Neuberger Inc.
Description: UN816 diaphragm pumps are double-head, dry-running devices used in a wide range of laboratory applications. They transfer and pump down without contamination. The heart of these very compact pumps is a KNF structured diaphragm.

Product Image-26678-052

Mini LABOPORT™ UN811 Vacuum Diaphragm Pumps, KNF

Supplier: KNF Neuberger Inc.
Description: UN811 diaphragm pumps are single head, dry running devices used in a wide range of laboratory applications. They transfer, compress and pump down without contamination. The heart of these very compact pumps is a KNF structured diaphragm.

Certificates

Product Image-89153-246

Anti-BSEP Mouse Monoclonal Antibody

Catalog Number: (89153-246)
Supplier: Enzo Life Sciences
Description: Bile Salts
Bile salts are important physiological agents that serve a number of functions, including absorption, solubilization, transport and secretion of lipids. In the liver, they participate in the generation of bile flow and the secretion of cholesterol and phospholipids, such as phosphatidylcholine. When released into the intestine, they facilitate the uptake of cholesterol, fat-soluble vitamins and other lipids. Moreover, the biosynthesis of bile acids from cholesterol is the most significant pathway for the elimination of cholesterol from the body. However, because of their detergent properties, bile acids are inherently cytotoxic and disruptions in their normal transport or secretion can result in a variety of pathophysiological conditions.

BSEP
Bile formation is an important function of the liver. It is mediated by hepatocytes which generate bile flow within the bile canaliculi by continuous vectorial secretion of bile salts and other solutes across their canalicular (apical) membrane. Bile secretion is mediated by several ATP-binding cassette (ABC) transporters located in the canalicular membrane of hepatocytes. Among these ABC transporters, the bile salt export pump (BSEP or ABCB11) represents the primary, if not sole transport system for the canalicular excretion of bile salts. Bile secretory failure results in cholestasis and progressive familial intrahepatic cholestasis (PFIC) in infancy represents a group of inherited cholestatic diseases that are classified into three subtypes. One of these subtypes, PFIC II, is associated with mutations in the BSEP gene. PFIC patients with mutations in the BSEP gene have normal γ-glutamyltransferase activity, low concentrations of bile salts in bile, and an absence of bile duct proliferation. Additionally, human obesity is associated with altered cholesterol homeostasis including increased production and turnover, as well as secretion of excess cholesterol from the liver into bile.

BSEP is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-ancoring domain and an ATP-binding cassette (ABC) domain. The membrane-anchoring domain is composed of six helixes buried in the lipid bilayer of the plasma membrane and the ATP binding ABCs are exposed to the cytosol. The membrane-anchoring domain helixes are thought to form channels spanning the plasma membrane.
Image Unavailable-CAPIPA5-18315

Anti-ABCC4 Goat Polyclonal Antibody

Catalog Number: (CAPIPA5-18315)
Supplier: Thermo Scientific
Description: This antibody is predicted to react with mouse based on sequence homology. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms.
Product Image-14224-138

LABOPORT™ UN840 Vacuum Diaphragm Pumps, KNF

Supplier: KNF Neuberger Inc.
Description: Chemically resistant, oil-free diaphragm vacuum pump used for a wide range of laboratory applications. Especially suited for handling aggressive vapors, it features PTFE heads, PTFE-coated diaphragms and FFPM valves.

Product Image-26678-020

LABOPORT™ UN842 Vacuum Diaphragm Pumps, KNF

Supplier: KNF Neuberger Inc.
Description: Chemically resistant, oil-free diaphragm vacuum pump used for a wide range of laboratory applications. Especially suited for handling aggressive vapors, it features PTFE heads, PTFE-coated diaphragms and FFPM valves.

Image Unavailable-CAPIPA5-18759

Anti-COX4 Goat Polyclonal Antibody

Catalog Number: (CAPIPA5-18759)
Supplier: Thermo Scientific
Description: Cytochrome c oxidase is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 gene in a head-to-head orientation, and shares a promoter with it.
Product Image-46620-636

LABOPORT™ PowerDry™ Vacuum Diaphragm Pumps, Models UN820, UN840, UN842 and UN860, KNF

Supplier: KNF Neuberger Inc.
Description: Chemically resistant series of Laborport™ diaphragm vacuum pumps with the KNF PowerDry™ system that allows condensed liquids to be blown out of the pump heads at high speed during evacuation. These are best when moist gases must be pumped down such as when using a vacuum oven.

Product Image-14224-132

LABOPORT™ UN820 Vacuum Diaphragm Pump, KNF

Supplier: KNF Neuberger Inc.
Description: Chemically resistant, oil-free diaphragm vacuum pump used for a wide range of laboratory applications. Especially suited for handling aggressive vapors, it features PTFE heads, PTFE-coated diaphragms and FFPM valves.

Product Image-83007-682

pipetus®-standard and pipetus-junior Pipettors, Hirschmann

Supplier: Hirschmann
Description: The pipetus®-standard pipettor includes a separate 120V pump that allows the unit to be used with toxic liquids or under clean conditions because the air from the pump will not get into the working area.

Image Unavailable-CAAA44080-A3

Poly(vinylidene fluoride)

Supplier: Thermo Scientific Chemicals
Description: Poly(vinylidene fluoride) is useful in coatings, film, filter cloth, instrument linings, filtration membranes, pump parts, linings and valves. It is also employed as a material for transducers in devices such as headphones, microphones and sonic detectors. It is also essential for piezoelectric and electrostrictive applications. In addition, it is useful for monofilament fishing lines replacing nylon monofilament. It acts as a standard binder used in the production of composite electrodes for lithium ion batteries. It serves as a high grade insulator for wires, nanomaterials and pressure sensors. It is utilized to make filters which are used to prepare samples for high performance liquid chromatography and other advanced analytical techniques.
Notes: Incompatible with strong oxidizing agents.

Certificates

Image Unavailable-CA76409-106

Accessories for Vivapure® AdenoPACK Kits, Sartorius

Catalog Number: (CA76409-106)
Supplier: Sartorius
Description: Pump tubing set, for Vivapure Adenopack 100, Complete kit for fast purification of up to 1 x 10 raised to 13 adenovirus type 5 particles from 500 ml cell culture, Contains 2 AdenoPACK 100 syringe filter units with Sartobind ion exchange membrane plus all buffers
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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