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Catalog Number: (10487-046)
Supplier: Bioss
Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.


Supplier: Biolegend
Description: PerCP/Cy5.5 anti-mouse/rat/human CD27 [LG.3A10]; Isotype: Armenian Hamster IgG; Reactivity: Mouse, Rat, Human; Apps: FC; Size: 100 μg

Catalog Number: (CA143712-BL)
Supplier: Biolegend
Description: PerCP/Cy5.5 anti-mouse PD-1H (VISTA) [MH5A]; Isotype: Armenian Hamster IgG; Reactivity: Mouse; Apps: FC; Size: 100 μg


Catalog Number: (89286-106)
Supplier: Genetex
Description: Rat Monoclonal antibody to TCP1 alpha (t-complex protein 1) Clone: 23c Purity: Protein G purified Species Reactivity: Mouse Cow Dog Hamster Rabbit Rat Sheep Tested Applications: ICC/IF IP WB Pkg Size: 100 ug


Catalog Number: (ABCA_AB272251-100U)
Supplier: Abcam
Description: PerCP/Cy5.5® Rat monoclonal [OX-86] to CD134 / OX40L receptor.

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Catalog Number: (10667-448)
Supplier: Bioss
Description: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].


Catalog Number: (10412-066)
Supplier: Bioss
Description: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


Supplier: Biolegend
Description: PerCP/Cy5.5 anti-human CD158b (KIR2DL2/L3, NKAT2) [DX27]; Isotype: Mouse IgG2a, κ; Reactivity: Human; Apps: FC; Size: 100 tests

Supplier: Biolegend
Description: PerCP/Cy5.5 anti-mouse Ly-6A/E (Sca-1) [E13-161.7]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC; Size: 100 μg

Supplier: Biolegend
Description: PerCP/Cy5.5 Mouse IgG2b, κ Isotype Ctrl [MPC-11]; Isotype: Mouse IgG2b, κ; Reactivity: Mouse; Apps: FC, ICFC; Size: 100 tests

Supplier: Biolegend
Description: PerCP anti-mouse TER-119/Erythroid Cells [TER-119]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: FC; Size: 100 μg

Catalog Number: (76110-510)
Supplier: Bioss
Description: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.


Supplier: Biolegend
Description: PerCP/Cy5.5 anti-mouse CD3ε [145-2C11]; Isotype: Armenian Hamster IgG; Reactivity: Mouse; Apps: FC; Size: 100 μg

Supplier: Biolegend
Description: PerCP/Cy5.5 Mouse IgG1, κ Isotype Ctrl [MOPC-21]; Isotype: Mouse IgG1, κ; Reactivity: Mouse; Apps: FC, ICFC; Size: 100 tests

Supplier: Biolegend
Description: PerCP/Cy5.5 Mouse IgG2a, κ Isotype Ctrl [MOPC-173]; Isotype: Mouse IgG2a, κ; Reactivity: Mouse; Apps: FC, ICFC; Size: 100 μg

Catalog Number: (89416-168)
Supplier: Prosci
Description: TMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta; production, demonstrating that TMP21 can modulate gamma-secretase activity.


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