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Catalog Number: (10068-976)
Supplier: Prosci
Description: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.


Catalog Number: (10069-080)
Supplier: Prosci
Description: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.


Catalog Number: (CA89168-038)
Supplier: G-Biosciences
Description: Pepsin is a proteolytic enzyme that is routinely used for the generation of F(ab)<sub>2</sub> fragments from immunoglobulin G (IgG)

SDS


Catalog Number: (10068-924)
Supplier: Prosci
Description: Molecular chaperone. Has ATPase activity.


Catalog Number: (10068-500)
Supplier: Prosci
Description: Involved in stress resistance and actin organization.


Catalog Number: (10070-440)
Supplier: Prosci
Description: Plays an important role in the physiology of adrenergic neurons.


Catalog Number: (10075-384)
Supplier: Prosci
Description: There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (A and B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones. Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor. Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.


Catalog Number: (10075-676)
Supplier: Prosci
Description: Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 9 is the site on synapsin I that is phosphorylated by cAMP-dependent protein kinase and by calcium calmodulin kinase I. Phosphorylation of this site is thought to regulate synaptic vesicle function.


Supplier: CUBE BIOTECH
Description: PureCube StrepTactin® MagBeads are a suspension of 6% cross-linked magnetic agarose beads coupled to a StrepTactin protein.

Catalog Number: (10068-594)
Supplier: Prosci
Description: May play an important role in cell fate determination during lung development and in spermatogenesis


Catalog Number: (10075-394)
Supplier: Prosci
Description: Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAM K II). Both PKA and CAM K II phosphorylate Ser58 which lies within the regulatory domain of TPH.


Catalog Number: (10070-786)
Supplier: Prosci
Description: May play a role in germ cell development. May play a role in sperm motility.


Catalog Number: (10071-486)
Supplier: Prosci
Description: Binds to CNTF. The alpha subunit provides the receptor specificity.


Catalog Number: (10068-868)
Supplier: Prosci
Description: Molecular chaperone. Has ATPase activity.


Catalog Number: (10068-458)
Supplier: Prosci
Description: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors


Catalog Number: (10069-046)
Supplier: Prosci
Description: Probably involved in formation of autophagosomal vacuoles (autophagosomes).


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