You Searched For: Sulfo-SMA

Supplier: MilliporeSigma

Certificates

Catalog Number: (10094-886)

Supplier: Proteintech

Description: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by loss of anterior horn cells in the spinal cord and concomitant symmetrical muscle weakness and atrophy . SMA is caused by deletion or mutations of the survival motor neuron (SMN1) gene. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional . A large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein . The level of SMN protein correlates with phenotypic severity of SMA. This antibody, 60255-1-Ig, raised against the C-ternimal region (275-294aa) encoded by the exon 7, is secific to SMN1 (SMN-FL-specific), with no cross reaction with SMN2.

Supplier: Bachem Americas

Description: Sequence: ε-Maleimidocaproic acid-(2-nitro-4-sulfo)-phenyl ester · sodium salt
Synonym(s): mal-sac-HNSA

Catalog Number: (CA82022-796)

Supplier: G-Biosciences

Description: N-γ-Maleimidobutyryloxysulfosuccinimide ester Heterobifunctional Cross Linker.

Catalog Number: (ABCA_AB136481-30UL)

Supplier: Abcam

Description: Anti-Sulfotyrosine Mouse Monoclonal Antibody [clone: Sulfo-1C-A2]

New Product

Catalog Number: (76099-804)

Supplier: Bioss

Description: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

Supplier: New England Biolabs (NEB)

Description: An E. coli strain that carries the SmaI gene from Serratia marcescens (ATCC 49779).

Certificates

Catalog Number: (77392-562)

Supplier: CUBE BIOTECH

Description: Membrane proteins and their composition are as versatile as the whole cell membrane itself. For this reason, it is impossible to predict with 100% accuracy which SMALP product is best suited for the solubilization and subsequent preparation of your membrane protein of interest. We offer this SMALP Screening Kit that consists of our four individual SMAs. This way, you can conveniently screen for the best SMA for your protein before scaling up your assay. In case you would like to extend your polymer screening beyond the reaches of SMA, we offer our Synthetic Nanodisc Screening Kit, which covers both SMA and DIBMA.

Catalog Number: (TCS0128-001G)

Supplier: TCI America

Description: [Reagent for Aluminum]
CAS Number: 1563-01-5
MDL Number: MFCD00024960
Molecular Formula: C16H19N3O5S
Molecular Weight: 365.40
Form: Crystal
Color: Red

SDS

Catalog Number: (CAAAJ64508-03)

Supplier: Thermo Scientific Chemicals

Description: For iodination of proteins that do not contain tyrosine residues

Certificates

Supplier: Thermo Scientific

Description: Thermo Scientific Pierce BS3 (Sulfo-DSS) is bis(sulfosuccinimidyl)suberate, an amine-to-amine crosslinker that is homobifunctional, water-soluble, non-cleavable and membrane impermeable.

SDS Certificates

Catalog Number: (76099-802)

Supplier: Bioss

Description: Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially inactive at neutral pH but becomes active under acidic conditions such as during tumor invasion and in inflammatory processes. Facilitates cell migration associated with metastasis, wound healing and inflammation. Enhances shedding of syndecans, and increases endothelial invasion and angiogenesis in myelomas. Acts as procoagulant by increasing the generation of activation factor X in the presence of tissue factor and activation factor VII. Increases cell adhesion to the extacellular matrix (ECM), independent of its enzymatic activity. Induces AKT1/PKB phosphorylation via lipid rafts increasing cell mobility and invasion. Heparin increases this AKT1/PKB activation. Regulates osteogenesis. Enhances angiogenesis through up-regulation of SRC-mediated activation of VEGF. Implicated in hair follicle inner root sheath differentiation and hair homeostasis.

Catalog Number: (RC8113-4)

Supplier: Ricca Chemical

Description: Tropaeolin O 0.04% (w/v) in aqueous solution indicator

SDS Certificates

Catalog Number: (76709-662)

Supplier: AFG Bioscience

Description: Human α-Smooth Muscle Actin(α-SMA) ELISA Kit

Catalog Number: (CA1.04593.0025)

Supplier: MilliporeSigma

SDS Certificates

Catalog Number: (10081-518)

Supplier: Proteintech

Description: The survival of motor neurons (SMN) genes are the disease genes of spinal muscular atrophy (SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody 60154-1-Ig is specific to human SMN2. It can't recognize mouse and rat SMN.