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Product Image-470301-608

Luminol

Supplier: Ward's Science
Description: CAS Number: 521-31-3
Formula: C8H7N3O2
Density: Approximately 0.90—1.0 g/mL
Boiling Point: 300°C
Solubility: Alcohol and Water
Synonyms: 3-Aminophthalhydrazide
Shelf Life: 12 Months

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Product Image-470300-154

Aluminum Potassium Sulfate 12-Hydrate

Supplier: Ward's Science
Description: CAS Number: 7784-24-9
Formula: AlK(SO4)2·12H2O
Density: 1.97 g/mL
Freezing Point: Loses H2O at 93°C
Solubility: Water
Shelf Life: 36 Months

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Product Image-470024-814

Loading Dye

Catalog Number: (470024-814)
Supplier: Ward's Science
Description: Solution used for tracking DNA during agarose electrophoresis; prepared with ultra-pure water and reagent-grade chemicals. 10X concentration.

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Product Image-470302-390

Silver Nitrate

Supplier: Ward's Science
Description: CAS Number: 7761-88-8
Formula: AgNO3
Density: 4.35 g/mL
Freezing Point: 212 °C
Solubility: Water, Hot Alcohol
Shelf Life: 24 Months

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Product Image-470300-450

Bromothymol Blue

Supplier: Ward's Science
Description: CAS Number: 34722-90-2
Formula: C27H27Br2O5SNa
Boiling Point: Decomposes
Solubility: Water
Synonyms: Bromothymol Blue pH Indicator
Shelf Life: 36 Months

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Product Image-10451-498

Anti-XPC Rabbit Polyclonal Antibody

Catalog Number: (10451-498)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Image Unavailable-76118-502

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76118-502)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Image Unavailable-76118-500

Anti-XPC Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76118-500)
Supplier: Bioss
Description: Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
Product Image-470300-262

Ammonium Thiocyanate

Supplier: Ward's Science
Description: CAS Number: 1762-95-4
Formula: NH4SCN
Density: 1.3 g/mL
Freezing Point: Approximately 149°C
Solubility: Water, Alcohol, Acetone, and Ammonia
Synonyms: Thiocyanic Acid Ammonium Salt
Shelf Life: 12 Months

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Product Image-470300-328

Barium Hydroxide Octahydrate

Supplier: Ward's Science
Description: CAS Number: 12230-71-6
Formula Weight: 315.48
Formula: BaOH2·8H2O
Density: 2.18 gg/mL
Solubility: Water, Alcohol and Ether
Synonyms: Barium Hydrate, Barium Octahydrate
Shelf Life: 12 Months

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Product Image-470301-620

Magnesium Bromide Hexahydrate

Supplier: Ward's Science
Description: CAS Number: 13446-53-2
Formula Weight: 292.25
Formula: MgBr2·6H2O
Synonyms: Magnesium Bromide 6-Hydrate
Shelf Life (months): 12
Storage: Green

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Product Image-470301-898

n-Propyl Alcohol

Supplier: Ward's Science
Description: CAS Number: 71-23-8
Formula: CH3CH2CH2OH
Density: 0.8044 g/mL
Boiling and Freezing Point: 97.8°C, -127°C
Solubility: Water and Alcohol
Synonyms: 1-Propanol
Shelf Life: 24 Months

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Product Image-470302-860

Sulfuric Acid

Supplier: Ward's Science
Description: CAS Number: 7664-93-9
Formula: H2SO4
Density: 1.84 g/mL
Boiling and Freezing Point: 275-325°C, 11°C
Solubility: Water
Synonyms: Hydrogen Sulfate, Battery Acid
Shelf Life: 12 Months

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Product Image-470302-198

Potassium Nitrate

Supplier: Ward's Science
Description: CAS Number: 7757-79-1
Formula: KNO3
Density: 2.1 g/mL
Boiling and Freezing Point: 400°C, 333°C
Solubility: Water, Glycerin, and Alcohol
Synonyms: Potash Nitrate, Saltpeter
Shelf Life: 36 Months

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Product Image-470300-546

Calcium Carbonate

Supplier: Ward's Science
Description: CAS Number: 1317-65-3
Formula: CaCO3
Density: 2.71 g/mL
Solubility: Water and Acids
Synonyms: Precipitated Chalk, Natural Chalk, Powdered Chalk
Shelf Life: 36 Months
Storage: Green

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Product Image-470301-142

D-Glucose Anhydrous

Supplier: Ward's Science
Description: CAS Number: 50-99-7
Formula: C6H12O6
Density: 1.5 g/mL
Freezing Point: 148 °C
Solubility: Water
Synonyms: Dextrose
Shelf Life: 12 Months

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