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Image Unavailable-CA76634-486

Anti-TNF-alpha Mouse Monoclonal Antibody [clone: LL025]

Catalog Number: (CA76634-486)
Supplier: Diagnostic Biosystems
Description: This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-α (Tumor Necrosis Factor-alpha). Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kDa and can be expressed as a free molecule, also TNF-α is generated as a precursor form called transmembrane TNF-α can be expressed as a cell surface type II polypeptide consisting of 233 amino acid residues molecular weight 26 kDa. TNF-α is an important cell-signaling component of the immune system. It is a protein secreted by LPS stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF-α is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Image Unavailable-CA76633-894

Anti-MLH-1 Mouse Monoclonal Antibody [clone: G168-15]

Supplier: Diagnostic Biosystems
Description: The G168-15 antibody recognizes human and mouse MLH1 (80 to 85 kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Image Unavailable-CA76634-536

Anti-Glypican-3 Mouse Monoclonal Antibody [clone: YP7]

Catalog Number: (CA76634-536)
Supplier: Diagnostic Biosystems
Description: Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms' tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilms' tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that offollicular adenoma.
Product Image-10809-908

Blueing reagent working solution, Pureview PH-Blue (pH 8)

Catalog Number: (10809-908)
Supplier: CANCER DIAGNOSTICS, INC.
Description: The Endure Staining System is designed to produce precise, consistent H&E staining.

SDS


Image Unavailable-CA76634-534

Anti-Fascin-1 Mouse Monoclonal Antibody [clone: 55k-2]

Catalog Number: (CA76634-534)
Supplier: Diagnostic Biosystems
Description: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.
Image Unavailable-CA76634-114

Anti-Fascin-1 Mouse Monoclonal Antibody [clone: 55k-2]

Supplier: Diagnostic Biosystems
Description: Recognizes a protein of 55 kDa, which is identified as fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin s disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

Product Image-470183-256

Skin Cancer Slide

Catalog Number: (470183-256)
Supplier: Avantor
Description: Demonstrates diseased epidermis
Product Image-470190-712

Ward's® Detection of Hereditary Breast Cancer Kit

Catalog Number: (470190-712)
Supplier: Avantor
Description: Can cancer be inherited?
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Acute Granulocytic Leukemia

Catalog Number: (470183-238)
Supplier: Avantor
Description: Blood cancer.
Product Image-77750-342

Human Recombinant MIP-4 (from E. coli)

Supplier: VWR International
Description: Macrophage inflammatory protein-4 (MIP-4), also called CCL18, is a chemokine expressed in the lymph nodes, lungs, placenta, and bone marrow. MIP-4 receptors include the chemokine receptor 8 (CCR8), the G protein-coupled receptor 30 (GPR30), and the phosphatidylinositol transfer protein membrane-associate 3 (PITPNM3). MIP-4 acts as a chemoattractant for naive T cells, CD4+ T cells, CD8+ T cells, and nonactivated lymphocytes. Further, MIP-4 promotes breast cancer metastasis and attenuates the activation of acute lymphocytic leukemia B cells.

New Product

Product Image-470126-658

In Search of the Cancer Gene

Catalog Number: (470126-658)
Supplier: Edvotek
Description: Determine Genetic Predisposition for Cancer
Product Image-470024-510

Blood Based Cancer Diagnosis Lab Activity

Catalog Number: (470024-510)
Supplier: Edvotek
Description: Cancer cells differ from normal cells by the combination of normal proteins that are present on their surfaces.
Product Image-61161-321

VWR® Humidity Sponges, Desiccator in a Bag

Supplier: VWR International
Description: Humidity sponges turn any container into a desiccator and are ideal for storing samples, food, pharmaceuticals, electronics, PC boards, optics, diagnostics, museum pieces, chemicals, instruments, and documents.

SDS Certificates

Product Image-76711-870

Rat Ovarian Cancer Marker 125 (CA125) ELISA Kit

Catalog Number: (76711-870)
Supplier: AFG Bioscience
Description: Rat Ovarian Cancer Marker 125 (CA125) ELISA Kit
Product Image-77750-818

Human Recombinant FGF-10 (from E. coli)

Supplier: VWR International
Description: <p>Fibroblast growth factor 10 (FGF-10) is a growth factor that is important during embryonic development, especially during lung, limb, brain, heart, and kidney morphogenesis. FGF-10 is expressed in mesenchymal cells and facilitates epithelial-mesenchymal signaling through binding the epithelially expressed FGF receptor 2b (FGFR2b). FGF-10 also functions as a mitogen for keratinizing epidermal cells, and induces the migration and invasion of cancer cells.</p>

New Product

Image Unavailable-76118-664

Anti-Cancer testis antigen 65 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76118-664)
Supplier: Bioss
Description: TULP2 is a member of a family of tubby-like (TULP) proteins which share a conserved C terminal region of approximately 200 amino acid residues. It is strongly expressed in testis and is expressed in the retina. It is also expressed in cancer cell lines.
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