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Image Unavailable-10389-014

Anti-PRR5 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10389-014)
Supplier: Bioss
Description: Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
Product Image-10095-472

Anti-BIRC5 Rabbit Polyclonal Antibody

Catalog Number: (10095-472)
Supplier: Proteintech
Description: Survivin, also called BIRC5, is a unique member of the inhibitor of apoptosis (IAP) protein family. Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy, but is completely absent in terminally differentiated cells. The differential expression of survivin in cancer versus normal tissues makes it a useful tool in cancer diagnosis and a promising therapeutic target. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. Disruption of survivin-microtubule interactions results in loss of survivin's anti-apoptosis function and increased caspase-3 activity, a mechanism involved in cell death, during mitosis. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.
Image Unavailable-CAPIPA5-18888

Anti-NRAS Goat Polyclonal Antibody

Catalog Number: (CAPIPA5-18888)
Supplier: Thermo Scientific
Description: This antibody is predicted to react with canine and mouse based on sequence homology. This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.
Image Unavailable-76107-222

Anti-CT74 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76107-222)
Supplier: Bioss
Description: CCDC36 , also known as CT74 (cancer/testis antigen 74), is a 584 amino acid protein that contains coiled-coil domains and is expressed as three alternatively spliced isoforms. The gene encoding CCDC36 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
Product Image-76262-634

Anti-HER2 Recombinant Monoclonal Antibody

Catalog Number: (76262-634)
Supplier: Rockland Immunochemical
Description: HER2 (human epidermal growth factor receptor 2) is a member of the epidermal growth factor receptor (HER/EGFR/ERBB) family. It is also called ERBB2, CD340 or proto-oncogene Neu. The protein is a receptor tyrosine kinase located on the plasma membrane of cells. Activation of the tyrosine kinase promotes cell proliferation and suppresses apoptosis. HER2 can dimerize with any other member of the ErbB family, which results in auto phosphorylation of tyrosine residues and activation of signal pathways. HER2 is over expressed in a significant proportion of cancer patients, resulting in an increased disease recurrence and poor prognosis. Therefore an early diagnosis of the HER2 status of the tumors is necessary to decide the appropriate treatment. Besides in breast cancer HER2 is over expressed in variety of different tumors. The over expression of HER2 makes it a target for immunotherapy of certain tumor patients. The antibody Trastuzumab (Herceptin) which recognizes HER2 was approved for the treatment of HER2 positive breast cancer patients in 1998. The original approval was for treatment of HER2 positive metastatic breast tumors. Later studies have shown that Herceptin is also beneficial for early stage HER2 positive tumor patients and it is approved as an adjuvant treatment. Additionally the antibody is now approved also for other HER2 positive tumors (metastatic gastric adenocarcinoma). This antibody is made from a humanized Fab fragment making it specific, efficient, and effective. Humanized Recombinant Anti-HER2 Fab fragment Antibody is useful for researchers interested in Cancer research.
Product Image-10198-596

Head Mirror, Sklar

Supplier: Sklar
Description: The Head Mirror is used in conjunction with a headband (sold seperately) as a diagnostic tool, often as part of an ENT examination

Product Image-10103-100

Anti-RRP1B Rabbit Polyclonal Antibody

Catalog Number: (10103-100)
Supplier: Prosci
Description: RRP1B belongs to the RRP1 family. It may be a novel susceptibility gene for breast cancer progression and metastasis.
Product Image-10147-016

Accessories for hema-screen™, Immunostics

Catalog Number: (10147-016)
Supplier: IMMUNOSTICS, INC.
Description: Hema-screen ER XCEL*Developer, Contains 8 X 10ml Bottles FOBT Developer, one Product Insert

SDS


Product Image-10093-652

Anti-RHOC Rabbit Polyclonal Antibody

Catalog Number: (10093-652)
Supplier: Proteintech
Description: Ras homolog family member C (RHOC) encodes a Rho-related GTP-binding protein, which belongs to small GTPase superfamily and also Rho family. RHOC. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Expression of RHOC contributes to metastatic phenotype of melanoma cells and is associated with multiple cancers including gastric carcinomas, ovarian carcinomas and breast cancer as well.
Image Unavailable-10388-000

Anti-SCGB2A1 Rabbit Polyclonal Antibody

Catalog Number: (10388-000)
Supplier: Bioss
Description: Mammaglobin B may bind androgens and other steroids, it may also bind estramustine, a chemotherapeutic agent used for prostate cancer. It may be under transcriptional regulation of steroid hormones.
Image Unavailable-10591-374

Accessories for ThunderBolt® Immunoassay Platform, Gold Standard Diagnostics

Supplier: Gold Standard Diagnostics

Product Image-10107-496

Anti-KDM4D Rabbit Polyclonal Antibody

Catalog Number: (10107-496)
Supplier: Prosci
Description: JMJD2D belongs to JMJD2 family that is consist of four cancer-associated genes
Product Image-11217-086

Infecon® 6000 Infectious Substance Shipper, Com-Pac

Catalog Number: (11217-086)
Supplier: Com-Pac
Description: Perfect overpack insulated container for shipping infectious substances or diagnostic specimens which must be kept frozen or refrigerated.
Product Image-CA89426-250

MacConkey Broth, Hardy Diagnostics

Supplier: HARDY DIAGNOSTICS CA
Description: MacConkey Broth available with or without Durham Tube, optically clear, shatter resistant, polycarbonate tube, order by the package of 20, by Hardy Diagnostics.

Certificates

Image Unavailable-89274-088

Anti-CTAG1B (cancer/testis Antigen 1B) Mouse Monoclonal Antibody [clone: 3F10]

Catalog Number: (89274-088)
Supplier: Genetex
Description: Mouse monoclonal antibody [3F10] to CTAG1B
Image Unavailable-10349-232

Anti-HPV33 E6 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10349-232)
Supplier: Bioss
Description: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. The E6 protein is a transcriptional transactivator. Binds double-stranded DNA. This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus).
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