You Searched For: PD+98059

Supplier: Diagnostic Biosystems

Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

Catalog Number: (103294-276)

Supplier: Novus Biologicals

Description: The VISTA / B7-H5 / PD-1H Antibody (855328) [DyLight 755] from Novus Biologicals is a mouse monoclonal antibody to VISTA / B7-H5 / PD-1H. This antibody reacts with human. The VISTA / B7-H5 / PD-1H Antibody (855328) [DyLight 755] has been validated for the following applications: Flow Cytometry.

Catalog Number: (75794-280)

Supplier: Prosci

Description: T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumor cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.

Supplier: Thermo Scientific Chemicals

Description: MDL: MFCD00011171

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Supplier: TCI America

Description: CAS Number: 12135-22-7 Molecular Formula: H2O2Pd Molecular Weight: 140.43 Form: Crystals Color: Black Flash Point (°C): 180

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Catalog Number: (76163-666)

Supplier: Prosci

Description: PD-L1 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC) (1). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC (2). PD-1 can bind two different but related ligands, PD-L1 and PD-L2. PD-L1 is a B7-related protein that inhibits cell-mediated immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells (3). This suggests that PD-L1 may be useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host immune responses to allografts. PD-L1 also functions as an immune checkpoint protein, and multiple anti-PD-L1 antibodies are currently in phase II and III clinical trials, with one antibody already approved for the treatment of cancer (4).

Catalog Number: (77174-238)

Supplier: ANTIBODIES.COM LLC

Description: Mouse PD-L1 ELISA kit is a 90 minutes sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the <i>in vitro</i> quantitative determination of mouse PD-L1 in serum, plasma, and other biological fluids.

Catalog Number: (103294-704)

Supplier: Novus Biologicals

Description: The PD-1 Antibody (913425) [FITC] from Novus Biologicals is a mouse monoclonal antibody to PD-1. This antibody reacts with human. The PD-1 Antibody (913425) [FITC] has been validated for the following applications: Flow Cytometry.

Supplier: ANTIBODIES.COM LLC

Description: Recombinant Human PD-L1 (from HEK293 cells)

Catalog Number: (ABCA_AB210189-100U)

Supplier: Abcam

Description: Anti-PD-L1 Rat Monoclonal Antibody [clone: 10F.9G2] (PE)

New Product

Catalog Number: (CAAA46383-03)

Supplier: Thermo Scientific Chemicals

Description: Dichloro[1,1'-bis(dicyclohexylphosphino)ferrocene]palladium(II), Pd 14.1%

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Catalog Number: (77119-342)

Supplier: Prosci

Description: Rat Recombinant PD-1 Protein (from HEK293 Cells)

Catalog Number: (77122-010)

Supplier: Prosci

Description: Mouse Recombinant PD-1 Protein (from HEK293 Cells)

Catalog Number: (10797-762)

Supplier: Prosci

Description: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-?. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-? by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-? secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.

Catalog Number: (76949-244)

Supplier: ANTIBODIES.COM LLC

Description: Mouse monoclonal [PDL1/2746] antibody to PD-L1 (PE) for Flow Cytometry and IF with samples derived from Human and Mouse.

Supplier: Thermo Scientific Chemicals

Description: Bis[1,2-bis(diphenylphosphino)ethane]palladium(0)

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