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Image Unavailable-76083-068

Anti-TNFR1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76083-068)
Supplier: Bioss
Description: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Image Unavailable-CAMB-114-0001

Staphylococcus aureus V8 Protease

Catalog Number: (CAMB-114-0001)
Supplier: Rockland Immunochemical
Description: All enzymes and related reagents are configured as an integrated system and have been thoroughly tested.

SDS


Image Unavailable-103007-212

Human [Gln22, Asn23]-beta-Amyloid (1-40)

Catalog Number: (103007-212)
Supplier: Anaspec Inc
Description: This peptide is the mutant form of beta-Amyloid 1 to 40. These mutations within the beta-Amyloid precursor protein (APP) regions result in the substitution of glutamine for glutamic acid and asparagine for aspartic acid. The peptide rapidly assembles in solution to form fibrils compared to the wild-type beta-Amyloid 1 to 40. Double-mutant E22Q/D23N Dutch/Iowa beta-Amyloid 40 is more potent than either of the single mutant form in causing pathologic responses in culture cells. The double mutations further enhances the fibrillogenic and pathogenic properties of beta-Amyloid.
Sequence: DAEFRHDSGYEVHHQKLVFFAQNVGSNKGAIIGLMVGGVV
Molecular Weight: 4327.9 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C
Image Unavailable-CA80058-432

MOPS-Na, ULTROL®

Catalog Number: (CA80058-432)
Supplier: MilliporeSigma
Description: MOPS-Na, ULTROL®

SDS Certificates


Product Image-10075-662

Anti-GRIA1 Rabbit Polyclonal Antibody

Catalog Number: (10075-662)
Supplier: Prosci
Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of 4 distinct subunits (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is also potentiated by phosphorylation at Ser845. In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory.
Image Unavailable-76234-810

Anti-TNFR-I Rabbit Polyclonal Antibody

Catalog Number: (76234-810)
Supplier: Rockland Immunochemical
Description: Tumor necrosis factor receptor superfamily member 1A (TNF p55 Receptor) is a receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. It contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Image Unavailable-CAAAA17214-22

MOPS-Na 98%

Supplier: Thermo Scientific Chemicals
Description: MOPS-Na 98%

Certificates

Product Image-10749-370

Anti-BACE Rabbit Polyclonal Antibody

Catalog Number: (10749-370)
Supplier: Prosci
Description: BACE Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.
Product Image-10749-368

Anti-BACE2 Rabbit Polyclonal Antibody

Catalog Number: (10749-368)
Supplier: Prosci
Description: BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.
Product Image-10750-584

Anti-HAAO Rabbit Polyclonal Antibody

Catalog Number: (10750-584)
Supplier: Prosci
Description: HAAO Antibody: HAAO (3-Hydroxyanthranilate 3, 4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.
Product Image-10075-660

Anti-GRIA1 Rabbit Polyclonal Antibody

Catalog Number: (10075-660)
Supplier: Prosci
Description: The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by beta-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct subunits GluR1-4 and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is also potentiated by phosphorylation at Ser831. In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory.
Image Unavailable-TCG0121-001G

Glycyl-L-aspartic acid monohydrate

Catalog Number: (TCG0121-001G)
Supplier: TCI America
Description: CAS Number: 4685-12-5
MDL Number: MFCD00025585
Molecular Formula: C6H10N2O5
Molecular Weight: 190.16
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Specific rotation [a]20/D: 13 deg (C=2, H2O)

SDS


Image Unavailable-TCM0606-025G

β-(N-Morpholino)ethanesulfonic acid (MES) ≥99.0% (by titrimetric analysis)

Supplier: TCI America
Description: CAS Number: 4432-31-9
MDL Number: MFCD00006181
Molecular Formula: C6H13NO4S
Molecular Weight: 195.23
Purity/Analysis Method: >99.0% (T)
Form: Crystal
Melting point (°C): 316

SDS Certificates

Product Image-10078-840

Anti-GOT1 Sheep Polyclonal Antibody

Catalog Number: (10078-840)
Supplier: Prosci
Description: Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology.
Image Unavailable-CA80058-420

β-(N-Morpholino)ethanesulfonic acid (MES) ≥99% (by titrimetric analysis on dry substance), ULTROL®, Calbiochem®

Supplier: MilliporeSigma
Description: A zwitterionic buffer useful in the pH range of 5.5 to 6.5, has a pKa of 6.10 at 25 °C.

SDS Certificates

Image Unavailable-10084-084

Anti-CASP12 Rabbit Polyclonal Antibody

Catalog Number: (10084-084)
Supplier: Proteintech
Description: Caspase 12 is an enzyme known as a cysteine protease. It belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. It is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. Caspase-12 is located in the endoplasmic reticulum (ER). It is responsible for ER-stress-induced apoptosis, such as high calcium concentration, low oxygen and low glucose levels. Caspase-12 Antibody detects endogenous levels of full-length caspase-12 protein (50 kDa) and its cleaved product (40-44 kDa). This antibody does not cross-react with other caspases.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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