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Catalog Number: (10461-956)
Supplier: Bioss
Description: G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.


Catalog Number: (10404-030)
Supplier: Bioss
Description: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.


Catalog Number: (10404-014)
Supplier: Bioss
Description: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.


Supplier: VWR International
Description: For small to medium capacity applications, the CC series offers traditional canister-style cryogenic storage in efficient narrow neck designs.

Small Business Enterprise Product available on GSA Advantage®

Supplier: Biotium
Description: This antibody reacts with tissue non-specific alkaline phosphatase. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Catalog Number: (75834-782)
Supplier: Restek
Description: SAE30 motor oil:SAE40 motor oil (1:1).


Catalog Number: (100495-300)
Supplier: Electron Microscopy Sciences
Description: MAC has developed multi-element blocks of reference materials suitable for the compilation of a reference library of Auger sensitivity factors when used with the Auger Electron Microscopy (AES). (Auger electron: one of the electrons ejected from an atom as a result of the internal conversion of its own X-ray in the auger effect. Auger effect: a process in which an atom singly ionized by emitting one electron with energy in the X-ray range instead of emitting the usual X-ray photon on recovery undergoes a transition in which a second electron is emitted).

Minority or Woman-Owned Business Enterprise


Supplier: Heathrow Scientific
Description: Oil free boats for general-purpose weighing, dispensing, storage, food processing, evaporating or drying.

New Product

Catalog Number: (470178-434)
Supplier: Ward's Science
Description: Use this solution to clean immersion oil off microscope objectives.

SDS


Supplier: Electron Microscopy Sciences
Description: Residual Oil Remover is designed to emulsify and remove microscopic oil residues a by-product of environmental pollution from the surface and pores of glass and plastic.

Supplier: Thermo Scientific Chemicals
Description: Catalyst precursor
Supplier: VWR International
Description: The VWR® Autoclaves are ideal for sterilization of media, liquid, glassware, plasticware and other common research laboratory items. Available in 8, 18, 23 and 28 L chamber volumes, the range meets small to medium size applications in a space saving benchtop design.

Supplier: VWR International
Description: Combining the convenience of box vial storage with the economy of a low nitrogen loss design, the BR Series provides the perfect solution for medium to large storage needs.

Small Business Enterprise Product available on GSA Advantage®

Supplier: VWR International
Description: Versatile, general purpose, low-polarity phase for a wide range of applications, including (for example): PCBs, essential oils, pesticides, semivolatiles and many more. HI-5 is a crossbonded phase and assure a long lifetime even under high temperature limits.
Catalog Number: (16455-000)
Supplier: Qorpak
Description: Clear/flint oil sample bottles are provided with a #6 cork and feature a unique design.

Small Business Enterprise


Supplier: VWR International
Description: Sharps container systems provide solutions for the safe and effective containment and disposal of contaminated needles, syringes, and other sharps.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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