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Product Image-89416-924

Anti-LRFN2 Rabbit Polyclonal Antibody

Catalog Number: (89416-924)
Supplier: Prosci
Description: LRFN2 Antibody: LRFN2 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system.
Image Unavailable-10352-100

Anti-BTK Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10352-100)
Supplier: Bioss
Description: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.
Image Unavailable-CAG1600-62211

Standard Bare Fused Silica Capillaries, Agilent Technologies

Catalog Number: (CAG1600-62211)
Supplier: AGILENT TECHNOLOGIES, INC (CSD) CA
Description: Pre-aligned fused-silica capillaries from Agilent Technologies are designed and optimised for ease of use and reliability. All capillary ends are cut to a smooth, mirror-like finish. In addition, the polyimide outer coating is removed from the ends. These processes ensure minimal sample adsorption and help maintain sharp peak shapes. All capillaries have a pre-made detection 'window' and a built-in alignment stopper that allows rapid and precise insertion in the alignment interface.
Image Unavailable-CA95043-574

Protein Solubilization Buffer, G-Biosciences

Catalog Number: (CA95043-574)
Supplier: G-Biosciences
Description: G-Biosciences' FOCUS™ Protein Solubilization Buffer is a dry, urea-based and ready-to-use buffer for protein solubilization

SDS


Image Unavailable-CAAAJ64753-MA

EX 527

Catalog Number: (CAAAJ64753-MA)
Supplier: Thermo Scientific Chemicals
Description: A potent and selective inhibitor of the SIRT1 class III histone deacetylase enzyme

Certificates


Product Image-76533-624

Sentinel XL® OV/AG Cartridge Filters, ILC Dover

Catalog Number: (76533-624)
Supplier: ILC DOVER LP
Description: The OV/AG cartridge filters protect against particulates, organic vapors, chlorine, hydrogen chloride, sulfur dioxide, chlorine dioxide, and hydrogen fluoride.
Image Unavailable-H-4320.0250BA

H-Met-Arg-Phe-Ala-OH

Supplier: Bachem Americas
Description: MRFA is used as a calibration standard in mass spectrometry (ESI). Miao et al. studied Pt(II) complexes of the tetrapeptide by mass spectrometric methods. MRFA has been shown to be a competitive inhibitor of an enkephalin-generating endopeptidase isolated from rat brain. The peptide is a substrate for dipeptidyl peptidase III from human erythrocytes and for snapalysin.

Image Unavailable-10485-120

Anti-FNDC1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10485-120)
Supplier: Bioss
Description: FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G∫ and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events.
Image Unavailable-76108-750

Anti-FNDC1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76108-750)
Supplier: Bioss
Description: FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events.
Product Image-47750-038

SP Bel-Art Three-Way Fluoroplastic Stopcocks, Bel-Art Products, a part of SP

Catalog Number: (47750-038)
Supplier: Bel-Art Products, a Part of SP
Description: The three-way configuration of these stopcocks permits connection of any two or all three ports.

Certificates


Image Unavailable-10485-114

Anti-FNDC1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10485-114)
Supplier: Bioss
Description: FNDC1, also known as MEL4B3, Ags8, Expressed in synovial lining protein and Activation-associated cDNA protein, is a 1888 amino acid secreted protein that contains five fibronectin type-III domains. FNDC1 is moderately expressed in skeletal muscle, pancreas, heart, kidney, spinal cord, ovary and lung. Expression of FNDC1 is induced in response to hypoxia in ventricular cardiomyocytes. Since FNDC1 interacts with G∫ and G©, it is likely that FNDC1 is an activator for G-protein signaling. Though normally absent in healthy skin, FNDC1 expression is induced by TGF-beta signaling in skin tumors and psoriasis. There are two isoforms of FNDC1 that are produced as a result of alternative splicing events.
Image Unavailable-CAAAB22490-30

Magnesium silicate 60-120 mesh for chromatography

Supplier: Thermo Scientific Chemicals
Description: Magnesium silicate, activated, is used in polyether adsorption and decolorization effect. Also used in chromatography.
Notes: Incompatible with strong acids and hydrogen fluoride.

Certificates

Product Image-89401-370

Low Form Zirconium Crucibles

Supplier: XRF Scientific
Description: Zirconium's distinctive properties make it a popular choice for fusions and fluxes in analytical chemistry and chemical processing.

Image Unavailable-75791-818

Human Recombinant Irisin (from Cells)

Catalog Number: (75791-818)
Supplier: Prosci
Description: FNDC5 is a membrane protein comprised by a short cytoplasmic domain, a transmembrane segment, and an ectodomain consisting of a fibronectin type III (FNIII) domain. The ectodomain has been proposed to be cleaved to a soluble peptide hormone named “irisin”. Irisin is secreted from muscle in response to exercise, and may regulate energy metabolism, stem cell differentiation, and neuronal development. The circulating irisin converts white fat into the more thermogenic beige fat, and may mediate some beneficial effects of exercise in humans and the potential for generating weight loss. In mice, expression of Irisin has been shown to regulate obesity and diabetes. A similar function is suggested in human.
Product Image-89093-952

VWR® TraceClean® Wide Mouth Jars, Glass

Supplier: VWR International
Description: Type III (soda-lime) jars are for collection of solid matrices or liquids dispensed from bailers or peristaltic tubing.

Small Business Enterprise

Image Unavailable-76116-370

Anti-ITPR3 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76116-370)
Supplier: Bioss
Description: Inositol 1,4,5-triphosphate (IP3) functions as a second messenger for a myriad of extracellular stimuli including hormones, growth factors and neurotransmitters. Receptor tyrosine kinases indirectly increase the intracellular levels of IP3 through the activation of phospholipases such as phospholipase C (PLC), which convert phosphatidylinositol-4,5 bisphosphate into IP3 and diacylglycerol (DAG). The inositol 1,4,5-triphosphate receptor, IP3R, acts as an inositol triphosphate (IP3)-gated calcium release channel in a variety of cell types. Three IP3 receptor subtypes have been described and are designated IP3R-I, IP3R-II and IP3R-III. IP3R-I is the predominant IP3R subtype expressed in neuronal tissues and the central nervous system, but is also expressed at high levels in the liver.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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