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Image Unavailable-76099-502

Anti-ATF4/CREB-2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76099-502)
Supplier: Bioss
Description: Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.
Image Unavailable-CA76633-464

Anti-Alpha Actinin Mouse Monoclonal Antibody [clone: EA-53]

Supplier: Diagnostic Biosystems
Description: This antibody is specific for α-skeletal muscle actinin and α-cardiac actinin. It stains Z lines and dots in stress fibers of myotubes in skeletal and cardiac muscle but not in non-sarcomeric muscle elements.

Image Unavailable-10401-414

Anti-PP2CA Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10401-414)
Supplier: Bioss
Description: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
Product Image-80070-714

Funnels, Addition, Graduated, PTFE Metering Stopcocks, Chemglass

Supplier: Chemglass
Description: Cylindrical style addition funnels feature a PTFE adjustable bore metering plug.

Small Business Enterprise

Image Unavailable-76081-334

Anti-GADD45B Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76081-334)
Supplier: Bioss
Description: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
Product Image-10749-924

Anti-IER3 Rabbit Polyclonal Antibody

Catalog Number: (10749-924)
Supplier: Prosci
Description: IEX-1 Antibody: IEX-1 is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-alpha. IEX-1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. It plays an important role in the regulation of cellular growth, cell death and oncogenesis. IEX-1 is precisely regulated by multiple transcription factors such as p53, NF-kappa B/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX-1 in cells under a variety of stress conditions. IEX-1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX-1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX-1 expression is associated with decreases in both apoptosis and cell cycle progression.
Product Image-470106-452

Plastic Four-Sided Meter Stick

Catalog Number: (470106-452)
Supplier: SI Manufacturing
Description: Four meter sticks in one and made of flexible plastic.
Product Image-60941-074

VWR® Adhesive PCR Foil Seals

Supplier: VWR International
Description: These soft, non permeable 63.5 µm thick aluminium foils, with strong medical grade adhesive, eliminate the need for heat sealing devices or mats during thermal cycling.

Certificates Product available on GSA Advantage®

Image Unavailable-10342-250

Anti-JNK1 / JNK2 / JNK3 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10342-250)
Supplier: Bioss
Description: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
Image Unavailable-10342-218

Anti-JNK1 / JNK2 / JNK3 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10342-218)
Supplier: Bioss
Description: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
Product Image-74950-334

Accessories for SP Bel-Art Riteflow® Panel/Bench Mounted Flowmeters, Bel-Art Products, a part of SP

Catalog Number: (74950-334)
Supplier: Bel-Art Products, a Part of SP
Description: Housed in black anodized aluminum frame with tube-lock to prevent turning during locking. Metering tube won’t shift under pressure or vacuum. With Buna-N, 316 stainless steel and Delrin* valves with hose barbs for 8 to 9.5mm I.D. tubing, removable for female 3.2mm NPT fittings.
Image Unavailable-10342-360

Anti-JNK1 / JNK2 / JNK3 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10342-360)
Supplier: Bioss
Description: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
Product Image-CA89508-364

Pocket Pro Tester, Conductivity, Low Range, Hach

Catalog Number: (CA89508-364)
Supplier: Hach
Description: Hach Pocket Pro and Pro+ are engineered to deliver accurate results. Calibration functions for ongoing testing, diagnostics with select models and a stabilized sample lock ensure you get the right reading. You also get replaceable batteries for convenient field use, and a large, easy-to-read LCD screen.
Product Image-470002-836

Folding Meter Stick

Catalog Number: (470002-836)
Supplier: Skywill Far East Industries
Description: This plastic meter stick folds into fourths on three hinges.
Product Image-10400-218

Anti-MMP2 Rabbit Polyclonal Antibody

Catalog Number: (10400-218)
Supplier: Bioss
Description: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
Product Image-75840-014

VWR® Advanced Melting Point Apparatus

Supplier: VWR International
Description: The VWR® Advanced Melting Point Apparatus is used in determining the purity of a sample and is optimized to quickly and efficiently heat up to 3 samples at one time.

Environmentally Preferable Product available on GSA Advantage®

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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