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Catalog Number: (10402-578)
Supplier: Bioss
Description: A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints and CHFR is one such protein. It has a FHA and ring finger domain within its N terminus. Within its C terminus, CHFR contains a cysteine-rich region that did not display significant similarity to any protein in the GenBank database, but is highly conserved between humans and mice. It has been concluded that CHFR defines a checkpoint that delays entry into metaphase in response to mitotic stress. It has been found CpG methylation-dependent silencing of CHFR expression occurs in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.


Catalog Number: (10068-500)
Supplier: Prosci
Description: Involved in stress resistance and actin organization.


Supplier: Glas-Col
Description: Precise heat control for small flasks.

Small Business Enterprise

Catalog Number: (60005-126)
Supplier: Kemtech America
Description: Replacement Teflon® metering stopcock.

Small Business Enterprise Minority or Woman-Owned Business Enterprise


Catalog Number: (10110-086)
Supplier: Prosci
Description: The function of GADD45B is involved in the regulation of growth and apoptosis.This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.


Supplier: EQUIP SOLUTIONS
Description: Optimize performance of your Pulsafeeder Solenoid Metering Pump.

Catalog Number: (75790-392)
Supplier: Prosci
Description: Mesencephalic astrocyte-derived neurotrophic factor(MANF) is a secreted protein which belongs to the ARMET family. MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues.


Supplier: Sper Scientific
Description: Ideal for testing for OSHA requirements.

Catalog Number: (10353-270)
Supplier: Bioss
Description: GCN2 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 to downregulate protein synthesis in response to varied cellular stresses.


Catalog Number: (10393-372)
Supplier: Bioss
Description: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.


Supplier: Enzo Life Sciences
Description: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor, which regulates the expression of many detoxification and antioxidant enzymes. Nrf2 can potentially play a significant role in adaptive responses to oxidative stress. Nrf2 belongs to the Cap N Collar subfamily of basic leucine zipper (CNC-bZIP) transcription factors. The NF-E2 related family comprises of Nrf1 (TCFII), Nrf2, and Nrf3 and these proteins heterodimerize with Maf proteins to bind to Maf recognition element (MARE). Under normal conditions, Nrf2 is inactive and localized in the cytoplasm through its association with Keap1. When cells are exposed to electrophiles or oxidative stress generating agents cytoplasm localization of Nrf2 is inactivated and Nrf2 translocates into the nucleus and binds to specific DNA sequence elements known as NF-E2 binding site, Maf recognition element (MARE), stress response element or anti-oxidant response element (ARE). Studies have investigated the role of Nrf2 in urinary bladder carcinogenesis, pulmonary fibrosis, and smoke-induced emphysema. A study reported Nrf2-mediated ARE transcription to be a likely target of preventative therapy in neurodegenerative disorders such as Huntington's disease.

Catalog Number: (10069-008)
Supplier: Prosci
Description: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress through activation of NF-κ-B.


Supplier: ELECTRON MICROSCOPY SCIENCE
Description: Soft ESD safe ergonomic cushion grips (resistivity 10⁸ to 10⁹ Ohm) provide enhanced operator comfort and reduced finger stress when handling ESD sensitive components or small static items. Tips are carbon steel.

Supplier: Antyila Scientific
Description: Save money by replacing sensor, not the tester.

Supplier: VWR International
Description: The VWR® Advanced Melting Point Apparatus is used in determining the purity of a sample and is optimized to quickly and efficiently heat up to 3 samples at one time.

Environmentally Preferable Product available on GSA Advantage®

Catalog Number: (470019-728)
Supplier: Antyila Scientific
Description: The double junction electrode is ideal for dirty water, heavy metals, sulfides, tris buffers, and organics. The tester also features a pH and temperature readout toggle, automatic temperature compensation, and a replaceable sensor.


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