You Searched For: H-Lys(Me)\u2082-OH+\u00B7+HCl

Supplier: Biolegend

Description: Purified anti-mouse Ly-6A/E (Sca-1) [D7]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC, IHC, IP, WB; Size: 500 μg

Catalog Number: (CA108302-BL)

Supplier: Biolegend

Description: Purified anti-mouse Ly-51 [6C3]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC, IHC, IP; Size: 500 μg

Catalog Number: (10347-642)

Supplier: Bioss

Description: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death.

Catalog Number: (10347-656)

Supplier: Bioss

Description: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death.

Supplier: Biolegend

Description: PE anti-mouse Ly-6A/E (Sca-1) [E13-161.7]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC; Size: 200 μg

Supplier: Biolegend

Description: FITC anti-mouse Ly-6A/E (Sca-1) [E13-161.7]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC, IF; Size: 500 μg

Supplier: Biolegend

Description: Alexa Fluor® 647 anti-mouse Ly-51 [6C3]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC, IHC; Size: 100 μg

Supplier: Biolegend

Description: Alexa Fluor® 647 anti-mouse Ly-6G [1A8]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC, IHC-F; Size: 100 μg

Supplier: Biolegend

Description: Alexa Fluor® 700 anti-mouse Ly-6G [1A8]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC, IHC; Size: 100 μg

Catalog Number: (ABCA_AB319880-100U)

Supplier: Abcam

Description: Alexa Fluor® 555 Rabbit monoclonal [EPR3355] to Ly-6A/E (Sca-1).

New Product

Catalog Number: (ABCA_AB319738-100U)

Supplier: Abcam

Description: Alexa Fluor® 594 Rabbit monoclonal [EPR3355] to Ly-6A/E (Sca-1).

New Product

Catalog Number: (ABCA_AB319634-100U)

Supplier: Abcam

Description: Alexa Fluor® 647 Rabbit monoclonal [EPR3355] to Ly-6A/E (Sca-1).

New Product

Catalog Number: (103009-902)

Supplier: Anaspec Inc

Description: This is histone H3 (1-21) monomethylated at Lys9 followed by a biotinylated Lys at its C-terminus. Lys9 monomethylated histone H3 is associated with silent chromatin domains in euchromatin. This monomethylated state is also the preferred substrate for Suv39h1 and Suv39h2, the methyltransferases that catalyze Lys9 trimethylation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:ARTKQTAR-K(Me1)-STGGKAPRKQLA-K(Biotin)
MW:2623.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: (ABCA_AB319521-100U)

Supplier: Abcam

Description: Alexa Fluor® 488 Rabbit monoclonal [EPR3355] to Ly-6A/E (Sca-1).

New Product

Supplier: Anaspec Inc

Description: This peptide is Histone H3 amino acid residues 1 to 21 di-methylated at Lys-4 with a C-terminal GG linker followed by a biotinylated lysine. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:ART-K(Me2)-QTARKSTGGKAPRKQLA-GGK(Biotin)
MW:2751.2 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: (76752-736)

Supplier: Prosci

Description: Anti-LY 3090106 Recombinant Antibody