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Flt-3 inhibitor

Catalog Number: (CAAAJ64484-MA)
Supplier: Thermo Scientific Chemicals
Description: A cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor
Image Unavailable-76219-892

Flt-3 inhibitor ≥98.0% (by HPLC)

Supplier: TCI America
Description: 2-(3,4-Dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide, Purity: >98%(HPLC), CAS: 301305-73-7, MF: C18H20N2O4S, MW: 360.43, Synonyms: Flt-3 Inhibitor, TCS 359, Form: Crystal-Powder, Size: 100MG

Image Unavailable-89158-160

ZM-306416 ≥98% (by TLC)

Catalog Number: (89158-160)
Supplier: Enzo Life Sciences
Description: VEGF receptor tyrosine kinase inhibitor. Inhibits KDR (IC50=100nM) and Flt (IC50=2µM) tyrosine kinases.
Image Unavailable-77439-214

Anti-VEGFR1 Rabbit Polyclonal Antibody

Catalog Number: (77439-214)
Supplier: Bioss
Description: VEGF Receptor 1 (also known as FLT) belongs to the src gene family and shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The protein acts as a receptor for VEGF, VEGFB and PGF. An alternatively spliced form of the gene produces a soluble protein (sFlt1) which binds vascular endothelial growth factor (VEGF) with high affinity. sFlt1 has a higher affinity for VEGF indicating that it may function as an inhibitor in the VEGF response. VEGF Receptor 1 is specifically expressed in most vascular endothelial cells and peripheral blood monocytes.
Image Unavailable-89158-212

Midostaurin ≥98% (by TLC)

Supplier: Enzo Life Sciences
Description: Inhibitor of a variety of serine/threonine and tyrosine kinases, like protein kinase C (PKC), cyclic AMP-dependent protein kinase (PKA), S6 kinase, Akt (protein kinase B; PKB), epidermal growth factor receptor (EGFR) tyrosine kinase activity and others including KDR, VEGFR, PDGFR, c-kit and other receptor tyrosine kinases. Potently inhibits FLT-3 kinase including mutant forms found in acute myeloid leukemia in vitro and in vivo. Apoptosis inducer. Showed broad antiproliferative activity against various tumor cell lines. Selectively inhibits T lymphocyte production of TNF-α. Upregulates endothelial nitric oxide synthase (eNOS; NOS III). Abrogates tumor angiogenesis in vivo.

Product Image-77751-956

Mouse Recombinant FLT-3 LIGAND (from E. coli)

Supplier: VWR International
Description: Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signaling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3).

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Product Image-77751-162

Human Recombinant FLT-3 Ligand (from E. coli)

Supplier: VWR International
Description: <p>Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signalling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3). Human FLT-3 ligand is active on mouse cells.</p>

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Product Image-77751-126

Human Recombinant FLT-3 Ligand (from E. coli)

Supplier: VWR International
Description: <p>Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signalling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3). Human FLT-3 ligand is active on mouse cells.</p>

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Product Image-77753-176

Pig Recombinant FLT-3 Ligand (from E. coli)

Supplier: VWR International
Description: Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signaling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3).

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Product Image-77753-162

Pig Recombinant FLT-3 Ligand (from E. coli)

Supplier: VWR International
Description: <p>Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signaling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3).</p>

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Product Image-77753-352

Human Recombinant FLT-3 LIGAND (from E. coli)

Supplier: VWR International
Description: FLT-3 Ligand is a growth factor that regulates proliferation of early hematopoietic cells. FLT-3 Ligand binds to cells expressing the tyrosine kinase receptor FLT-3.

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Product Image-77751-950

Mouse Recombinant FLT-3 LIGAND (from E. coli)

Supplier: VWR International
Description: Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signaling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3).

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Product Image-77753-606

Mouse Recombinant HPC EXPANSION PB (from E. coli)

Catalog Number: (77753-606)
Supplier: VWR International
Description: Cytokines for expansion and cell culture of mouse hematopoietic stem cells to progenitor cells. Hematopoietic stem cells are self renewing pluripotent cells often characterized by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with the decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of SCF, FLT-3 Ligand, IL-6 and IL-3 for short time periods allows rapid expansion of immature and more mature hematopoietic progenitor cells in cord blood or bone marrow preparations. If the goal is to only expand the most immature progenitor and stem cells, it is recommended that a combination of TPO, SCF and FLT-3 Ligand are used (Catalog: PB-500-04). Either cytokine combination can also be supplemented with other cytokines to promote specific lineages.

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Product Image-77753-604

Human Hematopoietic Progenitor Cell Expansion Recombinant Protein Bundle

Catalog Number: (77753-604)
Supplier: VWR International
Description: Cytokines for expansion and cell culture of human hematopoietic stem cells to progenitor cells. Hematopoietic stem cells are self renewing pluripotent cells often characterized by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with the decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of SCF, FLT-3 Ligand, IL-6 and IL-3 for short time periods allows rapid expansion of immature and more mature hematopoietic progenitor cells in cord blood or bone marrow preparations.

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Product Image-77753-602

Mouse Recombinant Hematopoietic Stem Cell Expansion Protein Bundle (from E. coli)

Catalog Number: (77753-602)
Supplier: VWR International
Description: Cytokines for expansion and cell culture of mouse hematopoietic stem cells. Hematopoietic stem cells are self renewing pluripotent cells often characterized by the expression of CD34. Studies have shown that decreased expression of CD34 tends to correlate with decreased self renewal properties and pluripotent potential. Culturing CD34+ cells in a cytokine mixture of TPO, SCF, and FLT-3 Ligand for short time periods allows CD34+ cells to proliferate without decreasing CD34 expression, thus retaining their stem cell properties. The combination of these cytokines allows for the ex vivo expansion of the most immature hematopoietic stem cells in cord blood or bone marrow preparations, but can be supplemented with other cytokines to promote specific lineages.

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Image Unavailable-102869-088

Mouse Recombinant VEGFR1/Flt-1 (from NS0 cells)

Catalog Number: (102869-088)
Supplier: R&D Systems
Description: The Recombinant Mouse VEGF R1/Flt-1 Fc Chimera Protein from R&D Systems is derived from NS0. The Recombinant Mouse VEGF R1/Flt-1 Fc Chimera Protein has been validated for the following applications: Bioactivity.
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