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Image Unavailable-77440-476

Anti-CERD4 Rabbit Polyclonal Antibody

Catalog Number: (77440-476)
Supplier: Bioss
Description: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.
Image Unavailable-10420-606

Anti-SUV39H1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10420-606)
Supplier: Bioss
Description: SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.
Image Unavailable-76080-990

Anti-SUV39H1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76080-990)
Supplier: Bioss
Description: SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.
Image Unavailable-10421-712

Anti-SUV39H1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10421-712)
Supplier: Bioss
Description: SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus.
Product Image-10068-644

Anti-GATA1 Rabbit Polyclonal Antibody

Catalog Number: (10068-644)
Supplier: Prosci
Description: GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
Image Unavailable-CAPIPA5-15522

Anti-PTP alpha Rabbit Polyclonal Antibody

Catalog Number: (CAPIPA5-15522)
Supplier: Thermo Scientific
Description: Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
Product Image-CA76523-362

The Wizard™ CompactDry™ Reader 2 Colony Counter

Catalog Number: (CA76523-362)
Supplier: HARDY DIAGNOSTICS CA
Description: The Wizard™ CompactDry™ Reader 2 is a fast, easy, and accurate way to read, count, and record your CompactDry™ results. Just flip the switch, select your configuration, insert your CompactDry™ plate(s), select read, and save your results.
Product Image-10106-852

Anti-STAT6 Rabbit Polyclonal Antibody

Catalog Number: (10106-852)
Supplier: Prosci
Description: STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Product Image-76378-320

PIG® Grippy® Adhesive-Backed Absorbent Mats, New Pig

Catalog Number: (76378-320)
Supplier: New Pig
Description: Make the switch to the mat that sticks to prevent slips, trips and falls around workstations and walkways near machinery in industrial facilities.
Product Image-89133-390

Anti-RAS Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences
Description: Monomeric G-protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways. Oncogenic mutations, which occur in approximately 30% of all cases of human cancer, lead to the stimulation of proliferation and the inhibition of apoptosis.

SDS

Image Unavailable-10765-158

Anti-CD40 Mouse Monoclonal Antibody [clone: 5C3]

Catalog Number: (10765-158)
Supplier: Prosci
Description: The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.
Product Image-74670-014

UVP Portable/Rechargeable UV Lamps, Analytik Jena

Catalog Number: (74670-014)
Supplier: Analytik Jena US
Description: Rechargeable -26P Series UV Lamps offer versatility and variety in a powerful 6/12 watt rechargeable design. UVS-26P has two shortwave tubes. This model allows you to use two tubes at a time, or just one. UVL-26P has two longwave ultraviolet tubes. This model allows use of one or two tubes at a time. UVSL-26P has one shortwave and one longwave UV tube. This model allows use of one tube at a time. The toggle switch allows users to easily select longwave or shortwave UV.

Small Business Enterprise Product available on GSA Advantage®


Product Image-CA10065-194

Human Peripheral Blood CD4+ T Cells, Cryopreserved, 10 Million

Catalog Number: (CA10065-194)
Supplier: LONZA PHARMA - BIOSCIENCE CA
Description: CD4+ T cells are also known as helper T cells because they act on other cells of the immune system to promote various aspects of the immune response,including immunoglobulin isotype switching and affinity maturation of the antibody response,macrophage activation and enhanced activity of natural killer cells and cytotoxic T cells.

Certificates


Product Image-10100-636

Anti-CHRNG Rabbit Polyclonal Antibody

Catalog Number: (10100-636)
Supplier: Prosci
Description: For background information on the acetylcholine receptor (AChR), see CHRNA1. Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit, which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity.For background information on the acetylcholine receptor (AChR), see CHRNA1 (MIM 100690). Two forms of AChR are found in mammalian skeletal muscle cells. The mature form is predominant in innervated adult muscle and the embryonic form is present in fetal and denervated muscle. Embryonic and mature AChR differ by the replacement of the gamma subunit in the pentameric glycoprotein complex by its isoform, the epsilon subunit (MIM 100725), which is specific to the mature AChR subtype. This switch is mediated by ARIA (acetylcholine receptor-inducing activity; MIM 142445).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-2187 AK125362.1 1-2187
Image Unavailable-CA76413-056

Static Pen, Sartorius

Catalog Number: (CA76413-056)
Supplier: Sartorius
Description: This pen unit is used to neutralize static electricity on samples or objects to be weighed down to a level of 30V.
Image Unavailable-10471-300

Anti-AICDA Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10471-300)
Supplier: Bioss
Description: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
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