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Product Image-76378-320

PIG® Grippy® Adhesive-Backed Absorbent Mats, New Pig

Catalog Number: (76378-320)
Supplier: New Pig
Description: Make the switch to the mat that sticks to prevent slips, trips and falls around workstations and walkways near machinery in industrial facilities.
Image Unavailable-75789-384

Human Recombinant SLAMF6 (from Cells)

Catalog Number: (75789-384)
Supplier: Prosci
Description: SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN- gamma by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.
Image Unavailable-77440-476

Anti-CERD4 Rabbit Polyclonal Antibody

Catalog Number: (77440-476)
Supplier: Bioss
Description: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.
Image Unavailable-77439-562

Anti-PAX6 Rabbit Polyclonal Antibody

Catalog Number: (77439-562)
Supplier: Bioss
Description: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Image Unavailable-10471-298

Anti-AICDA Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10471-298)
Supplier: Bioss
Description: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Image Unavailable-10471-304

Anti-AICDA Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10471-304)
Supplier: Bioss
Description: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Image Unavailable-10471-302

Anti-AICDA Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10471-302)
Supplier: Bioss
Description: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Image Unavailable-10471-286

Anti-AICDA Rabbit Polyclonal Antibody

Catalog Number: (10471-286)
Supplier: Bioss
Description: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Product Image-CA10065-194

Human Peripheral Blood CD4+ T Cells, Cryopreserved, 10 Million

Catalog Number: (CA10065-194)
Supplier: LONZA PHARMA - BIOSCIENCE CA
Description: CD4+ T cells are also known as helper T cells because they act on other cells of the immune system to promote various aspects of the immune response,including immunoglobulin isotype switching and affinity maturation of the antibody response,macrophage activation and enhanced activity of natural killer cells and cytotoxic T cells.

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Image Unavailable-CA76413-056

Static Pen, Sartorius

Catalog Number: (CA76413-056)
Supplier: Sartorius
Description: This pen unit is used to neutralize static electricity on samples or objects to be weighed down to a level of 30V.
Product Image-10068-644

Anti-GATA1 Rabbit Polyclonal Antibody

Catalog Number: (10068-644)
Supplier: Prosci
Description: GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
Image Unavailable-CAPIPA5-15522

Anti-PTP alpha Rabbit Polyclonal Antibody

Catalog Number: (CAPIPA5-15522)
Supplier: Thermo Scientific
Description: Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
Image Unavailable-10765-158

Anti-CD40 Mouse Monoclonal Antibody [clone: 5C3]

Catalog Number: (10765-158)
Supplier: Prosci
Description: The 5C3 monoclonal antibody specifically reacts with human CD40, a 48kDA type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.
Product Image-74670-014

UVP Portable/Rechargeable UV Lamps, Analytik Jena

Catalog Number: (74670-014)
Supplier: Analytik Jena US
Description: Rechargeable -26P Series UV Lamps offer versatility and variety in a powerful 6/12 watt rechargeable design. UVS-26P has two shortwave tubes. This model allows you to use two tubes at a time, or just one. UVL-26P has two longwave ultraviolet tubes. This model allows use of one or two tubes at a time. UVSL-26P has one shortwave and one longwave UV tube. This model allows use of one tube at a time. The toggle switch allows users to easily select longwave or shortwave UV.

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Product Image-CA89511-336

Accessories for WXTS Microbalance, Mettler Toledo

Catalog Number: (CA89511-336)
Supplier: Mettler Toledo
Product Image-10822-100

Mouse Recombinant IL-4 (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.

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