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Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components

Catalog Number: 103010-232

Supplier: Anaspec Inc

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Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components

Catalog Number: 103010-154

Supplier: Anaspec Inc

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Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components

Catalog Number: 103010-238

Supplier: Anaspec Inc

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Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components

Catalog Number: 103010-152

Supplier: Anaspec Inc

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Description: MMP-10 (stromelysin 2) cleaves extracellular matrix proteins, but is unable to cleave the triple-helical fibrillar collagens

Catalog Number: 103010-302

Supplier: Anaspec Inc

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Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components

Catalog Number: 103010-164

Supplier: Anaspec Inc

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Description: InSolution Caspase Inhibitor VI

Catalog Number: CA60801-212

Supplier: MilliporeSigma

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Description: A cell-permeable, irreversible, broad-spectrum caspase inhibitor.

Catalog Number: CA80050-800

Supplier: MilliporeSigma

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Description: Human MMP-9 (from Neutrophil)

Catalog Number: CA80053-078

Supplier: MilliporeSigma

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Description: The MMP-12 Antibody (703D10) from Novus Biologicals is a mouse monoclonal antibody to MMP-12. This antibody reacts with human, canine. The MMP-12 Antibody (703D10) has been validated for the following applications: Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

Catalog Number: 103318-830

Supplier: Novus Biologicals

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Description: A boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (80053-194, -196) but displays much higher potency (Ki=0.03nM vs)

Catalog Number: CA80109-738

Supplier: MilliporeSigma

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Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens. Recombinant Human MMP-1 is a 42.7 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain, which is involved in substrate specificity, and in binding TIMP-1.

Catalog Number: 76303-880

Supplier: Peprotech

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Description: A potent and cell-permeable proteasome inhibitor

Catalog Number: CA80053-880

Supplier: MilliporeSigma

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Description: A potent and reversible inhibitor of caspase-1 (ICE), caspase-3, caspase-4, and caspase-7.

Catalog Number: CA80050-774

Supplier: MilliporeSigma

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Description: Recombinant, human pro-MMP-3 purified from cell culture supernatant. May be used as a positive control or standard for zymographic analysis, or substrate assay. Requires activation for immunoblotting, prior to use. M.W. 57000/58000. Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for the degradation of extracellular matrix components such as collagen, laminin and proteoglycans. In addition to sequence homology, all MMPs share the following characteristics: the catalytic mechanism is dependent upon a zinc ion at the active center, they cleave one or more extracellular matrix components, they are secreted as zymogens which are activated by removal of an approximately 10 kDa segment from the N terminus and they are inhibited by tissue inhibitor of metalloproteinases (TIMP). These enzymes are involved in normal physiological processes such as embryogenesis and tissue remodeling and may play an important role in angiogenesis, arthritis, periodontitis, and metastasis. Matrix metalloproteinase-3 (MMP-3) also known as stromelysin-1 and transin (EC 3.4.24.17) cleaves a number of substrates including cartilage proteoglycan, collagen types II, III, IV, V and IX, fibronectin, laminin, and can activate MMP 1. MMP-3 is secreted as ~57 and ~59 kDa proenzymes and can be activated in vitro by organomercurials (e.g., 4 aminophenylmercuric acetate, APMA) and in vivo by proteases via intermediate forms to a 45 kDa active MMP 3 enzyme. Further autolysis to a ~28 kDa form can also occur. MMP-3 is thought to play an important role in pathophysiological degradation processes associated with conditions such as rheumatoid arthritis and cancer cell invasion.

Catalog Number: CA80001-992

Supplier: MilliporeSigma

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Description: A cell-permeable and irreversible inhibitor of caspase-1 (Ki=760pM) and caspase-4

Catalog Number: CA80052-272

Supplier: MilliporeSigma

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