You Searched For: Copper+(II)+trifluoromethanesulphonate

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Anti-RNAP2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10458-828)

Supplier: Bioss

Description: RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The largest subunit of Pol II (referred to as RPB1 or RPB205) is a 1,840 amino acid protein that contains one C2H2-type zinc finger and a C-terminal domain comprised of several heptapeptide repeats. Although Pol II function requires the cooperation of all twelve subunits, the largest subunit conveys Pol II catalytic activity and, together with the second largest subunit, forms the active center of the Pol II enzyme. Additionally, the large subunit participates in forming the DNA-binding domain of Pol II, a groove that is necessary for transcription of the DNA template. Without proper function of the large subunit, mRNA synthesis and subsequent transcription elongation cannot occur.

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Anti-TGF beta Receptor II Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10231-722)

Supplier: Bioss

Description: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

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390 MMP FRET Substrate II, Mca-DNP

Catalog Number: (102996-764)

Supplier: Anaspec Inc

Description: Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a generic fluorogenic substrate for assaying MMPs. Abs/Em = 325/393 nm.
Sequence:Mca-PLGL-Dap(Dnp)-AR
MW:1094.2 Da
% peak area by HPLC:95
Storage condition:-20° C

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Ammonia solution 20%, ULTREX® II, Ultrapure for trace metal analysis, J.T.Baker®

Catalog Number: (CAJT4807-5)

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: Certificate of lot analysis provided.

Certificates

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AccuStart™ II PCR Genotyping Kit, Quantabio

Supplier: Quantabio

Description: The AccuStart™ II PCR Genotyping Kit is designed for fast and easy preparation of PCR-ready DNA extracts and endpoint PCR analysis from tissues such as tail snips and ear punches commonly used for genotyping knockout and transgenic animals

Certificates

Anti-MHC Class II beta Rabbit Monoclonal Antibody [clone: EPR11227]

Supplier: Abcam

Description: Rabbit monoclonal [EPR11227] to MHC Class II beta - BSA and Azide free.

New Product

Anti-Topoisomerase II alpha (phospho T1343) Rabbit Monoclonal Antibody [clone: EP1054Y]

Supplier: Abcam

Description: Rabbit monoclonal [EP1054Y] to Topoisomerase II alpha (phospho T1343) - BSA and Azide free.

New Product

Anti-Topoisomerase II alpha (phospho S1106) Rabbit Monoclonal Antibody [clone: EP2722]

Supplier: Abcam

Description: Rabbit monoclonal [EP2722] to Topoisomerase II alpha (phospho S1106) - BSA and Azide free.

New Product

Anti-TOPO II Alpha Ser1106 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76084-178)

Supplier: Bioss

Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

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PfuUltra II Fusion HS DNA Polymerase, Agilent Technologies

Supplier: AGILENT TECHNOLOGIES (GENOMICS) CA

Description: This DNA polymerase is ideal for a variety of techniques requiring high-fidelity DNA synthesis by the polymerase chain reaction (PCR).