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Image Unavailable-75789-852

Human Recombinant S100 calcium binding A12 (from E. coli)

Catalog Number: (75789-852)
Supplier: Prosci
Description: Human EN-RAGE belongs to the S100/calgranulin superfamily. There are at least 21 different S100 proteins and the protein is 100% soluble in ammonium sulfate at neutral pH. S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.Human EN-RAGE is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+from their active sites.
Image Unavailable-CA80051-786

Fura-2 LR/AM ≥95% (by HPLC) fluorescent indicator, for calcium determination, Calbiochem®

Supplier: MilliporeSigma
Description: Acetoxymethyl (AM) derivative of FURA-PE3 with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM. Hydrolysis by non-specific esterases traps the indicator in the cytosol. Compared to FURA-2, it is retained longer in the cell.

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Image Unavailable-10486-200

Anti-CASR Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10486-200)
Supplier: Bioss
Description: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Product Image-76577-064

Bovine Inducible Nitric Oxide Synthase (iNOS)ELISA Kit, AFG Bioscience

Catalog Number: (76577-064)
Supplier: AFG Bioscience
Description: Bovine Inducible Nitric Oxide Synthase (iNOS)ELISA Kit, AFG Bioscience
Product Image-76711-458

Human Oxidized High Density Lipoprotein (Ox HDL) ELISA Kit

Catalog Number: (76711-458)
Supplier: AFG Bioscience
Description: Human Oxidized High Density Lipoprotein (Ox HDL) ELISA Kit
Product Image-470300-636

Calcium Phosphate Monobasic, Monohydrate

Catalog Number: (470300-636)
Supplier: Ward's Science
Description: CAS Number: 10031-30-8
Formula Weight: 252.08
Formula: CaH4(PO4)2·H2O
Density (g/mL): 1.2
Freezing Point (°C): 200
Synonyms: Monocalclium Phosphate Monohydrate
Shelf Life (months): 36
Storage: Green

SDS


Product Image-76710-736

Mouse Oxidized High Density Lipoprotein (Ox-HDL) ELISA Kit

Catalog Number: (76710-736)
Supplier: AFG Bioscience
Description: Mouse Oxidized High Density Lipoprotein (Ox-HDL) ELISA Kit
Product Image-76708-766

Human Oxidized Low Density LipoProtein Antibody, OLAb ELISA Kit

Catalog Number: (76708-766)
Supplier: AFG Bioscience
Description: Human Oxidized Low Density LipoProtein Antibody, OLAb ELISA Kit
Product Image-76577-854

Bovine Endothelial Nitric Oxide Synthase (eNOS) ELISA Kit, AFG Bioscience

Catalog Number: (76577-854)
Supplier: AFG Bioscience
Description: Bovine Endothelial Nitric Oxide Synthase (eNOS) ELISA Kit, AFG Bioscience
Product Image-470300-150

Aluminum Oxide

Supplier: Ward's Science
Description: CAS Number: 1344-28-1
Formula Weight: 101.96
Formula: Al2O3
Hazard Info: Irritant, Nuisance
Density (g/mL): 3.5
Boiling Point (°C): 2980
Freezing Point (°C): 2050
Solubility: Insoluble in Water, Low solubility in Acids
Synonyms: Alumina, Aluminum Trioxide
Shelf Life (months): 36
Storage: Green

SDS

Product Image-77664-474

Nitric Oxide Macro Sensor

Catalog Number: (77664-474)
Supplier: WORLD PRECISION INSTRUMENTS LLC
Description: The ISO-NOP is a popular, robust and high performance sensor encased within a 2 mm diameter disposable stainless steel protective sleeve. The tip of the sleeve is covered with a NO-selective membrane. Replacement membrane sleeves can be purchased separately and require an internal electrolyte.

New Product


Image Unavailable-BJBR666-56

Oxidation reagent 0.02 M I₂ in 70/20/10 THF/pyridine/water (v/v), BioSyn™ for DNA/RNA synthesis, Burdick & Jackson™

Supplier: Honeywell Research Chemicals
Description: Burdick & Jackson® BioSyn® reagents & solvents for DNA/RNA synthesis

SDS

Product Image-470300-844

Copper(II) Oxide (Black)

Supplier: Ward's Science
Description: CAS Number: 1317-38-0
Formula Weight: 79.54
Formula: CuO
Hazard Info: Toxic
Density (g/mL): 6.0
Freezing Point (°C): 1234
Solubility: Acids
Synonyms: Cupric Oxide, Black
Shelf Life (months): 36
Storage: Green

SDS

Product Image-76707-342

Mouse Calcium/Calmodulin-dependent Protein Kinase Type II Subunit beta(CAMK2B) ELISA Kit

Catalog Number: (76707-342)
Supplier: AFG Bioscience
Description: Mouse Calcium/Calmodulin-dependent Protein Kinase Type II Subunit beta(CAMK2B) ELISA Kit
Image Unavailable-10486-410

Anti-CASR Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10486-410)
Supplier: Bioss
Description: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
Image Unavailable-10486-198

Anti-CASR Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10486-198)
Supplier: Bioss
Description: Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system.
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