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You Searched For: CL-82198+(MMP-13+inhibitor)


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Product Image-10752-048

Anti-MMP9 Rabbit Polyclonal Antibody

Catalog Number: (10752-048)
Supplier: Prosci
Description: The matrix metalloproteinase (MMP) family are a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP9 degrades type IV and V collagens and studies suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow and plays a role in tumor-associated tissue remodeling.
Image Unavailable-77440-004

Anti-MMP12 Rabbit Polyclonal Antibody

Catalog Number: (77440-004)
Supplier: Bioss
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis, metastasis, and atherosclerosis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.<br> MMP12 was first described in murine macrophages, later in human macrophages, and more recently in other cell types. Also known as metalloelastase, MMP12 is able to degrade elastin, entactin, laminin 1, fibronectin, type IV collagen as well as insulin B-chain and casein. MMP12 is often confused with the Serine proteinase, Leukocyte elastase (EC 3.4.21.37) because of similar nomenclature. MMP12 is structurally similar to the classical MMPs (MMP1, MMP3); it contains a propeptide with autoinhibitory cysteine switch site, a well-conserved zinc site, hinge region and hemopexin domain. MMP12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kD, and is quickly activated to the 45 kD form; and this breaks down to cascade of active forms, ending with the common 22 kD form. Stimulated macrophages produce MMP12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts.
Product Image-77048-936

Anti-MMP11 Rabbit Polyclonal Antibody

Catalog Number: (77048-936)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to MMP-11 for WB, IHC, IF and ELISA with samples derived from Human, Mouse and Rat.
Image Unavailable-89351-754

Anti-MMP9 Rabbit Polyclonal Antibody

Catalog Number: (89351-754)
Supplier: Genetex
Description: MMPs (Matrix Metalloproteinases) are proteolytic enzymes capable of degrading connective tissue components. MMPs play a crucial role in tumor cell invasion and metastasis.
Product Image-10105-156

Anti-MMP19 Rabbit Polyclonal Antibody

Catalog Number: (10105-156)
Supplier: Prosci
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. They are also involved in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The function of the protein encoded by this gene has not been determined. This gene was previously referred to as MMP18 but has been renamed matrix metalloproteinase 19 (MMP19). Multiple transcript variants encoding distict isoforms have been identified for this gene.
Product Image-89156-936

Oligomycin A ≥97% (by HPLC, TLC)

Supplier: Enzo Life Sciences
Description: Inhibits mitochondrial ATPases (F<sub>1</sub>F<sub>0</sub>)

Image Unavailable-CAPIPA5-13179

Anti-MMP10 Rabbit Polyclonal Antibody

Catalog Number: (CAPIPA5-13179)
Supplier: Thermo Scientific
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP10 degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Image Unavailable-103005-950

580 MMP FRET Substrate I, QXL™ 570-TAMRA, AnaSpec

Catalog Number: (103005-950)
Supplier: Anaspec Inc
Description: Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
With the higher emission wavelength, this substrate is ideal for use in experiments where the test compounds might have strong autofluorescence at shorter wavelength, Abs/Em = 547/574 nm.
Sequence:QXL™ 570-KPLA-Nva-Dap(5-TAMRA)-AR-NH2
MW:1768 Da
% peak area by HPLC:95
Storage condition:-20° C
Product Image-76262-738

Anti-TP53 Rabbit Polyclonal Antibody

Catalog Number: (76262-738)
Supplier: Rockland Immunochemical
Description: TP53 (tumor suppressor gene p53) is one of the most well-studied genes that suppresses tumor formation and renders protection against DNA damage by inducing cell cycle arrest, DNA repair, or apoptosis. TP53 signaling is triggered through numerous cellular events ranging from DNA damage to hypoxia, stress and a plethora of other causes. Upon activation, p53 acts as zinc-containing transcriptional regulator and initiates a cascade of events that determines the cellular outcome including cell cycle arrest, apoptosis, senescence, DNA repair, development, differentiation and tissue homeostasis. Cell cycle arrest is induced by p53 via trans-activating genes such as p21 (CDK-inhibitor 1, cyclin dependent kinase) and others. Interestingly, p53 itself is capable of triggering cellular responses (survival or induced cell death) as well. Mutations or deletions in the TP53 gene are present in nearly 50% of human cancers, and primarily results in impaired tumor suppressor function. Anti-p53 (ac Lys305) antibody is ideal for researchers interested in developmental biology, cell growth and cancer research.
Product Image-76262-722

Anti-TP53 Rabbit Polyclonal Antibody

Catalog Number: (76262-722)
Supplier: Rockland Immunochemical
Description: TP53 (tumor suppressor gene p53) is one of the most well-studied genes that suppresses tumor formation and renders protection against DNA damage by inducing cell cycle arrest, DNA repair, or apoptosis. TP53 signaling is triggered through numerous cellular events ranging from DNA damage to hypoxia, stress and a plethora of other causes. Upon activation, p53 acts as zinc-containing transcriptional regulator and initiates a cascade of events that determines the cellular outcome including cell cycle arrest, apoptosis, senescence, DNA repair, development, differentiation and tissue homeostasis. Cell cycle arrest is induced by p53 via trans-activating genes such as p21 (CDK-inhibitor 1, cyclin dependent kinase) and others. Interestingly, p53 itself is capable of triggering cellular responses (survival or induced cell death) as well. Mutations or deletions in the TP53 gene are present in nearly 50% of human cancers, and primarily results in impaired tumor suppressor function. Anti-p53 (ac Lys292) antibody is ideal for researchers interested in developmental biology, cell growth and cancer research.
Product Image-77070-814

Anti-MMP15 Rabbit Polyclonal Antibody

Catalog Number: (77070-814)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to MMP-15 for WB and ELISA with samples derived from Human and Mouse.
Product Image-77050-996

Anti-MMP16 Rabbit Polyclonal Antibody

Catalog Number: (77050-996)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to MMP-16 for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.
Image Unavailable-102979-992

Anti-COL1 Rabbit Polyclonal Antibody

Catalog Number: (102979-992)
Supplier: Adipogen
Description: The proteolysis of collagens plays an important role in numerous physiological and pathological situations such as morphogenesis, wound healing, arthritis, arteriosclerosis and tumor metastasis. Triple helical type I collagens are made up of two alpha1 (I) and one alpha2 (I) chains, and are found in skin, tendon, ligament and interstitial tissues. Due to their fibrillary structure native collagens are resistant to most proteases. They are substrates for certain matrix metalloproteinases (MMPs), which constitute a family of zinc-dependent enzymes catalyzing the degradation of extracellular matrix components. Initial MMP-8 dependent cleavage of collagen into the characteristic ¾ and ¼ fragments has been shown to enable MMP-9 diffusion along the protein helix with preferential binding to the collagen ¾ fragment tail. Finally, untwisting of the helix end results in the local denaturation of the triple helical structure.
Product Image-10105-480

Anti-MMP9 Rabbit Polyclonal Antibody

Catalog Number: (10105-480)
Supplier: Prosci
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Image Unavailable-89143-926

Human MMP-1 proenzyme (from Fibroblasts)

Catalog Number: (89143-926)
Supplier: Enzo Life Sciences
Description: Isolated from human rheumatoid synovial fibroblasts. Requires activation.
Image Unavailable-10435-430

Anti-NET1 Rabbit Polyclonal Antibody

Catalog Number: (10435-430)
Supplier: Bioss
Description: Catecholamine, a term used for the hormone adrenaline and its sequentially hydroxylated form noradrenaline, is involved in fight or flight responses. Noradrenaline is released from the post ganglionic sympathetic nerve endings and exerts its effects locally in the immediate vicinity of its release. In the CNS, noradrenaline is involved in a number of physiological responses including mood, sleep regulation, alertness and arousal, both cognitive and non-cognitive expression of behaviors, and control of the endocrine and autonomic nervous systems. Peripherally, noradrenaline is present in sympathetic nerve endings and has full control of the sympathetic nervous system. Noradrenaline released from pre-synaptic nerve terminals is reabsorbed (70-90%) by noradrenaline transporters and its biological effects are terminated. The noradrenaline transport via noradrenaline transporters is an active, Na+/Cl- dependent transport process mediated by noradrenaline transporters. Noradrenaline transporters constitute the primary mechanism for inactivation of synaptically released noradrenaline, are targets for multiple antidepressants and psychostimulants, and are deficient in affective and autonomic disorders. In rat brain, noradrenaline transporter is expressed in noradrenergic neuronal somata, axons and dendrites, and hippocampus and cortex, but is absent from epinephrine- and dopamine-containing neurons. At least 13 genetic variations have been reported in the noradrenaline transporter protein that affect noradrenaline re-uptake and concentrations in cerebrospinal fluid in humans. The association between these genetic variations in noradrenaline transporters and several psychiatric and cardiovascular disorders is just emerging. Recently, a single amino acid mutation (hNET-A457P) showed deficiency in noradrenaline transport in an orthostatic intolerance patient.
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