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Product Image-10085-740

Anti-DDI1 Rabbit Polyclonal Antibody

Catalog Number: (10085-740)
Supplier: Proteintech
Description: Ddi1(DNA-damage inducible 1)appears to release substrate from an ubiquitination complex, making the substrate available for deubiquitination to facilitate proteasomal degradation. Ddi1 could be a potential selective target for lung cancer treatment. Ddi1 runs as a doublet of 54/56 kDa on acrylamide gels besides the caculated MW 44 kDa.
Product Image-75792-802

Anti-ADIPOQ Mouse Monoclonal Antibody [clone: HADI 773]

Catalog Number: (75792-802)
Supplier: Prosci
Description: ACRP30 was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, ACRP30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased ACRP30 levels.
Image Unavailable-H-1156.0025BA

Ac-Ser-Asp-Lys-Pro-OH

Supplier: Bachem Americas
Description: The bioactive tetrapeptide goralatide which corresponds to the N-terminus of Thymosin β₄, is a physiological regulator of hematopoiesis and inhibits the entry into the S-phase of murine and human hematopoietic stem cells. Ac-SDKP has been shown to reduce the damage to specific compartments in the bone marrow resulting from treatment with chemotherapeutic agents, ionizing radiations, hyperthermy, or phototherapy. It protects from doxorubicin-induced toxicity. Ac-SDKP is a physiological substrate of angiotensin I- converting enzyme (ACE).

Product Image-10797-758

Human Recombinant PD14 (from HEK293 Cells)

Catalog Number: (10797-758)
Supplier: Prosci
Description: Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-?. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-? by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-? secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
Product Image-76424-378

Spotsee Forehead Thermometer Temperature Strip, Propper

Catalog Number: (76424-378)
Supplier: Propper
Description: During any illness outbreak, early fever detection not only helps prevent the spread of illnesses, it also ensures faster treatment. Liquid crystal technology-based, an FDA registered forehead thermometer provide a simple, cost-effective tool for monitoring body temperature.
Image Unavailable-H-7435.0001BA

Acetyl-Hirudin (55-65) (Sulfated)

Catalog Number: (H-7435.0001BA)
Supplier: Bachem Americas
Description: These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.
Image Unavailable-75994-886

arium® mini plus Ultrapure Laboratory Water Systems, Sartorius (Starter Packs)

Supplier: Sartorius
Description: The arium® mini plus is directly connected to a feed water tap. The feed water is treated by a special designed pre-treatment cartridge, which consists of a combination of activated carbon and a reverse osmosis module.

Product Image-76516-452

PURELAB® Chorus 2+ Water Purification System, ELGA LabWater

Catalog Number: (76516-452)
Supplier: ELGA LabWater
Description: The PURELAB Chorus 2+ range provide >15 MΩ.cm pure water. The systems provide additional bacteria and inorganic quality for sensitive analytical and life science applications above that of basic laboratory work. With its simple design and ease of use, water can be dispensed from the system or from a choice of additional Halo Dispensers.
Product Image-470315-142

Stem Investigations: Design a Water Filter

Catalog Number: (470315-142)
Supplier: Ward's Science
Description: How is the water that comes out of our faucets made safe for consumption?
Product Image-76516-456

PURELAB® Chorus 3 Water Purification System, ELGA LabWater

Catalog Number: (76516-456)
Supplier: ELGA LabWater
Description: When general laboratory grade water (Type III) is all you need, then PURELAB Chorus 3 is the reliable solution with the flexibility to suit your requirements.
Image Unavailable-H-1346.1000BA

Galanin (1-13)-Bradykinin (2-9) amide

Supplier: Bachem Americas
Description: The galanin antagonist M35, which binds with high specificity and affinity to galanin binding sites, has been administered to rats to test the functional consequences of the galanin receptor blockade in a spatial learning task. The results suggest that galanin antagonists might provide a new principle in the treatment of dementia and related disorders. M35 (but not M40 or C7) ameliorated cerulein-induced acute pancreatitis in mice.

Image Unavailable-10481-176

Anti-DPYD Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10481-176)
Supplier: Bioss
Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
Image Unavailable-10481-180

Anti-DPYD Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10481-180)
Supplier: Bioss
Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
Image Unavailable-H-4060.0025BA

(Des-Gly¹⁰,D-Leu⁶,Pro-NHEt⁹)-LHRH Acetate

Supplier: Bachem Americas
Description: LHRH is also called Gonadotropin-Releasing Hormone (GnRH) or Luteinizing Hormone-Releasing Factor (LRF).

Product Image-76333-932

Water Bath Protective Agent, polyclear MIX 30 PLUS, PolyScience

Catalog Number: (76333-932)
Supplier: Polyscience
Description: General purpose fluid that prevents algae growth and premature rust formation. Ideal for use in heating baths, circulators, water baths and shaking water baths.

Certificates


Product Image-CA89500-750

Surface Water Test Kit, Hach

Catalog Number: (CA89500-750)
Supplier: Hach
Description: The ideal tool for source water monitoring and wastewater treatment plants, this kit uses drop count titration and color disc methods to provide economical, easy-to-use tests for ammonia, chlorine, pH, nitrate, dissolved oxygen, phosphorus, and temperature

SDS


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