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Product Image-97008-268

VWR®, Accessories for VWR® CryoPro® Auto-Fill Vapor Phase Systems AF-VPS

Supplier: VWR International
Description: Frame Dimensions: 3.2 x 0.5 x 30.75in.

Small Business Enterprise Product available on GSA Advantage®

Product Image-MFLX95257-02

Hubtron™ Black Pascal Fluoroelastomer Tubing

Catalog Number: (MFLX95257-02)
Supplier: VWR International
Description: Ideal for corrosive chemical transfer.
Product Image-MFLX75226-12

Masterflex® Magnetic Drive Centrifugal Pump, Avantor®

Supplier: VWR International
Description: Heavy-duty impeller spindle and fluted impeller combine for efficient cooling.

Image Unavailable-10493-716

Anti-SLC39A11 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10493-716)
Supplier: Bioss
Description: Zinc is an essential cofactor that is involved in cell growth and development, as well as in protein, nucleic acid and lipid metabolism. The transport of zinc across the cell membrane is crucial for correct enzyme and overall cell function. SLC39A11 (solute carrier family 39 (metal ion transporter), member 11), also known as ZIP11 (Zrt- and Irt-like protein 11), is a 342 amino acid multi-pass membrane protein belonging to the ZIP transporter family. Expressed as multiple alternatively spliced isoforms, SLC39A11 acts as a zinc-influx transporter and is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes, some of which are involved in tumor suppression and in the pathogenesis of Li-Fraumeni syndrome, early onset breast cancer and a predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Image Unavailable-10489-834

Anti-TMIGD1 Rabbit Polyclonal Antibody

Catalog Number: (10489-834)
Supplier: Bioss
Description: Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dubé syndrome and Canavan disease are also associated with chromosome 17.
Image Unavailable-10496-304

Anti-TSSK6 Rabbit Polyclonal Antibody

Catalog Number: (10496-304)
Supplier: Bioss
Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
Image Unavailable-10496-316

Anti-TSSK6 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10496-316)
Supplier: Bioss
Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
Image Unavailable-10493-804

Anti-C17ORF49 Rabbit Polyclonal Antibody

Catalog Number: (10493-804)
Supplier: Bioss
Description: C17orf49 is a 172 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
Product Image-MFLX95603-30

Masterflex® Ismatec® Pump Tubing, 3-Stop Color-Coded Autoanalysis/Microbore, Platinum-Cured Silicone, Avantor®

Catalog Number: (MFLX95603-30)
Supplier: VWR International
Description: Designed for optimal operation in your Ismatec pumps.
Image Unavailable-CA76634-406

Anti-MLH-1 Mouse Monoclonal Antibody [clone: G168-15]

Catalog Number: (CA76634-406)
Supplier: Diagnostic Biosystems
Description: The G168-15 antibody recognizes human and mouse MLH1 (80 to 85 kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
Image Unavailable-CAPIPA5-13811

Anti-CKBB Rabbit Polyclonal Antibody

Catalog Number: (CAPIPA5-13811)
Supplier: Thermo Scientific
Description: Creatine Kinase (CK) is a dimeric enzyme composed of either M- or B-type subunits. The resulting isoenzymes are expressed at varying levels in different tissues. CK-BB, a cytoplasmic predominantly found in brain tissues, participates in energy homeostasis, reversibly catalyzing the transfer of a phosphate group between ATP and target proteins such as a creatine phosphate. CK-BB exists in normally neglible amounts in the serum of adults, overexpression of CK-BB is associated with cancers of the breast, ovary, prostate, colon, and in small-cell lung cancer. Global assessment of changes in serum levels of CK-BB, CK-MB and CK-MM, are used as a marker for myocardial infarction.
Product Image-MFLX45504-84

Masterflex® Adapter Fittings, Male Luer to Threaded, Straight, Avantor®

Supplier: VWR International
Description: Easily transition between luer fittings and UNF or NPT threads.

Certificates CE certificate

Product Image-10206-194

Anti-CEA Mouse Monoclonal Antibody [clone: CEA-9]

Catalog Number: (10206-194)
Supplier: Boster Biological Technology
Description: Mouse IgG monoclonal antibody for CEA, carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) detection. Tested with WB, IHC-P in Human. No cross reactivity with other proteins.
Product Image-10084-624

Anti-CSK Mouse Monoclonal Antibody [clone: 3B12C5]

Catalog Number: (10084-624)
Supplier: Proteintech
Description: CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration. Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells. This protein can be autophosphorylated.
Product Image-MFLX45504-06

Masterflex® Adapter Fittings, Male Luer to Hose Barb, Straight, Polycarbonate, Avantor®

Supplier: VWR International
Description: Ensure your process integrity with full material traceability.

Certificates Avantor exclusive CE certificate

Image Unavailable-10350-836

Anti-HDAC4 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10350-836)
Supplier: Bioss
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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