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Product Image-10081-620

Anti-MEF2C Rabbit Polyclonal Antibody

Catalog Number: (10081-620)
Supplier: Proteintech
Description: MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. This antibody is a rabbit polyclonal antibody raised against an internal 161Aa region of human MEF2C.
Product Image-10081-614

Anti-MEF2C Rabbit Polyclonal Antibody

Catalog Number: (10081-614)
Supplier: Proteintech
Description: MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. This antibody is a rabbit polyclonal antibody raised against an internal region of human MEF2C.
Product Image-10081-616

Anti-MEF2C Rabbit Polyclonal Antibody

Catalog Number: (10081-616)
Supplier: Proteintech
Description: MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. The immunogen used is peptide from Beta domain of MEF2C. The antibody can recognize the transcript variant 1 and transcript variant 3 of MEF2C.
Image Unavailable-77439-842

Anti-Ki-67 Rabbit Polyclonal Antibody

Catalog Number: (77439-842)
Supplier: Bioss
Description: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Image Unavailable-76120-948

Anti-KCNG2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76120-948)
Supplier: Bioss
Description: Neuronal and cardiac cells are excited by voltage-gated ion channels. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. Mutations interfering with potassium ion channels are known to cause a variety of disorders. KCNG2 (potassium voltage-gated channel subfamily G member 2) is also known as voltage-gated potassium channel subunit KV6.2, cardiac potassium channel subunit or KCNF2 and is a 466 amino acid protein. KCNG2 is a multi-pass membrane protein abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and detected at lower concentrations in brain, lung and placenta. KCNG2 is an electrically silent subunit that forms heterodimers with KV2.1, creating a unique functional K+ channel. KCNG2-KV2.1 heterodimers are known to be inhibited by tetraethylammonium and propafenone. KCNG2 is thought to downregulate potassium channel currents because KCNG2-KV2.1 heterodimers generate smaller currents than KV2.1 homodimers.
Product Image-89022-934

ESD Conveyor/Assembly Tray, MFG Tray

Supplier: Molded Fiber Glass Tray
Description: Used in the assembly of circuit boards, computers, medical device, and other types of electronic or static sensitive assembly

Product Image-VF-10166

Enviralab® Sterility Modules (ESM), Envirco®

Supplier: Envirco
Description: These self-contained, laminar flow clean benches feature a modular design with an airflow pattern that offers the non-aspirating action of vertical flow while retaining the positive work protection of horizontal flow

CSA Certified

Product Image-97006-986

Base Stands and Accessories for Purifier® Logic® Series Class II Safety Cabinets, Labconco®

Supplier: Labconco
Description: Logic Cart fits under any telescoping base stand. Features three small and one large compartments, one drawer, front panel cut out for dispensing wipers or gloves, and HDPE worksurface. W×D×H: 635×483×686 mm (25×19×27").

Product available on GSA Advantage®

Product Image-470203-136

Basic 47 and 70 Fume Hoods

Supplier: Labconco
Description: Ideal for rooms with shallow countertops or ceilings below 8', these hoods are constructed of sturdy, epoxy-coated steel both inside and out.<BR><BR>Furnished with a 3/16" tempered safety glass counterbalanced sash and duct collar, the hoods ensure your students’ safety. A removable front panel and air foil, vapor-proof interior light, and two-piece adjustable baffle make for easy access and convenient use.<BR><BR>The right side fixture is factory prepared to accept up to three service fixtures, one duplex electrical receptacle, and air monitor. The side wall is factory prepared for a wall-mounted cupsink with turret. Hoods are available in two model types – Basic 47 Hoods with a 4' nominal width are designed as an individual lab station, <BR><BR>Basic 70 Hoods are 6' in width and spacious enough to accomodate numerous samples or workstations.<BR><BR>Both models are available with or without a blower. Blowers may be mounted in or above the hood, or on the roof. Basic 47 hoods that include a blower have a 3/4 hp motor. <BR><BR>Note: Worksurface, base cabinet, and blower are required for operation, and sold separately.<BR><BR>For assistance, contact your local sales representative

Image Unavailable-76109-804

Anti-TRPM4 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76109-804)
Supplier: Bioss
Description: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Image Unavailable-76109-802

Anti-TRPM4 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76109-802)
Supplier: Bioss
Description: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
Image Unavailable-CA76333-868

Roto-Therm™ Incubating Rotating Mixer, Benchmark Scientific

Supplier: BENCHMARK SCIENTIFIC CA
Description: Roto-Therm™ series of incubated rotating mixers provide a wide range of mixing capabilities. They are suitable for carrying out an array of laboratory applications including resuspension, protein binding, nucleic acid purification, histochemistry, hybridization.

Image Unavailable-10666-194

Anti-TRPM4 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10666-194)
Supplier: Bioss
Description: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) >K(+) >Cs(+) >Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.Involvement in disease:Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B) [MIM:604559]. It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
Image Unavailable-CA76333-864

Roto-Mini™ Rotating Mixer, Benchmark Scientific

Catalog Number: (CA76333-864)
Supplier: BENCHMARK SCIENTIFIC CA
Description: Roto-Mini™ series of rotating mixers provide a wide range of mixing capabilities, suitable for an array of laboratory applications including resuspension, protein binding, nucleic acid purification and more.
Image Unavailable-CAAA43268-A1

Silver(I) oxide electrical grade

Supplier: Thermo Scientific Chemicals
Description: For battery plates, pollution control filters

Certificates

Product Image-76104-258

Bizflame Flame Resistant Crew Neck Shirt, Portwest

Supplier: Portwest
Description: Bizflame 100% flame resistant crew neck shirt.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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