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Image Unavailable-10344-032

Anti-NFATc2 Rabbit Polyclonal Antibody (Cy5.5®)

Description: Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.
Catalog Number: 10344-032
Supplier: Bioss
Image Unavailable-10372-718

Anti-Troponin I Rabbit Polyclonal Antibody (Cy7®)

Description: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Catalog Number: 10372-718
Supplier: Bioss
Image Unavailable-CAAAJ62728-MCR

Fura 2-AM

Description: A calcium indicator; derivative of Fura-2 used to load the chelator into cells
Catalog Number: CAAAJ62728-MCR
Supplier: Thermo Scientific Chemicals

Certificates


Image Unavailable-CAAAJ60481-MF

Calpeptin ≥98%

Description: Inhibitor of the calcium-dependent protease calpain and cathepsin L
Catalog Number: CAAAJ60481-MF
Supplier: Thermo Scientific Chemicals

Certificates


Image Unavailable-10339-484

Anti-BDKRB2 Rabbit Polyclonal Antibody (Cy3®)

Description: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Catalog Number: 10339-484
Supplier: Bioss
Product Image-CA45000-448

Corning® PBS (Phosphate-Buffered Saline), Corning

Description: Phosphate buffered saline (PBS) is a buffer solution containing sodium chloride, sodium phosphate, and in some formulations potassium chloride and potassium phosphate
Catalog Number: CA45000-448
Supplier: Corning

Certificates


Image Unavailable-10419-058

Anti-PRKCZ Rabbit Polyclonal Antibody

Description: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Catalog Number: 10419-058
Supplier: Bioss
Image Unavailable-10419-076

Anti-PRKCZ Rabbit Polyclonal Antibody (Cy7®)

Description: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Catalog Number: 10419-076
Supplier: Bioss
Product Image-89153-534

Anti-Ryanodine Receptor Mouse Monoclonal Antibody

Description: The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).
Catalog Number: 89153-534
Supplier: Enzo Life Sciences
Product Image-10399-802

Anti-KLRB1 Rabbit Polyclonal Antibody

Description: Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from at least four distinct genes. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA1 (ATP2B1) is a ubiquitously expressed form of the PMCA calcium exporter family.
Catalog Number: 10399-802
Supplier: Bioss
Product Image-10101-198

Anti-CATSPER2 Rabbit Polyclonal Antibody

Description: Calcium ions play a primary role in the regulation of sperm motility. Anti-CATSPER2 belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. A second, closely linked copy of this gene has been identified. Although multiple transcript variants encoding protein isoforms have been characterized, they seem to be only transcribed from this gene. Additional splice variants have been described but their full-length nature has not been determined.
Catalog Number: 10101-198
Supplier: Prosci
Image Unavailable-10372-712

Anti-Troponin I Rabbit Polyclonal Antibody (Cy3®)

Description: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Catalog Number: 10372-712
Supplier: Bioss
Image Unavailable-10390-130

Anti-ADCY9 Rabbit Polyclonal Antibody (Cy5®)

Description: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).
Catalog Number: 10390-130
Supplier: Bioss
Product Image-10390-116

Anti-ADCY9 Rabbit Polyclonal Antibody

Description: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).
Catalog Number: 10390-116
Supplier: Bioss
Image Unavailable-10339-490

Anti-BDKRB2 Rabbit Polyclonal Antibody (Cy7®)

Description: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Catalog Number: 10339-490
Supplier: Bioss
Image Unavailable-10491-068

Anti-ORAI2 Rabbit Polyclonal Antibody (Cy7®)

Description: Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.
Catalog Number: 10491-068
Supplier: Bioss
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