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Product Image-10084-422

Anti-CHAF1A Rabbit Polyclonal Antibody

Catalog Number: (10084-422)
Supplier: Proteintech
Description: Chromatin assembly factor 1 (CAF1) is the only histone chaperone known to assemble histones H3 and H4 onto newly synthesized DNA both in vitro and in vivo . The 938 amino acid multidomain p150 (CHAF1A) binds via its C-terminal third to p60, which is an essential step for nucleosome assembly because knocking down either subunit disrupts the activity . In addition, CAF1 facilitates DNA synthesis depending on the binding of the N-terminal 31 residues of p150 to the proliferating cell nuclear antigen (PCNA), which acts as a sliding clamp to stimulate the processivity of DNA polymerase . CHAF1A regulates the formation of heterochromatin in mammalian cells during replication and in plants it maintains the transcription of certain subsets of genes. Furthermore, CHAF1A exists in a chromatin-remodeling complex WINAC, which coactivates ligand-induced transactivation function of the vitamin D receptor .
Product Image-CA76407-370

BsmBI-v2

Supplier: New England Biolabs (NEB)
Description: NNNN and is optimized for Golden Gate Assembly.

Image Unavailable-10431-212

Anti-RBBP4 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10431-212)
Supplier: Bioss
Description: RbAp48 (Retinoblastoma-binding protein p48 or Rb-associated protein p48)is a WD repeat protein that is a core histone binding subunit common to several complexes involved in chromatin assembly, chromatin remodeling, and histone deacetylation. These complexes include Chromatin Assembly Factor 1 (CAF1), which is required for chromatin assembly following DNA replication and repair, the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and subsequent transcriptional repression, the nucleosome remodeling and histone deacetylation complex NuRD, the nucleosome remodeling factor (NURF) complex, and the PRC2 complex, which promotes repression of homeotic genes during development. RpAp48 also interacts with the retinoblastoma protein, and with SPEN/MINT and BRCA1. It is also a component of the DREAM complex, which represses cell cycle-dependent genes in quiescent cells.
Product Image-CA97012-746

Kalrez® Small Seal O-Ring, High Temperature, Size 009, PerkinElmer

Catalog Number: (CA97012-746)
Supplier: PerkinElmer
Description: Designed for use in the TurboMatrix Upper Seal Assembly and at high temperatures (above 225 °C).
Image Unavailable-EM1.18338.0001

Accessories for Turbiquant®

Supplier: MilliporeSigma
Description: In addition to spare cuvettes and light sources, the pour and flow cells have been developed to improve efficiency. The pour through assembly provides a single one-time cuvette alignment and simplified rinsing.

Product Image-80073-364

Accessories for Vacuum Traps, O-Ring Joints, Chemglass

Supplier: Chemglass
Description: Fits Joint Size: 50/30. Clamp is used in the assembly of CG-1198 through CG-1201 chromatography column components having spherical joints. Made entirely of stainless steel with locking screw.

Small Business Enterprise

Product Image-76533-516

Sentinel XL® CBRN Butyl Hood Assembly, ILC Dover

Catalog Number: (76533-516)
Supplier: ILC DOVER LP
Description: The only CBRN loose-fitting powered air purifying respirator (PAPR) hood designed to deliver a CAP 2 protection rating when used with the Sentinel XL® blower.
Image Unavailable-CATWTX3273

Sterile IPA 70% Spray, ITW Texwipe

Supplier: ITW Texwipe
Description: This Sterile 70% Isopropanol (IPA) spray bottle ensures added sterility by eliminating the handling and assembly usually associated with IPA Trigger sprays

SDS Certificates

Product Image-77200-610

Staticide® Conductive Trays

Supplier: ACL Staticide
Description: Staticide® conductive trays are designed to protect against ESD when used for assembling, soldering, or carrying static-sensitive components.

Image Unavailable-76078-770

Anti-Bub1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76078-770)
Supplier: Bioss
Description: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Product Image-32932-230

Cleanteam® 40 Denier Tricot Gloves, Protective Industrial Products

Supplier: PIP
Description: Cleanteam® 40 denier tricot inspection glove with rolled hem cuff ideal for inspection and electronics assembly.

Image Unavailable-10487-446

Anti-CHAF1A Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10487-446)
Supplier: Bioss
Description: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). The CCR4-NOT complex functions as general transcription regulation complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
Image Unavailable-10487-450

Anti-CHAF1A Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10487-450)
Supplier: Bioss
Description: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). The CCR4-NOT complex functions as general transcription regulation complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
Product Image-89001-652

Accessories

Supplier: DWK Life Sciences (KIMBLE)
Description: Bore of Plug (mm); 2.8 Replacement for 17021H, 17800, 17810 and 29050H. Liquid contact of stopcock surfaces are PTFE. For easier assembly, tip should be wetted before installation.

Certificates

Image Unavailable-76078-772

Anti-Bub1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76078-772)
Supplier: Bioss
Description: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.
Product Image-77392-722

Nanodisc MSP1D1 DMPC

Catalog Number: (77392-722)
Supplier: CUBE BIOTECH
Description: This product is a pre-assembled nanodisc. Its intended purpose is to stabilize a cell-free expressed membrane protein.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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