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Supplier: Thermo Scientific Chemicals
Description: 5,5-Dimethylacetylacetone 99%
Supplier: Thermo Scientific Chemicals
Description: 5,5-Diphenylhydantoin 99%
Supplier: CUBE BIOTECH
Description: AASTYs (Acrylic acid-co-styrenes) - like AASTY 6-55 - are highly-alternating copolymers, well-suited for generating native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 6-55 gets its name from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general, lighter AASTYs, like 6-55 tend to be more aggressive, while heavier AASTYs, such as 11-45 show higher thermodynamic stability.

The exact composition of AASTY copolymers shows different extraction efficiency, depending on the lipid composition of the lipid bilayers being formulated into nanodiscs. As AASTY is made by controlled radical polymerization techniques, the dispersity of polymer molecular weight distribution is low, and the molecular weights are controlled. This means that excess AASTY copolymer can be removed by dialysis after nanodisc formation. Based on previous findings on SMA, it is the expectation that AASTY of different molecular weights will display different rates of nanodisc formation, extraction efficacy, and stability of resulting nanodiscs.

Every membrane protein solubilization needs to undergo a screening process before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process, we offer a handy Screening Kit for AASTYs to test them all. Additionally, we recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

Supplier: Thermo Scientific Chemicals
Description: Fieser: 7,126
Supplier: TCI America
Description: 3-Bromodibenzothiophene 5,5-Dioxide, Purity: >98.0%(GC), CAS Number: 116668-69-0, Molecular Formula: C12H7BrO2S, Molecular Weight: 295.15, Synonyms: 3-Bromodibenzosulfolane, 3-Bromodibenzothiophene Sulfone, Size: 200MG

Supplier: TCI America
Description: 2-Bromodibenzothiophene 5,5-Dioxide, Purity: >95.0%(GC), CAS Number: 53846-85-8, Molecular Formula: C12H7BrO2S, Molecular Weight: 295.15, Synonyms: 2-Bromodibenzosulfolane, 2-Bromodibenzothiophene Sulfone, Size: 1G

Supplier: Thermo Scientific Chemicals
Description: 2,2',5,5'-Tetramethylbiphenyl 98%
Catalog Number: (CA80057-612)
Supplier: MilliporeSigma
Description: 3,3',5,5'-Tetramethylbenzidine (TMB) soluble

Supplier: Thermo Scientific Chemicals
Description: 3,3',5,5'-Tetramethylbiphenyl ≥97%
Supplier: CUBE BIOTECH
Description: AASTYs (Acrylic acid-co-styrenes) - like AASTY 11-55 - are highly alternating copolymers, well-suited for generating native lipid nanodiscs. They are a 2022 novel developed series for membrane protein solubilization & stabilization. AASTY 11-55 is named from its molecular weight and Acrylic Acid : Styrene Ratio. These varying ratios of acrylic acid to styrene contribute to the hydrophilic properties of our AASTYs. In general lighter AASTYs, like 6-45 tend to be more aggressive, while heavier AASTYs, such as 11-55 show higher thermodynamic stability.

The exact composition of AASTY copolymers shows different extraction efficiencies, depending on the lipid composition of the lipid bilayers being formulated into nanodiscs. As AASTY is made by controlled radical polymerization techniques, the dispersity of polymer molecular weight distribution is low, and the molecular weights are controlled. This means that excess AASTY copolymer can be removed by dialysis after nanodisc formation. Based on previous findings on SMA, it is the expectation that AASTY of different molecular weights will display different rates of nanodisc formation, extraction efficacy, and stability of resulting nanodiscs.

Every membrane protein solubilization needs to undergo a screening process before. The characteristic phospholipid environment surrounding the different membrane proteins in question performs differently well with each polymer. To support you in this process we offer a handy Screening Kit for AASTYs to test them all. Additionally, we recommend the two following publications if you would like to get further information: Smith et al. 2020 & Timcenko et al. 2022

Supplier: TCI America
Description: CAS Number: 25570-02-9
MDL Number: MFCD00051910
Molecular Formula: C16H18
Molecular Weight: 210.32
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Color: White
Melting point (°C): 50

SDS

Supplier: TCI America
Description: CAS Number: 1016-05-3
MDL Number: MFCD00004970
Molecular Formula: C12H8O2S
Molecular Weight: 216.25
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Melting point (°C): 236

SDS

Catalog Number: (TCD4842-100MG)
Supplier: TCI America
Description: 5,5'''-Dihexyl-2,2':5',2'':5'',2'''-quaterthiophene, Purity: >98.0%(GC), CAS Number: 132814-92-7, MF: C28H34S4, MW: 498.82, Synonym: A, omega-Dihexylquaterthiophene, Form: Crystal-Powder, Solid, Color: Yellow - Yellow red, Size: 100MG

SDS


Supplier: TCI America
Description: 2,2'-Bithiophene-5,5'-dicarboxaldehyde, Purity: >98.0%(GC), CAS number: 32364-72-0, Molecular Formula: C10H6O2S2, Molecular Weight: 222.28, Synonyms: 5,5'-Diformyl-2,2'-bithiophene, Form: Crystal- Powder, Pale yellow - Deep reddish yellow, Size: 5G

Supplier: TCI America
Description: CAS Number: 77-71-4
MDL Number: MFCD00005266
Molecular Formula: C5H8N2O2
Molecular Weight: 128.13
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Melting point (°C): 175
Flash Point (°C): 193
Supplier: TCI America
Description: 2,8-Dibromodibenzothiophene 5,5-Dioxide, Purity: >95.0%(GC), CAS: 40307-15-1, MF: C12H6Br2O2S, MW: 374.05, Synonyms: 2,8-Dibromodibenzosulfolane, 2,8-Dibromodibenzothiophene Sulfone, Form: Crystal - Powder, White - Very pale reddish yellow, Size: 1G

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