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Image Unavailable-10435-212

Anti-SMPD1 Rabbit Polyclonal Antibody

Catalog Number: (10435-212)
Supplier: Bioss
Description: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.
Image Unavailable-89517-546

Anti-RAB39B Rabbit Polyclonal Antibody

Catalog Number: (89517-546)
Supplier: Abgent
Description: Western Blot: 1:1000
Image Unavailable-10448-604

Anti-ALOX15 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10448-604)
Supplier: Bioss
Description: Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
Product Image-10090-470

Anti-MRPS22 Rabbit Polyclonal Antibody

Catalog Number: (10090-470)
Supplier: Proteintech
Description: MRPS22, also named as C3orf5, RPMS22 and S22mt, is a component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Defects in MRPS22 are the cause of combined oxidative phosphorylation deficiency type 5 (COXPD5). MRPS22 is a 360-amino-acid protein that has been found in a limited number of species, having no ortholog in fungi or prokaryotes. The exact location of MRPS22 in the three dimensional structure of the ribosome and its exact function are currently unknown. Recently, a MRPS22 defect was shown to strongly hamper assembly of the small ribosomal subunit, whereas assembly of the large subunit and part of the small subunit were only mildly affected.
Product Image-CAAA41859-AK

N,N-Dimethylformamide, anhydrous ≥99.7%, chemSeal™ for HPLC

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00003284 Beilstein Registry No.: 605365 Notes: Same HPLC specifications as 22915 Fieser: 1,273 9,182 11,198 12,203 14,148 16,144 18,146 19,137 21,178

Certificates

Image Unavailable-CAAA41379-18

Xylenol orange tetrasodium salt ACS

Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00044293

Certificates

Image Unavailable-76120-678

Anti-ANKLE2 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76120-678)
Supplier: Bioss
Description: Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKLE2 (ankyrin repeat and LEM domain containing 2), also known as LEMD7, is a 938 amino acid single-pass membrane protein containing an ANK repeat and a LEM domain. Existing as two isoforms produced by alternative splicing events, the gene encoding ANKLE2 maps to human chromosome 12, which encodes over 1100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.
Product Image-47748-186

SP Bel-Art Evaporating Dish, Bel-Art Products, a part of SP

Catalog Number: (47748-186)
Supplier: Bel-Art Products, a Part of SP
Description: Smooth polypropylene dish with easy pour spout holds up to 175 mL.
Product Image-89158-064

Sodium 4-phenylbutyrate ≥98% (by UHPLC)

Catalog Number: (89158-064)
Supplier: Enzo Life Sciences
Description: Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.
Image Unavailable-TCP0300-500G

Diisononyl phthalate (mixture of branched chain isomers)

Catalog Number: (TCP0300-500G)
Supplier: TCI America
Description: CAS Number: 68515-48-0
Molecular Formula: C26H42O4
Molecular Weight: 418.62
Form: Clear Liquid
Color: Colorless
Boiling point (°C): 252
Melting point (°C): -43
Flash Point (°C): 235
Specific Gravity (20/20): 0.98

SDS Certificates


Image Unavailable-10485-204

Anti-FbxL12 Rabbit Polyclonal Antibody

Catalog Number: (10485-204)
Supplier: Bioss
Description: F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune responses, signaling cascades and developmental events) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I˚B-å and ∫-catenin, for proteasomal degradation. FBL12 (F-box and leucine-rich repeat protein 12), also designated FBXL12, is a 326 amino acid protein that contains one F-box domain, five LRR (leucine-rich) repeats and exists as two alternatively spliced isoforms. FBL12 interacts with both Skp1 and CUL-1, and is encoded by a gene that maps to human chromosome 19p13.2.
Image Unavailable-10448-608

Anti-ALOX15 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10448-608)
Supplier: Bioss
Description: Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
Product Image-14219-930

UVP Hybridization Ovens, Analytik Jena

Supplier: Analytik Jena US
Description: UVP Hybridization Ovens, are self-contained units used for hybridization applications, ultraviolet crosslinking, or both procedures in one system. The hybridizing oven portion is ideal for Southern, Northern, and Western blots; in situ hybridization; and binding nucleic acids to nitrocellulose or nylon-reinforced transfer membranes or other media.

Small Business Enterprise Product available on GSA Advantage®

Image Unavailable-10665-744

Anti-ISLR2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10665-744)
Supplier: Bioss
Description: The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. ISLR2 (immunoglobulin superfamily containing leucine-rich repeat 2), also known as LINX (leucine-rich repeat domain and immunoglobulin domain-containing axon extension protein), is a 745 amino acid single-pass membrane protein that contains five LRR repeats, one Ig-like (immunoglobulin-like) domain, a LRRCT domain and one LRRNT domain. ISLR2 exists as a homomultimer and is essential for axon extension during neural development. The gene encoding ISLR2 maps to human chromosome 15q24.1.
Image Unavailable-CA82022-782

DSP (Dithiobis(succinimidyl propionate))

Catalog Number: (CA82022-782)
Supplier: G-Biosciences
Description: Dithiobis(succinimidyl propionate) Homobifunctional Cross Linker.
Product Image-10448-536

Anti-ALOX15 Rabbit Polyclonal Antibody

Catalog Number: (10448-536)
Supplier: Bioss
Description: Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
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